Agilent triple quadrupole 6495C mass spectrometer with iFunnel ion optics and ESI source with Jet Stream technology: scan range from 5 to 2,250 m/z, scan rate = 15,000 Da/s, maximum scan rate = 500 MRM/s, MRM transitions = 450 per time segment, > 40,000 ion transition per method. Signal-to-noise for 1 pg reserpine (609 to 195 m/z) = 150,000:1. It can be coupled with capillary electrophoresis (CE 7100) or UHPLC (1290 Infinity II) using MassHunter software.