The INPROF (INterrelation of PROtein Features) web server provides an useful tool to retrieve several metrics and information about the relationship (similarities) among a list of proteins. The web server retrieves interrelation data about a wide number of heterogeneous properties (called Categories) like sequences, domains, secondary/tertiary structures or ontological terms. Also, metrics can be obtained taking into account these categories in the alignment of the protein sequences. Up to 54 different metrics can be calculated from this web server to interrelate sets of proteins (See Help page for details).
1. Enter a list of proteins in the text area. This list can be provided by the UniProtKB entry name or accession number in different rows, for example:
or in FASTA format including protein sequences (See example). A file with this information can also be uploaded.
2. Configure the alignment tool and feature categories you would like to use to interrelate your proteins (See "More options..."):
3. Click Submit to send your query.
4. A table with values for the metrics associated to the selected categories of your proteins is provided. This table can also be downloaded in a tab-separated file.
5. A detailed description of each metric is provided in the following link Feature Description.
6. The INPROF web server can be called from programming languages like Python, Perl or R. See a Python example script here.
7. For any additional information, questions or reporting bugs, please contact email@example.com.