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Síntesis de
Productos Naturales Bioactivos:
A.F. Barrero; J.
Altarejos; E.J. Alvarez-Manzaneda; J.M. Ramos; S. Salido.
Synthesis of "Ambrox"
from communic acids.
Tetrahedron 49,
6251(1993)
A.F. Barrero;J.
Altarejos; E.J. Alvarez-Manzaneda; J.M. Ramos; S. Salido.
Amber-type odorants
fom communic acids.
Tetrahedron 49,
9525 (1993)
A.F. Barrero. E.J.
Alvarez-Manzaneda; J. Altarejos; S. Salido; J.M. Ramos
Synthesis of Ambrox
from sclareol and (+)-cis-abienol.
Tetrahedron 49,
10405 (1993)
A.F. Barrero; E.
A-Manzaneda; J. Altarejos; S. Salido; J.M. Ramos; M.S.J.
Simmonds and W.M. Blaney.
Synthesis of
Biologically Active Drimanes and Homodrimanes from (-)-Sclareol.
Tetrahedron 51,
7435 (1995)
A.F. Barrero ;
J.F. Sánchez and J. Elmerabet.
An Efficient
Synthesis of the Antifungal Dilactone LL-Z1271a
and of other Biologically Active Compounds.
Tetrahedron Letters
36, 5251(1995)
A. F. Barrero; E.
Oltra; and M. Alvarez.
Palladium II
Promoted Rearrangement of Germacranolides.Synthesis of(+)-Stoebenolide
and (+)-Dehydromelitensin
Tetrahedron
Letters 39, 1401(1998)
Alejandro F.
Barrero; J. Enrique Oltra;Armando BarrAgán and Miriam Alvarez.
Approaches to the
Synthesis of 8 epi-Vernolepin from Germacranolides.
Journal Chemical
Society-Perkin I 4107 (1998)
A.F. Barrero; J.F.
Sánchez; J. Elmerabet; D. Jimenez; F.A.Macias and A.M. Simonet.
Enantiospecifie
Syntheses of the potent Bioactives Nagilactone F and the Mould
Metabolithe LL-1271a.A
Study of Alhelophatic Potencial.
Tetrahedron 55,
7289 (1999)
Alejandro F.
Barrero; J. Enrique Oltra and Miriam Álvarez
A new strategy for
the synthesis (+)-vernolepin related compounds:an unusual sulfene
elimination leads to the 2-oxa-cis-decalin skeleton
Tetrahedron
Letters 41, 1959 (2000).
A.F. Barrero; E.
Alvarez-Manzaneda; R.Chahboun; J. M. Cuerva; A. Segovia.
Synthetic
Applications of the Thermal Rearangements of Ozonides: First
Enantiospecific Synthesis of Marine Metabolite Luffarin W
Synlett 9, 1269
(2000)
A.F. Barrero;
Alvarez-Manzaneda E; Alvarez-M. R; R.Chahboun; Meneses R;J. M. Cuerva;
Aparicio M Romera J.L.
Approach to the
Synthesis of Antitumor Quassinoids from Labdane Diterpenes: An Efficient
Synthesis of a Picrasane Related Intermediate.
Org. Letters
3,
647 (2001)
A.F. Barrero, S.
Arseniyadis, J.F. Quilez, M.M. Herrador, M. Valdivia and D. Jimenez.
The First Synthesis
of the Antifungal Oidiolactones C from trans-Communic Acid. Citotoxyc
and Antimicrobial Activity in Podolactone-related Compounds.
J.Org. Chem. 67,
2501 (2002)
A. F. Barrero; J.
E. Oltra; M. Álvarez; A. Rosales.
First Synthesis of
(+)-8-Deoxyvernolepin and Its 11,13-Dihydroderivative. A Novel Reaction
Initiated by the Sulfene Elimination leads to the 2-Oxa-cis-decalin
Skeleton.
J. Org. Chem.
67,
5461(2002)
A. F. Barrero; E.
J. Alvarez-Manzaneda Roldán; J. L. Romera Santiago; R. Chahboun
Highly
Diastereoselective Synthesiss of Manoyl Oxide Derivatives by TiCl4-Catalyzed
Nucleophilic Cleavage of Ambracetal Derivatives.
Synlett 15, 2313
(2003)
E. J. Alvarez-Manzaneda,
J. L. Romera, A. F. Barrero, R. Alvarez-M., R. Chahboun, R. Meneses, M.
Aparicio.
Synthetic approach
to pentacyclic quassinoids from communic acids, via ambracetal
derivatives
Tetrahedron 61, 837
(2005)
J. I. Candela Lena, E. M. Sánchez Fernández, A. Ramani, N. Birlirakis,
A. F. Barrero, S. Arseniyadis
Mild protocols for
generating molecular complexity: a comparative study of hetero-domino
reactions based on the oxidant and the substitution pattern
Eur. J. Org. Chem.
en prensa
(2005)
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Síntesis de Meroterpenoides:
A. F. Barrero;
Enrique J. Alvarez-Manzaneda and Rachid Chahboun.
Enantiospecific Synthesis of
(+)-Puupehenone from (-)-Sclareol and Protocatechualdehyde.
Tetrahedron Letters1997,
38,2325
A. F. Barrero; Enrique J.
Alvarez-Manzaneda and Rachid Chahboun.
Enantiospecific Synthesis of
Wiedendiol-B from (-)-Sclareol and (+)-cis-Abienol
Tetrahedron Letters
1997,38,8101-8104
A. F. Barrero; Enrique J.
Alvarez-Manzaneda and Rachid Chahboun.
Synthesis of Wiedendiol-A and
Wiedendiol-B from Labdane Diterpenes
Tetrahedron
1998,54,5635-5650
A. F. Barrero;
Enrique J. Alvarez-Manzaneda; M. Mar Herrador; Mónica V. Valdivia and
Rachid Chahboun.
Synthesis of Monoterpenic
Analogues of Puupehenone and Puupehedione.
Tetrahedron Letters
1998,39,2425-2428
A.F. Barrero; E.
Alvarez-Manzaneda; M.M. Herrador.; R.Chahboun and P.Galera.
Synthesis and Antitumoral
Activities of Marine ent-chromazonarol and Related Compounds.
Bioorganic and Medicinal
Chemistry Letters 1999,9,2325-2329
A.F. Barrero; E. Alvarez-Manzaneda;
R.Chahboun; M.Cortés;V.Armstrong.
Synthesis and Antitumoral
Activity of Puupehedione and Related Compounds.
Tetrahedron
1999,55,15181-
V. Armstrong; A. F.
Barrero; E. J. Alvarez-Manzaneda; M. Cortés; B. Sepúlveda
An Efficient Stereoselective
Synthesis of Cytotoxic 8-epipuupehedione
J. Nat. Prod.
2003,66,1382-1382
M. E. Castro; M.
González-Iriarte; A. F. Barrero; N. Salvador-Tormo; R. Muñoz-Chápuli; M.
A. Medina; A. R. Quesada
Study of puupehenone and related
compounds as inhibitors of angiogenesis
Int. J. Cancer
2004,110,31-35
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Métodos de Síntesis Orgánica:
A.F.
Barrero; E. Alvarez-Manzaneda; R. Chahboun; R. Meneses and M. Aparicio.
Unusual
Baeyer-Villiger Rearrangement of Terpenic Aldehydes. Application to the
Synthesis of Natural nor-Terpenes.
SynLett
713 (1999)
A.F.
Barrero; E. Alvarez-Manzaneda; R. Alvarez-Manzaneda; R.Chahboun;
R.Meneses, M. Aparicio
Ring A
Functionalization of Terpenoids by the Unusual Baeyer Villiger
Rearrangement of Aliphatic Aldehydes
Synlett 6, 713 (1999)
A.F.
Barrero; E. Alvarez-Manzaneda; R.Chahboun.
Convenient
Preparation of Carbonyl Compounds from 1,2-Diols Utilizing the Mitsunobu
Conditions.
Tetrahedron Letters 41, 1959 (2000)
A.F.
Barrero; E. Alvarez-Manzaneda; R.Chahboun; R.Meneses.
Raney Nickel: An
Efficient Reagent to Achieve the Chemoselective Hydrogenation of
a,b-
Unsaturated Carbonyl Compounds.
Synlett 1663 (2000)
A.F.
Barrero; E.J. Alvarez-Manzaneda; R. Chahboun, R. Meneses.
Chemoselective
Reduction of Aldehydes in presence of Ketones Utilizing Raney Kickel.
Synlett 197 (2000)
A.F.
Barrero, E. Alvarez-Manzaneda R;R.Chahboun
Raney Nickel: An
effective Reagent for Reductive Dehalogenation of Organic Halides.
Synlett 485 (2001)
Alejandro F. Barrero; Juan M. Cuerva; M.Mar Herrador and Mónica Valdivia
A New Strategy for
the Synthesis of Cyclic Terpenoids Based on the Radical Opening of
Aciclyc Epoxipolyenes.
J. Org.
Chem 66, 4074 (2001)
A. F.
Barrero; A. Rosales, J.
M. Cuerva; A. Gansäuer; J. E. Oltra
Titanocene-catalysed,
selective reduction of ketones in aqueous media. A safe, mild,
inexpensive procedure for the synthesis of secondary alcohols via
radical chemistry
Tetrahedron Lett. 44, 1079 (2003)
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Ciclaciones biomiméticas:
A.F. Barrero; J.F.
Sanchez; J. Altarejos.
Biomimetic cyclization of
communic acids to pimarane skeleton.
Tetrahedron Letters
29,3713-3717(1988)
A.F. Barrero; R.
Quintana; J. Altarejos
Biomimetic synthesis of
12-oxy-pimaranes from 12,13-epoxy-labdadienes.
Tetrahedron 47,
4441-4455 (1991)
A.F. Barrero; J.F. Sanchez; A.
Barrón; A. Ramirez.
Biomimetic cyclizations of a
germacranolide from Tanacetum annuum
Phytochemistry
31,
332-335 (1992)
A.F. Barrero, E.
Alvarez-Manzaneda, P. Linares.
Synthesis of Karahana Ether and
Karahanaenone by Selective Cyclization of 6,7-Epoxygeranyl Acetate.
Tetrahedron Letters
50,13239-13253( 1994)
A.F. Barrero; J.
Altarejos; E. A-Manzaneda; J.M. Ramos and S. Salido.
Synthesis of (+)-Ambrox from
(E)-Nerodiol and b- Ionone via Allylic Alcohol[2,3] Sigmatropic
Rearrangement.
J. Org. Chem
61,2215-2219
(1996)
A.F. Barrero, J.
Enrique Oltra, Víctor Morales and Míriam Álvarez.
Biomimetic cyclization of cnicin
to malacitanolide, a cytotoxic eudesmanolide from Centaurea malacitana
Journal of Natural Products
60,1034- 1035 (1997)
A.F. Barrero;
E. Alvarez-Manzaneda; M.M. Herrador.; R. Alvarez-Manzaneda; J.
Quilez;R.Chahboun; P. Linares and A. Rivas.
The First Route toward
Oxygenated Monocarbocyclic Terpenoids: Synthesis of Elegansidiol, a New
Sesquiterpene from Santolina elegans.
Tetrahedron Letters
40,8273-8277 (1999)
A.F. Barrero; E.
Alvarez-Manzaneda; R.Chahboun; A, Rodríguez Rivas and P, Linares
Synthesis of Natural Oxygenated
Monocarbocyclic Sesquiterpenoids from 6,7-Epoxygeranyl Acetate
Tetrahedron
56,6099-6112 ( 2000)
Alejandro F. Barrero;
Juan M. Cuerva; M.Mar Herrador and Mónica Valdivia
A New Strategy for the Synthesis
of Cyclic Terpenoids Based on the Radical Opening of Aciclyc
Epoxipolyenes.
J. Org. Chem 66,
4074-4078 ( 2001)
A.F.Barrero;
J.M.Cuerva; E. Oltra; E. Alvarez Manzaneda.
Stereoselective Synthesis of
Achilleol A Using Titanium (III) Chemistry.
Tetrahedron Letters
43,2793-2796 (2002)
A.F. Barrero, J.E.
Oltra, J.M. Cuerva and A. Rosales.
Effects of Solvents and Water in
Ti(III)-Mediated Radical Cyclizations of Epoxygermacrolides.
Straightforward Synthesis and Absolute Stereochemistry of
(+)-3-Hydroxyreynosin and Related Eudesmanolides.
J. Org. Chem.
67,2566-2571 (2002)
A. F. Barrero; M. M. Herrador;
J. F. Quílez del Moral; M. Valdivia.
A Convenient Synthesis of
A-Ring-Functionalized Podolactones. Revision of the Structure of
Wentilactone B.
Organic Letters.
4, 1379-1382 ( 2002)
A.F. Barrero, J.E.
Oltra, J.M. Cuerva and A. Rosales.
Effects of Solvents and Water in
Ti(III)-Mediated Radical Cyclizations of Epoxygermacrolides.
Straightforward Synthesis and Absolute Stereochemistry of
(+)-3-Hydroxyreynosin and Related Eudesmanolides.
J. Org. Chem.
67, 2566-2571 (2002)
A. F. Barrero; A. Rosales, J. M.
Cuerva; J. E. Oltra
Unified
Synthesis of Eudesmanolides, Combining Biomimetic Strategies with
Homogeneous Catalysis and Free-Radical Chemistry
Organic
Lett. 11, 1935-1938 ( 2003)
J. Justicia, A.
Rosales, E. Buñuel, J. L. Oller-Lopez, M. Valdivia,
A. Haidour, J.
E. Oltra, A. F.
Barrero, D. Cardenas, J. M. Cuerva.
Titanocene-catalyzed
cascade cyclization of epoxypolyprenes: straightforward synthesis of
terpenoids by free-radical chemistry
Chemistry A European Journal 10,1778-1788
(2004)
A. F. Barrero, S. Arseniyadis,
M. M. Herrador, J. F. Quílez del Moral, J. F. Arteaga, E. M. Sánchez
Sulfanyl Radicals-Induced Cyclization of Lynalyl Acetate to the Iridane
Skeleton: A Short Synthesis of (±)-Dehydroiridomyrmecin
Synlett 591-594 (2005)
A. F. Barrero, S. Arseniyadis,
J. F. Quílez del Moral, M. M. Herrador, A. Rosellón
Enantioselective annulation
using Nazarov reagent: Synthesis of (+)-preoleanatetraene
Synlett 789-792 (2005)
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Obtención de Productos Naturales de Plantas:
A.F.
Barrero; J.F. Sanchez; F. Cuenca.
Dramatic variation
in diterpenoids of different populations of Bellardia trixago.
Phytochemistry 27, 3676 (1988).
A.F.
Barrero; J.F. Sanchez; N. Ferrol; A. San Feliciano.
Conformational
isomers of 14-hydroxy-9-epi-ß-caryophyllene isolated from Juniperus
oxycedrus.
Tetrahedron Letters
30, 247 (1989).
A.F.
Barrero; E.J. Alvarez-Manzaneda; R. Alvarez-Manzaneda.
Achilleol A. A new monocyclic triterpene skeleton
from Achillea odorata.
Tetrahedron Letters 30, 3351 (1989).
A. San Feliciano; M. Medarde;
J.M. Miguel del Corral; A. Aramburu; A.F. Barrero.
Aquatolide. A new
type of humulane-related sesquiterpene lactone.
Tetrahedron Letters
30,
2851(1989).
A.F.Barrero; J.E. Oltra; A. Barragán
Evidences about the
stereochemistry of 14-hidroxy-9-epi-ß-caryophillene.
Tetrahedron Letters
31, 4069
(1990).
A.F.
Barrero; E.A. Manzaneda; R.A. Manzaneda; S. Arseniyadis; E. Guillet.
Achilleol B: a new
tricyclic triterpene skeleton from Achillea odorata.
Tetrahedron 46, 8161(1990).
A.F.
Barrero; M.M. Herrador; P. Arteaga.
Sesquiterpenes and
phenylpropanoids from Seseli vayredanum .
Phytochemistry
31,
203
(1992).
A.F. Barrero; A.
Haidour and M. Muñoz.
Sesquipinsapols A
and B: Two sesquilignans from Abies pinsapo .
Natural Products
Letters 2, 255 (1993).
A.F.Barrero; J.Molina; J.E. Oltra; J.Altarejos; A. Barragán; A. Lara and
M. Segura.
Stereochemistry of
14-Hydroxy-b-
caryophyllene and Related Compounds.
Tetrahedron 51, 3813 (1995).
A.F.Barrero; M.M. Herrador; A. Haìdour; J. Altarejos; P. Arteaga and R.
Chahboun.
(3S,6R)-3,6-Dihydroxy-10-methylundecanoic Acid and a Trimeric
Diester Derivate from Lafuentea rotundifolia.
Tetrahedron Letters
36, 2649 (1995).
A.F.
Barrero; E. A-Manzaneda and A. Lara
Junicedranol, a
Sesquiterpene with a Novel Carbon Skeleton from Juniperus oxycedrus
ssp. macrocarpa.
Tetrahedron Letters
36, 6347 (1995).
A.F.
Barrero; A. Haidoür; M. Muñoz and J.M. Cuerva
Two Sesquilignans
from the Wood of Abies marocana
Phytochemistry
41, 605 (1996).
A.F.
Barrero; E. A-Manzaneda and A. Lara
Novel Tricyclic
Sesquiterpenes from Juniperus Thurifera L. Chemical conformatión of the
Druprezianane Skeleton.
Tetrahedron Letters 37, 3757 (1996).
A.F.
Barrero; M.M. Herrador, P. Arteaga; I. Rodriguez; M. Garcia.
Resorcinol
Derivatives and flavonoids of Ononix natrix subs. ramosisima.
Journal of Natural
Products 60, 65 (1997).
A.F.
Barrero;M.M.Herrador; J.F.Quilez; R. Alvarez Manzaneda; D. Portal;
J.A.Gavin; D.G.Gravalos; M.S.J. Simmonds and W.M.Blaney.
Bioactive Sesquiterpenes from Santolina Rosmarinifolia subsp.
Canescens
a Conformacional Analysis of the Germacrane Ring.
Phytochemistry
51,
529 (1999).
A.F.
Barrero; J. Quílez del Moral and A. Lara.
Sesquiterpenes from
Juniperus thurifera L. Stereochemistry in Unusual Cedrane and
Duprezianane Series
Tetrahedron 56, 3717 (2000).
A. F.
Barrero; J. F. Quílez del Moral; R: Lucas; M. Payá; M. Akssira; S. Akaad;
F. Mellouki
Diterpenoids from
Tetraclinis articualta that Inhibit Various Human Leukocyte
Functions.
J. Nat.
Prod. 66, 844 (2003).
A. F.
Barrero, J. F. Quílez del Moral, M. M. Herrador, M. Akssira,
A. Bennamara, S. Akaad,
M.
Aitigri
Oxygenated
diterpenes and other constituents from Moroccan Juniperus phoenicea and
Juniperus thurifera var. africana
Phytocemistry
65, 2507 (2004).
A. F.
Barrero, J. F. Quílez del Moral, M. M. Herrador, J. F. Arteaga, M.
Akssira, A. Benharref, M. Dakir
Abietane diterpenes
from the cones of Cedrus atlantica
Phytocemistry
66,
105 (2005).
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Biotecnología de Hongos:
A.F.
Barrero; J.F. Sanchez; E. Oltra; N. Tamayo; E. Cerdá; R. Candau; J.
Avalos.
Fusarin C and
8Z-fusarin C from Gibberella fujikuroi.
Phytochemistry
30,
2259
(1991)
A.F.
Barrero; E. Oltra; E. Cabrera; M.M. Herrador; F. Rojas; F. Reyes; F.
Godoy.
Gibelactol, a
diterpenoid from Gibberella fujikuroi.
Natural Products
Letters 1, 155 (1992)
A.F.
Barrero; E. Oltra; E. Cabrera; M.M. Herrador; J.F. Sanchez; F. Rojas; F.
Reyes.
Gibepyrones:
a-
pyrones from Gibberella fujikuroi.
Tetrahedron 49,
141
(1993)
R.
Fernández-Martín, F. Reyes, C.E. Domenech, E. Cabrera, P.M. Bramley, A.F.
Barrero, J. Avalos, E. Cerdá-Olmedo.
Gibberellin
Biosynthesis in gib mutants of Gibberella fujikuroi.
Journal of
Biological Chemistry 270, 14970 (1995)
A.F.
Barrero; E. Oltra and J.A. Poyatos
The Acidic
Metabolites from Phycomyces blakesleeanus
Phytochemistry 42, 1427 (1996)
Ramos,
J.L.; Duque,E.;Haìduor,A.; Reyes,F and Barrero,A.F.
Tolerance to
Organic Solvents in bacteria.
Journal of
Biological Chemistry 272, 3887 (1997)
David
Weinkove; Juan Angel Poyatos; Heribert Greiner; Enrique Oltra; Javier
Avalos; Leonid Fukshanky; Alejandro F. Barrero and Enrique Cerda Olmedo.
Mutants of
Phycomyces with decreased gallic acid content.
Fungal Genetics and
Biology 25, 196 (1998)
Alejandro F. Barrero; J. Enrique Oltra; Eduardo Cabrera; Fernando Reyes
and M. Álvarez
Metabolism of Gibberellins and ent-Kaurenoids in Mutants of Gibberella
fujiküroi.
Phytochemistry 50, 1113 (1999)
Alejandro F. Barrero; J. Enrique Oltra; Juan A. Poyatos, David Jimenez
and Eulalia Oliver.
Phycomisterols and
other sterols from the fungus Phycomyces blakesleeanus.
Journal of Natural
Products 61, 1491 (1999)
Alejandro F. Barrero; J. Enrique Oltra; Enrique Cerdá-Olmedo; Javier
Ávalos and José Justicia.
Microbial
Transformation of ent-Kaurenoic Acid and Its 15-Hydroxy
Derivatives by the SG138 Mutant of Gibberella fujikuroi.
J. Nat.
Prod 64, 222 (2001)
Alejandro F. Barrero; J. Enrique Oltra ; John Robinsons; Patricia Burke;
David Jimenez and Eulalia Oliver.
Sterol biosynthesis
in erg mutants of Phycomyces: Metabolic pathways and physiological
effects.
Steroids 67, 403 (2002)
J. L.
Oller-López; J. Avalos; A. F. Barrero;
J. E. Oltra
Improved GA1
production by Fusarium fujikuroi
Appl.
Microbiol. Biotechnol. 63, 282 (2003)
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