University of Granada research group in Neutron Capture Therapy of cancer

Main publications of the group (last 10 years)

 

  • P Torres-Sánchez, I Porras, N Ramos-Chernenko, F Arias de Saavedra, J. Praena, Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy. Scientific Reports 11 (1), 1-12 (2021).
  • P Torres-Sánchez, I Porras, FA de Saavedra, J Praena. Study of the upper energy limit of useful epithermal neutrons for Boron Neutron Capture Therapy in different tissues. Radiation Physics and Chemistry 185, 109490 (2021)
  • S Bortolussi, YH Liu, I Porras.  Boron Neutron Capture Therapy: From Nuclear Physics to Biomedicine. Biology 10 (5), 370 (2021)
  • I Porras, J Praena, FA de Saavedra, M Pedrosa-Rivera, P Torres-Sánchez et. al. BNCT research activities at the Granada group and the project NeMeSis: Neutrons for medicine and sciences, towards an accelerator-based facility for new BNCT therapies, medical isotope production and other scientific neutron applications. Applied Radiation and Isotopes 165, 109247 (2020)
  • C Guerrero, J Lerendegui-Marco, M Paul, M Tessler, S Heinitz et al. Neutron Capture on the -Process Branching Point of 171Tm via Time-of-Flight and Activation. Physical Review Letters 125 (14), 142701 (2020).
  • M Pedrosa-Rivera, J Praena, I Porras, MP Sabariego, U Köster et al. Thermal Neutron Relative Biological Effectiveness Factors for Boron Neutron Capture Therapy from In Vitro Irradiations. Cells 9 (10), 2144 (2020)
  • M Pedrosa-Rivera, MJ Ruiz-Magaña, I Porras, J Praena et al.  Neutron radiobiology studies with a pure cold neutron beam. Nuclear Instruments and Methods in Physics Research Section B: 462: 24-31 (2020)
  • I Lopez-Casas, J Praena, FA de Saavedra, M Sabate-Gilarte, I Porras. Exploring neutron capture therapy with 33S and 10B. Applied Radiation and Isotopes 163, 109220 (2020)
  • M Pedrosa-Rivera, MJ Ruiz-Magaña, P Alvarez, I Porras, J Praena et al. Radiobiology data of melanoma cells after low-energy neutron irradiation and boron compound administration. Applied Radiation and Isotopes 163, 109205 (2020).
  • M Pedrosa-Rivera, J Praena, I Porras, MJ Ruiz-Magaña, C Ruiz-Ruiz. A simple approximation for the evaluation of the photon iso-effective dose in Boron Neutron Capture Therapy based on dose-independent weighting factors. Applied Radiation and Isotopes 157, 109018 (2020).
  • P Mastinu, D Bisello, RA Barrera, I Porras, G Prete, L Silvestrin, J Wyss. Fast neutrons at LNL Legnaro. Journal of Neutron Research 22 (2-3), 233-247 (2020)
  • I Porras. Applications of neutron optics to biomedicine: BNCT. Advances in Neutron Optics, 239-274 (2019)
  • P Torres-Sánchez, I Porras, FA de Saavedra, MP Sabariego, J Praena. On the upper limit for the energy of epithermal neutrons for Boron Neutron Capture Therapy. Radiation Physics and Chemistry 156, 240-244 (2019)
  • Arias de Saavedra, F., Porras, I., Praena, J. Routes for the production of isotopes for PET with high intensity deuteron accelerators. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 887, pp. 50-53, 2018.
  • J Praena, M Sabaté-Gilarte, I Porras, JM Quesada, S Altstadt, et. al. Measurement and resonance analysis of the 33S(n,alpha)30Si cross section at the CERN n_TOF facility in the energy region from 10 to 300 keV. Physical Review C 97 (6), 064603 (2018).
  • L Damone, M Barbagallo, M Mastromarco, A Mengoni, L Cosentino et al. 7Be(n,p)7Li Reaction and the Cosmological Lithium Problem: Measurement of the Cross Section in a Wide Energy Range at n_TOF at CERN. Physical Review Letters 121 (4), 042701 (2018).
  • Praena, J.,Ferrer, F.J.,Vollenberg, W.,Sabaté-Gilarte, M.,Fernández, B.,García-López, J.,Porras, I., Quesada, J.M., et al. (the n_TOF collaboration) Preparation and characterization of 33S samples for 33S(n,α)30Si cross-section measurements at the n_TOF facility at CERN Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 890, pp.14, 2018.
  • Lerendegui-Marco, J., Guerrero, C., Mendoza, E., (...), Porras, I, Praena J. et al. (the n_TOF collaboration) Radiative neutron capture on Pu242 in the resonance region at the CERN n-TOF-EAR1 facility. Physical Review C97, 024605, 2018
  • I. Porras, T. Wright, S. Bennett, F. Ogállar, J. Praena, M. Sabaté-Gilarte, P. Torres-Sánchez, F. Arias de Saavedra, C. Lederer-Woods, S.J. Lonsdale, R. Garg, M. Dietz and the n_TOF Collaboration. Measurement of the 35Cl(n,g) cross section at n_TOF EAR1. CERN Document Server https://cds.cern.ch/record/2299695/. Proposal CERN-INTC-2018-010/INTC-P-541, endorsed by the INTC, 58th meeting of 7-8/2/2018.
  •  Barbagallo, M., Andrzejewski, J., Mastromarco, M., (...), Porras, I, Praena J. et al. (the n_TOF collaboration) Experimental setup and procedure for the measurement of the7Be(n,p)7Li reaction at n_TOF. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 887, pp. 27-33, 2018.
  • J. Praena, I. Porras, M. Sabaté-Gilarte et al. (the n_TOF collaboration) The 14N(n,p)14C and 35Cl(n,p)35S reactions at n_TOF-EAR2: dosimetry in BNCT and astrophysics. CERN Document Server https://cds.cern.ch/record/2266484 Proposal CERN-INTC-2017-039/INTC-P-510, endorsed by the INTC, meeting of 28-29/7/2017.
  • Sabaté-Gilarte, M., Barbagallo, M., Colonna, N. (...), Porras, I, Praena J. et al. (the n_TOF collaboration) High-accuracy determination of the neutron flux in the new experimental area n_TOF-EAR2 at CERN European Physical Journal A53(10),210 (2017)
  • Sabaté-Gilarte M, Praena J, Porras I, Quesada JM; n_TOF Collaboration. Dose effect of the 33S(n,α)30Si reaction in BNCT using the new n_TOF-CERN data. Radiat Prot Dosimetry. 2017 Sep 23:1-4. doi: 10.1093/rpd/ncx178
  • M.J. Ruiz-Magaña, E. Lucendo, D. Campillo, K. Schulze-Osthoff, and C. Ruiz-Ruiz,The antihypertensive drug hydralazine activates the intrinsic pathway of apoptosis and causes DNA damage in leukemic T cells. Oncotarget. 2016 Apr 19;7(16):21875-86. doi: 10.18632/oncotarget.7871.
  • Barbagallo M, Musumarra A, Cosentino L, Maugeri E, Heinitz S, Mengoni A, Dressler R, Schumann D, Käppeler F, Colonna N, Finocchiaro P, Ayranov M, Damone L, Kivel N, Aberle O, Altstadt S, Andrzejewski J, Audouin L, Bacak M, Balibrea-Correa J, Barros S, Bécares V, Becvár F, Beinrucker C, Berthoumieux E, Billowes J, Bosnar D, Brugger M, Caamaño M, Calviani M, Calviño F, Cano-Ott D, Cardella R, Casanovas A, Castelluccio DM, Cerutti F, Chen YH, Chiaveri E, Cortés G, Cortés-Giraldo MA, Cristallo S, Diakaki M, Domingo-Pardo C, Dupont E, Duran I, Fernandez-Dominguez B, Ferrari A, Ferreira P, Furman W, Ganesan S, García-Rios A, Gawlik A, Glodariu T, Göbel K, Gonçalves IF, González-Romero E, Griesmayer E, Guerrero C, Gunsing F, Harada H, Heftrich T, Heyse J, Jenkins DG, Jericha E, Katabuchi T, Kavrigin P, Kimura A, Kokkoris M, Krticka M, Leal-Cidoncha E, Lerendegui J, Lederer C, Leeb H, Lo Meo S, Lonsdale SJ, Losito R, Macina D, Marganiec J, Martínez T, Massimi C, Mastinu P, Mastromarco M, Mazzone A, Mendoza E, Milazzo PM, Mingrone F, Mirea M, Montesano S, Nolte R, Oprea A, Pappalardo A, Patronis N, Pavlik A, Perkowski J, Piscopo M, Plompen A, Porras I, Praena J, Quesada J, Rajeev K, Rauscher T, Reifarth R, Riego-Perez A, Rout P, Rubbia C, Ryan J, Sabate-Gilarte M, Saxena A, Schillebeeckx P, Schmidt S, Sedyshev P, Smith AG, Stamatopoulos A, Tagliente G, Tain JL, Tarifeño-Saldivia A, Tassan-Got L, Tsinganis A, Valenta S, Vannini G, Variale V, Vaz P, Ventura A, Vlachoudis V, Vlastou R, Vollaire J, Wallner A, Warren S, Weigand M, Weiß C, Wolf C, Woods PJ, Wright T, Žugec P; n_TOF Collaboration. 7Be(n,α)4He Reaction and the Cosmological Lithium Problem: Measurement of the Cross Section in a Wide Energy Range at n_TOF at CERN. Phys Rev Lett. 2016 Oct 7;117(15):152701
  • L. Irazola, J.Praena, B.Fernández, M.Macías, R.Bedogni, J.A.Terrón, B. Sánchez-Nieto, F.Arias de Saavedra, I.Porras and F.Sánchez-Doblado Using a Tandem Pelletron accelerator to produce a thermal neutron beam for detector testing purposes Applied Radiation and Isotopes 107, 330-334, 2016   
  • I. Porras, Editorial. Reports on Practical Oncology and Radiotherapy 21, 93-94, 2016
  • M. Sabaté-Gilarte, J. Praena, I. Porras, J.M. Quesada, P. Mastinu and the n_TOF Collaboration, Measurement of the 33S(n,α) cross-section at n_TOF (CERN): Applications to BNCT. Reports on Practical Oncology and Radiotherapy 21, 113-116, 2016
  • F. Gunsing, O. Aberle, J. Andrzejewski (...), Porras, I, Praena J. et al. (the n_TOF collaboration). Nuclear data activities at the n_TOF facility at CERN. European Physical Journal Plus 131, 371, 2016
  • C.H. Leong, I. Porras and F.W. King, Analysis of atomic integrals involving explicit correlation factors for the three-electron case. I. Connection to the hypergeometric function. Journal of Mathematical Chemistry 54, 1514-1552, 2016
  • G. Martín-Hernández; P. Mastinu; M. Maggiore; L. Pranovi; G. Prete; J. Praena. Excitation function shape and neutron spectrum of the Li7(p,n)Be7 reaction near threshold. Physical Review C. 94, pp. 034620, 2016
  • J. Praena; L. Irazola; B. Fernández; J.A. Terón; R. Bedogni; M. Lorenzoli; A. Pola; B. Sánchez-Nieto; F. Sánchez-Doblado. Proposal of thermal neutron detector stability for peripheral dose estimation in clinac at a novel neutron facility. Radiotherapy & Oncology. 115 - S375, 2015.
  • de Araújo Farias V, O'Valle F, Lerma BA, Ruiz de Almodóvar C, López-Peñalver JJ, Nieto A, Santos A, Fernández BI, Guerra-Librero A, Ruiz-Ruiz MC, Guirado D, Schmidt T, Oliver FJ, Ruiz de Almodóvar JM. Human mesenchymal stem cells enhance the systemic effects of radiotherapy. Oncotarget. 2015 Oct 13;6(31):31164-80. doi: 10.18632/oncotarget.5216.
  • P.C. Lara, J.J. López-Peñalver, V.A. Farías, M.C. Ruiz-Ruiz, F.J. Oliver, and J.M. Ruiz de Almodóvar, Direct and bystander radiation effects: A biophysical model and clinical perspectives. Cancer Lett. 2015 Jan 1;356(1):5-16. doi: 10.1016/j.canlet.2013.09.006.
  • Weiß, E. Chiaveri, S. Girod, V. Vlachoudis, (…) I. Porras, J. Praena et al. (the n_TOF collaboration). The new vertical neutron beam line at the CERN n_TOF facility: design and outlook on the performance. Nuclear Instruments and Methods in Physics Research A 799, 90-98, 2015
  • Praena, I. Porras, M. Sabaté-Gilarte and J. M. Quesada, 33S(n,α)30Si cross section measurement at n_TOF EAR2. CERN Document Server http://cds.cern.ch/record/2021527/files/INTC-P-442.pdf Proposal CERN-INTC-2015-038 ; INTC-I-442, endorsed by the INTC, 50th meeting, 2015
  • I. Porras, J. Praena, F. Arias De Saavedra, M. Pedrosa, P.L. Esquinas and P. Jimenez-Bonilla, Epithermal neutron beams from the Li-7(p,n) reaction near the threshold for neutron capture therapy. Il Nuovo Cimento 38C, 179, 2015.
  • Leno-Durán E, Ruiz-Magaña MJ, Muñoz-Fernández R, Requena F, Olivares EG, Ruiz-Ruiz C. Human decidual stromal cells secrete soluble pro-apoptotic factors during decidualization in a cAMP-dependent manner. Hum Reprod. 2014 Oct 10;29(10):2269-77. doi: 10.1093/humrep/deu202.
  • J. Praena, I. Porras, M. Sabaté-Gilarte, J. M. Quesada, B. Fernández, C. Massimi, F. Mingrone, G. Vannini, P. Woods, C. Lederer, SiMon and Micromegas tests for (n,p) measurements at n_TOF: 35Cl(n,p)35S and 14N(n,p)14C Cross Sections. CERN Document Server http://cds.cern.ch/record/1642805/files/INTC-I-156.pdf Letter of intent CERN-INTC-2014-007, endorsed by the INTC, 46th meeting, 2014
  • J. Praena, M. Sabate-Gilarte, I. Porras, P.L. Esquinas, J.M. Quesada and P.F. Mastinu, Sulfur-33 as a cooperative capturer for BNCT. Applied Radiation and Isotopes 88, 203-205, 2014
  • M.P. Sabariego, I. Porras and A. M. LallenaOn the shape of the Task Group 43 anisotropy factor for linear brachytherapy sources at short distances, Brachytherapy 13, 424-429, 2014
  • I. Porras, M. Sabate-Gilarte, J. Praena, J.M. Quesada and P.L. Esquinas, 33S for neutron capture therapy: nuclear data for Monte Carlo calculations. Nuclear Data Sheets 120, 246-249, 2014
  • J. Praena; P. Mastinu; M. Pignatari; J.M. Quesada; R. Capote; Y. Morilla. Measurement of the MACS of 159Ta(n,g) at kT=30 keV by activation. Nuclear Data Sheets. 120, pp. 205 – 207, 2014.
  • J. Praena; P. Mastinu; M. Pignatari; J.M. Quesada; J. García-López; M. Lozano; N. Dzysiuk; R. Capote; G. Martín-Hernández. Measurement of the MACS of 181Ta(n,g) at kT=30 keV as a test of a method for Maxwellian neutron spectra generation. Nuclear Instruments and Methods in Physics Research A. 727, 1-6, 2013.
  • G Martín-Hernández; P Mastinu; J. Praena; N Dzysiuk; R. Capote-Noy; M Pignatari. Temperature-tuned Maxwell–Boltzmann neutron spectra for kT ranging from 30 up to 50keV for nuclear astrophysics studies. Applied Radiation and Isotopes. 70, pp. 1583 - 1589, 2012.
  • M. Calviani; M. Meaze; N. Colonna; J. Praena; n_TOF Collaboration. The neutron-induced fission cross-section of Cm-245: new results from n_TOF. Physical Review C. 85, pp. 034616, 2012.
  • Rodríguez-Vargas JM, Ruiz-Magaña MJ, Ruiz-Ruiz C, Majuelos-Melguizo J, Peralta-Leal A, Rodríguez MI, Muñoz-Gámez JA, de Almodóvar MR, Siles E, Rivas AL, Jäättela M, Oliver FJ, ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy. Cell Res. 2012 Jul;22(7):1181-98. doi: 10.1038/cr.2012.70
  • Gómez-Millán J, Katz IS, Farias Vde A, Linares-Fernández JL, López-Peñalver J, Ortiz-Ferrón G, Ruiz-Ruiz C, Oliver FJ, Ruiz de Almodóvar JM. The importance of bystander effects in radiation therapy in melanoma skin-cancer cells and umbilical-cord stromal stem cells. Radiother Oncol. 2012 Mar;102(3):450-8. doi: 10.1016/j.radonc.2011.11.002
  • Ruiz-Magaña MJ, Rodríguez-Vargas JM, Morales JC, Saldivia MA, Schulze-Osthoff K, Ruiz-Ruiz C. The DNA methyltransferase inhibitors zebularine and decitabine induce mitochondria-mediated apoptosis and DNA damage in p53 mutant leukemic T cells. Int J Cancer. 2012 Mar 1;130(5):1195-207. doi: 10.1002/ijc.26107.
  • J. Praena, J.M. Quesada, M. Lozano, C. Guerrero, E. Berthoumieux, P. Mastinu, C. Paradela and I. Porras, Micromegas detector for 33S(n,a) cross section measurement at n_TOF. CERN Document Server http://cdsweb.cern.ch/record/1411309 Proposal CERN-INTC-2012-006/INTC-P-322, endorsed by the INTC 42nd meeting, 2012
  • X.J. Juan-Senabre, I. Porras and A. M. Lallena, Monte Carlo Simulation and TG-43 parameters for the I-125 Nucletron SelectSeed brachytherapy source. Radiotherapy and Oncology 99, S175-S175, 2011
  • I. Porras, Sulfur-33 nanoparticles: a Monte Carlo study of their potential as neutron capturers for enhancing Boron Neutron Capture Therapy of cancer. Applied Radiation and Isotopes 69, 1838-1841, 2011
  • Hatta K, Carter AL, Chen Z, Leno-Durán E, Ruiz-Ruiz C, Olivares EG, Tse MY, Pang SC, Croy BA. Expression of the vasoactive proteins AT1, AT2, and ANP by pregnancy-induced mouse uterine natural killer cells. Reprod Sci. 2011 Apr;18(4):383-90. doi: 10.1177/1933719110385136.
  • Ruiz-Ruiz C, Srivastava GK, Carranza D, Mata JA, Llamas I, Santamaría M, Quesada E, Molina IJ. An exopolysaccharide produced by the novel halophilic bacterium Halomonas stenophila strain B100 selectively induces apoptosis in human T leukaemia cells. Appl Microbiol Biotechnol. 2011 Jan;89(2):345-55. doi: 10.1007/s00253-010-2886-7.
  • R. Sarmento; M. Calviani; J. Praena; N. Colonna; n_TOF Collaboration. Measurement of the 236U(n,f) cross section from 170 meV to 2 MeV at the CERN n_TOF facility. Physical Review C. 84 – 044618, 2011.
  • Colonna; F. Belloni; E. Berthoumieux; M. Calviani; C. Domingo-Pardo; C. Guerrero; D. Karamidos; C. Lederer; C. Massimi; C. Paradela; R. Plag; J. Praena; R. Sarmento. Advanced nuclear energy systems and the need of accurate nuclear data: the n_TOF project at CERN. Energy & Environmental Science. 3, pp. 10910, 2010
  • Morales JC, Ruiz-Magaña MJ, Carranza D, Ortiz-Ferrón G, Ruiz-Ruiz C. HDAC inhibitors with different gene regulation activities depend on the mitochondrial pathway for the sensitization of leukemic T cells to TRAIL-induced apoptosis. Cancer Lett. 2010 Nov 1;297(1):91-100. doi: 10.1016/j.canlet.2010.04.029.
  • Leno-Durán E, Hatta K, Bianco J, Yamada AT, Ruiz-Ruiz C, Olivares EG, Croy BA. Fetal-placental hypoxia does not result from failure of spiral arterial modification in mice. Placenta. 2010 Aug;31(8):731-7. doi: 10.1016/j.placenta.2010.06.002.
  • Hatta K, Chen Z, Carter AL, Leno-Durán E, Zhang J, Ruiz-Ruiz C, Olivares EG, MacLeod RJ, Croy BA. Orphan receptor kinase ROR2 is expressed in the mouse uterus. Placenta. 2010 Apr;31(4):327-33. doi: 10.1016/j.placenta.2010.01.012
  • J. Praena, P. Mastinu, S. Andriamonje, J.M. Quesada, M. Lozano and I. Porras, Micromegas performance test for (n,alpha) measurements at n-TOF: 33S(n,alpha) cross section. CERN Document Server: http://cdsweb.cern.ch/record/1266288 CERN-INTC-2010-023/I-092 Letter of Intent, endorsed by INTC committee 37th meeting, 2010
  • I. Porras and F. Cordobés-Aguilar, Study of a generalized Levin–Weniger convergence accelerator of numerical series: Particular cases and applications to multi-electron integrals in atomic physics. Applied Numerical Mathematics 60, 1371-1381, 2010
  • P. Mastinu; G. Martín-Hernández; J. Praena. A new method to obtain a Maxwell-Boltzmann neutron spectrum for astrophysics studies. Nuclear Instruments and Methods in Physics Research A. 601, pp. 333 – 338, 2009.
  • I. Porras, Tests and applications for atoms of an optimized semiexplicit density functional method. Journal of Mathematical Chemistry 46, 795-810, 2009
  • Blanco O, Leno-Durán E, Morales JC, Olivares EG, Ruiz-Ruiz C. Human decidual stromal cells protect lymphocytes from apoptosis. Placenta. 2009 Aug;30(8):677-85. doi: 10.1016/j.placenta.2009.05.011.
  • I. Porras, Exploring a Boron-Sulphur Neutron Capture Therapy, in Book: A new option against cancer Proceedings of the 13th International Congress on Neutron Capture Therapy (ISBN: 88-8286-167-8) ENEA, Italian Nacional Agency for New Technologies, Energy and the Environment 719-720, 2008
  • M.P. Sabariego, I. Porras and A. Lallena, Simple analytical expressions for the dose of point photon sources in homogeneous media, Physics in Medicine and Biology 53, 6113-6128, 2008
  • I. Porras, Enhancement of neutron radiation dose by the addition of sulphur-33 atoms.Physics in Medicine and Biology 53, L1 -L9, 2008
  • Morales JC, Ruiz-Magaña MJ, Ruiz-Ruiz C. Regulation of the resistance to TRAIL-induced apoptosis in human primary T lymphocytes: role of NF-kappaB inhibition. Mol Immunol. 2007 Apr;44(10):2587-97