Scholarly monograph · Open access · HTML edition
Targets, Therapies and the Dilemmas of Healthy Longevity
A book about the most universal of human experiences, written at the moment when that experience may, for the first time, be becoming negotiable.
For almost the whole of recorded history, ageing was a fixed coordinate of the human condition — something to be endured, interpreted or transcended, but not altered. The biology of the past two decades has begun to unsettle that assumption. We can now measure ageing, identify several of the molecular processes that drive it, and — in laboratory animals — slow, halt or partially reverse some of them.
These pages give a careful, current and honest account of that shift. The field crossed a symbolic threshold while the book was being written: therapies based on cellular reprogramming, the deliberate partial rewinding of a cell's biological age, moved from the mouse towards the first human and ex vivo studies. Written in that interval — where the science is real, the translation uncertain, and the claims most in need of disciplined scrutiny — the text takes seriously the distinction between extending lifespan and extending healthspan, the years lived in good health.
It is written for advanced undergraduate and postgraduate readers and assumes no background in molecular biology or medicine. Specialists will find the references and the critical apparatus; newcomers will find the bridges.
The biology and medicine of ageing: mechanisms, targets, therapies, biomarkers and the design of longevity trials.
Demography, economics and distributive justice, ethics, and the wider philosophical debate on convergent nano-bio-info-cognitive enhancement.
Peer-reviewed primary literature, concentrated in the most recent decade and weighted towards Cell, Nature, Science and the major review series. Every reference checked against its primary record.
Quarto HTML with light/dark themes, collapsible technical asides, runnable R simulation boxes, a hyperlinked glossary and a single consolidated bibliography.
Five parts and fifteen chapters move from molecular mechanism to medicine to society, framed by a preface, an introduction and an epilogue.
@book{moreno2026reversible,
author = {Moreno, Miguel},
title = {Reversible Ageing: Targets, Therapies and
the Dilemmas of Healthy Longevity},
year = {2026},
publisher = {Zenodo},
doi = {10.5281/zenodo.20745513},
url = {https://utilizas.github.io/ageing/},
note = {CC BY-NC-SA 4.0}
}
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the open-access edition
utilizas.github.io/ageing