MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01C7842C.6DCF0620" Este documento es una página Web de un solo archivo, también conocido como archivo de almacenamiento Web. Si está viendo este mensaje, su explorador o editor no admite archivos de almacenamiento Web. Descargue un explorador que admita este tipo de archivos, como Microsoft Internet Explorer. ------=_NextPart_01C7842C.6DCF0620 Content-Location: file:///C:/E31BBA37/sangre2-2006-07.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Trombosis. Fármacos Antitrombóticos.

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=
=
=
OBJETIVOS DEL TEMA
1.- Valorar la influencia de las reacciones adversas de la clinico
2.- Analizar las causas que dificultan en la práctica el= uso de los anticoagulantes orales.
3.-farmacologico= de los diferentes fibrinoliticos.
4.- Asumir el verdadero papel de los antiagregantes plaquetarios en la práctica clínic= a.
FARMACOLOGIA DE LA SANGRE
SINDROME TROMBOTICO<= /span>
3D"VOLVER
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FARMACOS ANTICOAGULANTES
HEPARINA. REACCIONES ADVERSAS = ;
•H= EMORRAGIAS:
•(HEMATURIA, MELENAS, EQUIMOSIS, ETC)
•- LEVES:
•      + CORREGIR LA DOSIFICACION.
•- GRAVES:
•      + PLASMA HUMANO. = 3;
•         (FRESCO, <5 DIAS, MEJOR)
•      = + PROTAMINA: (ANTIDOTO)
•        = ;     - PROTEINA BASICA.
•        = ;     - 1 mg =3D 100 U.I. DE HEPARINA
•        = ;       CIRCULANTE.
•        = ;     - TITULACION "IN VITRO".
•        = ;     - ACTIVIDAD ANTICOAGULANTE
•        = ;       PROPIA.
•        = ;     - ADMINIS. I.V. LENTA
•        = ;       (LIBERA = HISTAMINA).
3D"VOLVER
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FARMACOS ANTICOAGULANTES
HEPARINA. REACCIONES ADVERSAS = ;
•T= ROMBOCITOPENIA:(POR HIPERCONSUMO)
•   - LEVE:
•       + EN EL 25% DE LOS ENFERMOS.
•       + EN LOS PRIMEROS DIAS DE TRAT.
•       + MECANISMO DESCONOCIDO.
•       + NO AUMENTA O DESAPARECE SOLA.
•
•   - GRAVE:
•       + RARA. TRAS = 5-15 DIAS DE TRAT.
•       + COMPLEJO:   &= #13;
•<= b>IgG ANTIPLAQUETA-H= EPARINA-PLAQUETA
•<= span style=3D'mso-spacerun:yes'>       + AGREGACION IRREVERSIBLE.
•       + COMPLICACIONES TROMBO-
•        = ;  EMBOLICAS DIVERSAS.
•       + RECUENTO DE PLAQUETAS CADA
•        = ;  (3-6 DIAS).
3D"VOLVER
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FARMACOS ANTICOAGULANTES
HEPARINA. REACCIONES ADVERSAS = ;
•R= EACCIONES ALERGICAS:
•- ERUPCIONES
•- RINITIS. FIEBRE
•- ANAFILAXIS. BRONCOSPASMO.
•- POR ORIGEN ANIMAL
•- TEST DE SENSIBILIDAD PREVIO
•       (SI HAY ANTECEDENTES ALERGICOS)
•O= STEOPOROSIS:
•   - EN TRATAMIENTOS PROLONGADOS 
•      = (6 MESES O MAS).
•   - MECANISMO DESCONOCIDO.
•   - HEPARINA Y EMBARAZO.
•   - NO ATRAVIESA PLA= CENTA: TRAT.ELEC.
•HEPAR= INAS DE BAJO PESO MOLECULAR:
•CUANTITATIVAMENTE MEJOR TOLERADAS
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FARMACOS ANTICOAGULANTES
HEPARIN= A.
•I= NDICACIONES:
• ENFERMEDADES TROMBOEMBOLICAS.
•N= ORMAS PRACTICAS DE EMPLEO:
•-= A DOSIS BAJAS: (PROFILAX= IS)
•       + NO NECESITA CONTROLES DE
•        = ;  COAGULACION. MANEJO FACIL.
•-= A DOSIS PLENAS:
•  + MANEJO CRITICO. MUY ACTIVA.
•  + INICIO Y FIN DE ACCION RAPIDOS.
•  + RANGO TERAPEUTICO ESTRECHO.
•  + RELACION DOSIS-EFECTO POBRE.
•  + TEST DEL TTPA EXPRESADO COMO:
•         - RELACION PACIENTE/CONTROL
•         - TTPA-R ENTRE 1.5 Y 2.5.
•         - BUENA CORRELACION CON NIVELES EN SANGRE DE HEPARINA.
•         + DURACION TRAT. ENTRE 7 Y 15 DIAS. =
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=
•F= ARMACOCINETICA:
•   - BUENA ABSORCION POR VIA ORAL.
•<= span style=3D'mso-spacerun:yes'>   - UNION A PROTEINAS DEL 99%. PELIGRO
•<= span style=3D'mso-spacerun:yes'>      DE INTERACCIONES.
•<= span style=3D'mso-spacerun:yes'>   - METABOLISMO HEPATICO. = ;
•<= span style=3D'mso-spacerun:yes'>   - VIDA MEDIA LARGA. DE 1 A = VARIOS DIAS
•<= span style=3D'mso-spacerun:yes'>   - ADMINISTRACION 1 VEZ AL D= IA.
•C= UMARINAS:
•      ACENOCUMAROL. WARFAR= INA
•M= ECANISMO DE ACCION:
• - TROMBOSTATICOS.
• - ANTIVITAMINAS K:
•    + ANTAG. COMP. ENZIMAS HEPATICAS.&#= 13;
•<= span style=3D'mso-spacerun:yes'>    + NO SINTESIS FACTORE= S  II, VII, IX, X.=
• - EFECT. ANTICOAG. RETARDA= DO: 12-24 H.
• - NO ACTIVOS "IN VITRO".
F= ARMACOS ANTICOAGULANTES
ANT= ICOAGULANTES ORALES <= /span>
3D"VOLVER
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ACgAggAAAJkAAM0AAP8AAP8yMv9mZgECAwECAwPNWLTc/jCyoqS9L9CKewza5o0NGIqkZ55oaq1s 62bwZhdDru98v8Og28ZHLA6AsaFxqUMKKcyo8xllToXVXIB4vWVNvq6tCuuJlUsk7wxtgtdveI3q BpnjP+ATV9/K/X8me3l2f2F6dFp4ioWBQYlHi5GNhCuDlYZ3c1iVgGWalpCTSJSdj5ymn6CCooxA RWx8h6WzoahZtay3uI5Jbbyrp17Awb6yxH26NgLMzc7P0NCIy9HV1s6bFNfb17YF3ODVuuHk0iHl 6Njf6ewCCQA7 ------=_NextPart_01C7842C.6DCF0620 Content-Location: file:///C:/E31BBA37/sangre2-2006-07_archivos/slide0032.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Trombosis. Fármacos Antitrombóticos.
FARMACOS ANTICOAGULANTES
ANTICOA= GULANTES ORALES <= /span>
•F= ACTORES QUE MODIFICAN SU
•A= CTIVIDAD:
•-= MUY NUMEROSOS:
•     DIETETICOS, CLINICOS, MEDICAMENT.
•-= EN AMBOS SENTIDOS:
•     HEMORRAGIAS O INEFICACIA.
•- MANEJO CRITICO. =
•R= EACCIONES ADVERSAS:
•- HEMORRAGIAS:=
•      + POR INADECUADO CON= TROL
•         DEL TRATAMIENTO.
•- LEVES: VITAMINA K
•      = (TARDA 12 HORAS EN ACTUAR).
•- GRAVES:
•      + VITAMINA K= I.V.  DOSIS MAXIMAS
•      + CONCENTRADOS DE FACTORES
•         DEFICITARIOS.
3D"VOLVER
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= =
FARM= ACOS ANTICOAGULANTES
ANTICO= AGULANTES ORALES <= /span>
•C= ONTROL DEL TRATAMIENTO:
•   - GRADO DE ANTICOAGULACION:
•       + TIEMPO DE PROTROMBINA
•        = ;   EXPRESADO EN UNIDADES I.N.R.
•       + ANTICOAGULACION OPTIMA
•<= span style=3D'mso-spacerun:yes'>        = ;   I.N.R. ENTRE 2 Y 3.
•   - CONTROL DIARIO HASTA FASE MESETA
•   - DESPUES UNA VEZ = AL MES.
•   - INFLUENCIA DE LA= VIDA MEDIA LARGA
•     EN EL TRATAMIENTO.
•I= NDICACIONES:  LAS DE LA HEPARINA.
•   - INICIO CON HEPARINA.
•   - CONTINUAR CON AN= TIC. ORALES.
•   - TRATAMIENTO INDE= FINIDO SI FUERA
•       NECESARIO.
3D"VOLVER
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FARMACOS FIBRINOLITICOS
•DISGREGAN LA FIBRINA YA FORMADA.
•E= STREPTOKINASA Y ANISTREPLASA:
•- ACTIVADOR INDIRECTO DEL PLASMINO-
•  GENO.
•- COMPLEJO INICIAL  1:1= 3;
•      = ESTREPTOKINASA-PLASMINOGENO.
•- CONVERSION A:
•      ESTREPTOKINASA-PLASMINA
•- CONVERSION DEL RESTO DEL
•   PLASMINOGENO A PLASMINA.
•- DIFICIL CONTROL (UVI):ESTADO DE
•        = ;          HIPERPLASMINEMI= A.
•- EN CASO DE HEMORRAGIAS:
•        = ;   SANGRE Y ANTIFIBRINOLITICOS.
•- REACCIONES ALERGICAS FRECUENTES.
3D"VOLVER
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= FARMACOS FIBRINOLITICOS
MECANIS= MO DE ACCION
FACTORES<= br> COAGULACION
PLASMINOGENO
PLASMINA
FIBRINA
FIBRINOLISIS
ACTIVADOR
PLASMATICO
FARMACOS
FIBRINOLITICOS
INHIBIDORES
= NATURALES
t - PA
ACTIVADOR
TISULAR
ENDOTELIO
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Fármacos Antitrombóticos.
FARMACOS FIBRINOLITICOS
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•  SISTEMICA.
3D"VOLVER
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FOSFODIESTERASA=
MECANISMOS DE LA AGREGACION PLAQUETARIA
COLAGENO
= ADP
ADRENALINA
TROMBINA
5-HT
VASOPRESINA
ANGIOTENSINA
AGREGACION
TxA2
AMPc
AMP
ATP
ADENILCICLASA<= span style=3D'mso-special-format:lastCR;display:none'>
PGI2
LIBERACION
PLAQUETAS
A.ARAQUIDONICO
A.ARAQUIDONICO
PROSTAGLANDINAS
PROSTAGLANDINAS
TROMBOXANO A2
PROSTACICLINA<= span style=3D'mso-special-format:lastCR;display:none'>
CICLOOXIGENASA
PARED VASCULAR=
ANTIAGREGANTES PLAQUETARIOS
(-)
GP IIb/IIIa
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file:///C:/E31BBA37/sangre2-2006-07_archivos/slide0037.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Trombosis. Fármacos Antitrombóticos.
ANTIAGREGANTES PLAQUETARIOS
•A= SPIRINA: ACIDO ACETIL SALICILICO
•- INHIBICION DE LA COX:
•  + PAPEL DE LA VIA ORAL Y
•      SISTEMA PORTAL.
•  + DIFERENCIAS CAPACIDAD = DE SINTESIS
•     DE COX= EN PLAQUETAS Y PARED
•     VASCULAR.
•   - DOSIS BAJ= AS DE ASPIRINA
•        = ;    (75 - 300 mg/dia):
•     + INHIBICION PREFERE= NTE COX PLAQ.= 3;
•   - DOSIS ALT= AS DE ASPIRINA:
•     + INHIBICION COX PLA= QUETAR Y PARED
•      &n= bsp; VASCULAR.
•   - INHIBICION IRREVERSIBLE.
•TRIFU= SAL: DERIVADO DE LA A.A.S= .
•   - MAYOR SELECTIVIDAD POR COX PLAQ.
•   - INHIBICION FOSFODIESTERASA PLAQ.
3D"VOLVER
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ANTIAGREGANTES PLAQUETARIOS
•DIPIR= IDAMOL:
•1- INHIBE FOSFODIES= TERASA PLAQUET= ARIA
•2- INHIBE CAPTACION FISIOLOGICA DE ADE-
•    NOSINA CIRCULANTE POR HEMA= TIES Y
•    ENDOTELIO:&#= 13;
•   + ADENOSINA ESTIMU= LA ADENILCICLASA
•      PLAQUETARIA.
•   + ESTABILIZA LA PL= AQUETA FRENTE A
•      AGREGANTES.
•   + UTIL EN COMBINAC= ION CON ASPIRINA.
•INTER= ES ACTUAL ANTIAGREGANTES
• - PROFILAXIS Y TRATA= MIENTO TROMBOSIS
•      ARTERIAL.
•- EFICACIA EN CONTINUA EVALUACION.
• - OTROS:
• TICLOPIDINA, CLOPIDOGREL, ABCIXIMAB,
•<= span style=3D'mso-spacerun:yes'>  EPOPROSTENOL, ILOPROST.
3D"VOLVER
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RESUMEN:
1.- LA HEMORRAGIA ES LA COMPLICACION MAS FRECUENTE DE= L USO DE HEPARINAS .
2.- LOS ANTICOAGULANTES ORALES <= /b>REQUIEREN UN CONTROL ESTRICTO= DEL TRATAMIENTO. <= /span>
3.- LOS FIBRINOLITICOS SON FARMA= COS DE USO RESTRINGIDO. <= /span>
4.- LA EVALUACION DE LA UTILIDAD= REAL DE LOS ANTIAGREGANTES PLAQUETARIOS AUN NO HA ACABADO.
FARMACOLOGIA DE LA SANGRE
SINDROME TROMBOTICO<= /span>
3D"VOLVER
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BIBLIOGRAFIA:
1.- J.Flóre= z
Farmacologia Humana
4ª Edicion 2003.
FARMACOLOGIA DE LA SANGRE
SINDROME TROMBOTICO<= /span>
3D"VOLVER
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bmU7DQoJbXNvLWFuc2ktbGFuZ3VhZ2U6RVMtVFJBRDt9DQphOmxpbmsNCgl7Y29sb3I6I0NDQ0NG RiAhaW1wb3J0YW50O30NCmE6YWN0aXZlDQoJe2NvbG9yOiMzMzMzQ0MgIWltcG9ydGFudDt9DQph OnZpc2l0ZWQNCgl7Y29sb3I6I0IyQjJCMiAhaW1wb3J0YW50O30NCn== ------=_NextPart_01C7842C.6DCF0620 Content-Location: file:///C:/E31BBA37/sangre2-2006-07_archivos/script.js Content-Transfer-Encoding: quoted-printable Content-Type: application/javascript; charset="us-ascii" function LoadSld() { var sld=3DGetObj("SlideObj") if( !g_supportsPPTHTML ) { =09 sld.style.visibility=3D"visible" return } if( MakeNotesVis() ) return runAnimations =3D _InitAnimations(); =09 if( IsWin("PPTSld") ) parent.SldUpdated(GetSldId()) g_origSz=3DparseInt(SlideObj.style.fontSize) g_origH=3Dsld.style.posHeight g_origW=3Dsld.style.posWidth g_scaleHyperlinks=3D(document.all.tags("AREA").length>0) if( g_scaleHyperlinks ) InitHLinkArray() if( g_scaleInFrame||(IsWin("PPTSld") && parent.IsFullScrMode() ) ) document.body.scroll=3D"no" _RSW() if( IsWin("PPTSld") && parent.IsFullScrMode() ) FullScrInit(); =09 MakeSldVis(); ChkAutoAdv() if( runAnimations ) { if( document.all("NSPlay") ) document.all("NSPlay").autoStart =3D false; if( sld.filters && sld.filters.revealtrans ) setTimeout( "document.body.start()", sld.filters.revealtrans.duration * = 1000 ); else document.body.start(); } } function MakeSldVis()=20 { var fTrans=3Dg_showAnimation && SldHasTrans() if( fTrans )=09 { if( g_bgSound ) { idx=3Dg_bgSound.indexOf(","); pptSound.src=3Dg_bgSound.substr( 0, idx ); pptSound.loop=3D -(parseInt(g_bgSound.substr(idx+1))); } SlideObj.filters.revealtrans.Apply()=09 } SlideObj.style.visibility=3D"visible" if( fTrans ) SlideObj.filters.revealtrans.Play() } function MakeNotesVis()=20 { if( !IsNts() ) return false=20 SlideObj.style.display=3D"none" nObj =3D document.all.item("NotesObj") parent.SetHasNts(0) if( nObj ) {=20 nObj.style.display=3D"" parent.SetHasNts(1) } return 1 } function ChkAutoAdv() { if(SldHasTrans()) SlideObj.onfilterchange=3DAutoAdv else AutoAdv() } function AutoAdv() { if(!IsWin("PPTSld") || !gUseSldTimings )return var sld=3DGetCurSld() if( (sld.mAdvDelay>0) && !parent.IsFramesMode() ) setTimeout("parent.GoToNextSld()",sld.mAdvDelay) } function GetObj(id) { if(g_supportsPPTHTML) return document.all(id); else return document.getElementById(id); } function SldHasTrans() { return SlideObj.style.filter !=3D ""; } function GetSldId() { return sId=3Dlocation.href.substring(location.href.la= stIndexOf('/')+1) } function HideMenu() { if( frames["PPTSld"] && PPTSld.document.all.item("ctx= tmenu") && PPTSld.ctxtmenu.style.display!=3D"none" ) { PPTSld.ctxtmenu.styl= e.display=3D'none'; return true } return false } function IsWin( name ) { return window.name =3D=3D name } function IsNts() { return IsWin("PPTNts") } function IsSldOrNts() { return( IsWin("PPTSld")||IsWin("PPTNts") ) } function SupportsPPTAnimation() { return( navigator.platform =3D=3D "Win32"= && navigator.appVersion.indexOf("Windows")>0 ) } function SupportsPPTHTML() { var appVer=3Dnavigator.appVersion, msie=3DappVer.indexOf("MSIE "), ver=3D0 if( msie >=3D 0 ) ver=3DparseFloat( appVer.substring( msie+5, appVer.indexOf(";",msie) ) ) else ver=3DparseInt(appVer) return( ver >=3D 4 && msie >=3D 0 ) } function _RSW() { if( !g_supportsPPTHTML || IsNts() || ( !g_scaleInFrame && (!IsWin("PPTSld") || !parent.IsFullScrMode()) ) ) return var padding=3D0; if( IsWin("PPTSld") && parent.IsFramesMode() ) padding=3D6 cltWidth=3Ddocument.body.clientWidth-padding cltHeight=3Ddocument.body.clientHeight-padding factor=3D(1.0*cltWidth)/g_origW if( cltHeight < g_origH*factor ) factor=3D(1.0*cltHeight)/g_origH newSize =3D g_origSz * factor if( newSize < 1 ) newSize=3D1 s=3DSlideObj.style s.fontSize=3DnewSize+"px" s.posWidth=3Dg_origW*factor s.posHeight=3Dg_origH*factor s.posLeft=3D(cltWidth-s.posWidth+padding)/2 s.posTop=3D(cltHeight-s.posHeight+padding)/2 if( g_scaleHyperlinks ) ScaleHyperlinks( factor ) } function _InitAnimations() { animRuntimeInstalled =3D ''+document.body.localTime !=3D 'undefined'; isFullScreen =3D (window.name =3D=3D "PPTSld") && !parent.IsFramesMode(); g_animUseRuntime =3D g_showAnimation && animRuntimeInstalled && !(isFullSc= reen && parent.IsSldVisited()); if( g_animUseRuntime ) { collSeq =3D document.all.tags("seq"); if( collSeq !=3D null ) { for(ii=3D0;ii numSlds ) gSldJumpIdx =3D numSlds; if ( gSldJumpIdx >=3D 0 ) { if ( gSldJumpIdx =3D=3D 0 ) gSldJumpIdx =3D 1; var jumpTo =3D parseInt(gSldJumpIdx); gSldJump =3D 0; gSldJumpIdx =3D ""; win.GoToSld( parent.GetSldList().mList[jumpTo-1].mSldHref ) } } } function _KDH() { if( event.keyCode =3D=3D 8 ) { event.returnValue =3D 0; parent.GoToPrevSld(); } } var g_HLinkArray =3D new Array(); =20 function IMapAreaObj( areaObj, coords ) { this.areaObj =3D areaObj; this.coords =3D coords; } function InitHLinkArray() { var appVer =3D navigator.appVersion; var msie =3D appVer.indexOf ( "MSIE " ) var ver =3D 0; if ( msie >=3D 0 ) ver =3D parseInt ( appVer.substring( msie+5 ) ); linkNum =3D 0; for (i=3D0; i 4 ) ) g_HLinkArray[linkNum++] =3D new IMapAreaObj( areaObj, ParseCoords( ar= eaObj.coords ) ); } } function ScaleHyperlinks( factor ) { =20 for ( ii=3D0; ii< g_HLinkArray.length; ii++) { coordsStr=3D""; imaObj =3D g_HLinkArray[ii]; for ( jj=3D0; jj < imaObj.coords.length-1; jj++ ) coordsStr +=3D (imaObj.coords[jj]*factor) + ","; coordsStr +=3D (imaObj.coords[jj]*factor); imaObj.areaObj.coords =3D coordsStr; } } function ParseCoords( coordsStr ) { var numArray =3D new Array(); var i =3D curPos =3D commaPos =3D 0; while ( ( commaPos =3D coordsStr.indexOf(",", curPos) ) !=3D -1 ) {=20 numArray[i++] =3D parseInt( coordsStr.substr( curPos, commaPos ) ); curPos =3D commaPos + 1; } numArray[i] =3D parseInt( coordsStr.substr( curPos ) ); return numArray; } function DocumentOnClick() { if( IsNts() || parent.HideMenu() ) return; if( ( g_allowAdvOnClick && (window.name=3D=3D"PPTSld") && !parent.IsFrames= Mode() ) || (event && event.keyCode=3D=3D32) ) { =09 if( g_animUseRuntime && g_animMainSequence && g_animMainSequence.cangonex= t ) return; parent.GoToNextSld(); } } var g_supportsPPTHTML =3D SupportsPPTHTML(), g_scaleInFrame =3D 1, gId=3D""= , g_bgSound=3D"", g_scaleHyperlinks =3D false, g_allowAdvOnClick =3D 1, g_showInBrowser = =3D 1, gLoopCont =3D 0, gUseSldTimings =3D 0; var g_showAnimation =3D g_supportsPPTHTML && SupportsPPTAnimation() && ( (w= indow.name=3D=3D"PPTSld" && !parent.IsFramesMode()) || g_showInBrowser );va= r g_animManager =3D null; var g_animUseRuntime =3D false; var g_animItemsToHide, g_animInteractiveItems, g_animSlideTime; var g_animMainSequence =3D null; var ENDSHOW_MESG=3D"Fin de la presentación, haga clic para salir.", = SCREEN_MODE=3D"Frames", gIsEndShow=3D0, NUM_VIS_SLDS=3D17, SCRIPT_HREF=3D"s= cript.js", FULLSCR_HREF=3D"fullscreen.htm"; var gCurSld =3D gPrevSld =3D 1, g_offset =3D 0, gNtsOpen =3D gHasNts =3D gO= tlTxtExp =3D 0, gHasNarration =3D 0, gOtlOpen =3D true window.gPPTHTML=3DSupportsPPTHTML() var gMainDoc=3Dnew Array(new hrefList("slide0041.htm",1,-1,1),new hrefList(= "slide0026.htm",1,-1,1),new hrefList("slide0027.htm",1,-1,1),new hrefList("= slide0028.htm",1,-1,1),new hrefList("slide0046.htm",1,-1,1),new hrefList("s= lide0030.htm",1,-1,1),new hrefList("slide0044.htm",1,-1,1),new hrefList("sl= ide0032.htm",1,-1,1),new hrefList("slide0047.htm",1,-1,1),new hrefList("sli= de0034.htm",1,-1,1),new hrefList("slide0045.htm",1,-1,1),new hrefList("slid= e0035.htm",1,-1,1),new hrefList("slide0036.htm",1,-1,1),new hrefList("slide= 0037.htm",1,-1,1),new hrefList("slide0038.htm",1,-1,1),new hrefList("slide0= 042.htm",1,-1,1),new hrefList("slide0043.htm",1,-1,1)); /********************************************* Frameset functions These functions control slide navigation and state of the frameset. **********************************************/ function FullScrInit() { g_allowAdvOnClick =3D GetCurSld().mAdvOnClk document.body.style.backgroundColor=3D"black" document.oncontextmenu=3Dparent._CM; document.onkeydown =3D _KDH; document.ondragstart=3DCancel document.onselectstart=3DCancel self.focus() } function Redirect( frmId ) {=09 var str=3Ddocument.location.hash,idx=3Dstr.indexOf('#'), sId=3DGetSldId() if(idx>=3D0) str=3Dstr.substr(1); if( window.name !=3D frmId && ( sId !=3D str) ) { obj =3D GetObj("Main-File") window.location.href=3Dobj.href+"#"+sId return 1 } return 0 } var MHTMLPrefix =3D CalculateMHTMLPrefix();=20 function CalculateMHTMLPrefix() { if ( document.location.protocol =3D=3D 'mhtml:') {=20 href=3Dnew String(document.location.href)=20 Start=3Dhref.indexOf('!')+1=20 End=3Dhref.lastIndexOf('/')+1=20 if (End < Start)=20 return href.substring(0, Start)=20 else=20 return href.substring(0, End)=20 } return ''; } function GetTags(base,tag) { if(g_supportsPPTHTML) return base.all.tags(tag); else return base.getElementsByTagName(tag); } function UpdNtsPane(){ if(frames["PPTNts"]) PPTNts.location.replace( MHTMLP= refix+GetHrefObj( gCurSld ).mNtsHref ) } function UpdNavPane( sldIndex ){ if(gNavLoaded) PPTNav.UpdNav() } function UpdOtNavPane(){ if(gOtlNavLoaded) PPTOtlNav.UpdOtlNav() } function UpdOtlPane(){ if(gOtlLoaded) PPTOtl.UpdOtl() } function SetHasNts( fVal ) { if( gHasNts !=3D fVal ) { gHasNts=3DfVal UpdNavPane() } } function ToggleOtlText() { gOtlTxtExp=3D!gOtlTxtExp UpdOtlPane() } function ClearMedia() { // Clear any sounds playing before launching another browser window. Other= wise, // in fullscreen mode, you'll continue to hear the sound in the frames mod= e. if (PPTSld.pptSound) PPTSld.pptSound.loop =3D 0; } function FullScreen() {=20 if ( PPTSld.g_animUseRuntime ) PPTSld.document.body.pause(); ClearMedia(); var href =3D ( document.location.protocol =3D=3D 'mhtml:') ? FULLSCR_HREF = : FULLSCR_HREF+"#"+GetHrefObj(gCurSld).mSldHref; if(PPTNav.event.ctrlKey) { var w =3D (window.screen.availWidth * 1.0) / 2.0 var h =3D w * (PPTSld.g_origH * 1.0) / PPTSld.g_origW win =3D window.open( MHTMLPrefix+href,null,"toolbar=3D0,resizable=3D1,top= =3D0,left=3D0," + "width=3D"+ w + ",height=3D" + h ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } else { win =3D window.open( MHTMLPrefix+href,null,"fullscreen=3Dyes" ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } } function ToggleVNarration() { rObj=3DPPTSld.document.all("NSPlay") if( rObj && !PPTSld.g_animUseRuntime ) { if( (rObj.playState =3D=3D 1)||(rObj.playState =3D=3D 0) ) rObj.Play() else if( rObj.playState =3D=3D 2 ) rObj.Pause() else return; } else if( PPTSld.g_animUseRuntime ) { narObj =3D PPTSld.document.all("narrationID") if( narObj ) narObj.togglePause() } } function GetCurSldNum() { =20 obj=3DGetHrefObj(gCurSld) if( obj.mOrigVis =3D=3D 1 ) return obj.mSldIdx else =20 return gCurSld } function GetNumSlds() { =20 if( GetHrefObj(gCurSld).mOrigVis =3D=3D 1 ) return GetSldList().mNumVisSlds; else return GetSldList().mList.length } function GetSldNum( href ) { for(ii=3D0; ii 1 ) PopSldList(); else if( !IsFramesMode() ) { if( gLoopCont ) GoToFirst() else EndShow() } } function GoToPrevSld() { ii=3DgCurSld-1 if( ii > 0 ) { obj=3DGetHrefObj(ii) while ( obj && ( obj.mVis =3D=3D 0 ) && ( ii>0 ) ) obj=3DGetHrefObj(--ii) if( ii =3D=3D 0 ) ii=3D1 GoToSldNum(ii) } } function GoToFirst(){ GoToSld( GetHrefObj(1).mSldHref ) } function GoToLast() { ii=3DGetSldList().mList.length if( ii !=3D gCurSld ) GoToSld( GetHrefObj(ii).mSldHref ) } function GoToSldNum( num ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue obj =3D GetHrefObj( num ) obj.mVis=3D1 gPrevSld=3DgCurSld gCurSld =3D num; PPTSld.location.replace(MHTMLPrefix+obj.mSldHref) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function GoToSld( href ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue GetHrefObj( GetSldNum(href) ).mVis=3D1 PPTSld.location.replace(MHTMLPrefix+href) } function SldUpdated( id ) { if( id =3D=3D GetHrefObj(gCurSld).mSldHref ) return gPrevSld=3DgCurSld gCurSld=3DGetSldNum(id) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function PrevSldViewed(){ GoToSld( GetHrefObj(gPrevSld).mSldHref ) } function HasPrevSld() { return ( gIsEndShow || ( gCurSld !=3D 1 && GetHrefO= bj( gCurSld-1 ).mVis =3D=3D 1 )||( GetCurSldNum() > 1 ) ) } function HasNextSld() { return (GetCurSldNum() !=3D GetNumSlds()) } function CloseWindow() { if( HideMenu() ) return; =09 var event =3D PPTSld.event; if( !IsFramesMode() && event && (event.keyCode=3D=3D27 || event.keyCode=3D= =3D32 || event.type=3D=3D"click" ) ) window.close( self ); CatchNumKeys( self, event ); } function Unload() { gIsEndShow=3D0; } function SetupEndShow() { gIsEndShow=3D1; PPTSld.document.body.scroll=3D"no"; PPTSld.document.onkeypress=3DCloseWindow; PPTSld.document.onclick=3DCloseWindow; PPTSld.document.oncontextmenu=3D_CM; } function EndShow() { if( IsFramesMode() ) return if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue doc=3DPPTSld.document var dir =3D doc.body.dir if( dir !=3D "rtl" ) dir =3D "ltr"; doc.open() doc.writeln('


' + ENDSHOW_MESG + '

') doc.close() } function SetSldVisited(){ GetSldList().mList[gCurSld-1].mVisited=3Dtrue } function IsSldVisited(){ return GetSldList().mList[gCurSld-1].mVisited } function hrefList( sldHref, visible, advDelay, advClk ) { this.mSldHref=3D this.mNtsHref =3D sldHref this.mOrigVis=3D this.mVis =3D visible this.mVisited=3D false this.mAdvDelay=3D advDelay this.mAdvOnClk=3D advClk } function SldList(arr,curSld,fEnd) { this.mCurSld =3D curSld; this.mList =3D new Array(); var idx =3D 1; for(ii=3D0;ii 0) { PushSldList(sldList,fEnd); gCurSld =3D 1; } else if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue } function PushSldList(arr,fEnd) { var ii =3D gSldStack.length; gSldStack[ii] =3D new SldList(arr,gCurSld,fEnd); GoToSld( gSldStack[ii].mList[0].mSldHref ); } function PopSldList() { if (gSldStack[gSldStack.length-1].fEndShow) EndShow() else { gCurSld =3D gSldStack[gSldStack.length-1].mCurSld; gSldStack[gSldStack.length-1] =3D null; gSldStack.length--; var sldList =3D gSldStack[gSldStack.length-1]; GoToSld( sldList.mList[gCurSld - 1].mSldHref ); } } var custShowList=3Dnew Array(); /********************************************* Navigation button implementation There are 2 types of buttons: ImgBtn, TxtBtn implemented as function objects. They share a similiar interface so the event handlers can call SetActive, for example, on a button=20 object without needing to know exactly=20 what type of button it is. **********************************************/ //---------------------------------- function ImgBtn( oId,bId,w,action ) //---------------------------------- { var t=3Dthis t.Perform =3D _IBP t.SetActive =3D _IBSetA t.SetInactive=3D _IBSetI t.SetPressed =3D _IBSetP t.SetDisabled=3D _IBSetD t.Enabled =3D _IBSetE t.ChangeIcon =3D null t.UserAction =3D action t.ChgState =3D _IBUI t.mObjId =3D oId t.mBorderId=3D bId t.mWidth =3D w t.mIsOn =3D t.mCurState =3D 0 } function _IBSetA() { if( this.mIsOn ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _IBSetI() { if( this.mIsOn ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0=20 } } function _IBSetP() { if( this.mIsOn ) { obj=3Dthis.ChgState( gShadowClr,gHiliteClr,2 ) obj.style.posLeft+=3D1; obj.style.posTop+=3D1 } } function _IBSetD() { =20 obj=3Dthis.ChgState( gFaceClr,gFaceClr,0 ) obj.style.posTop=3D0=20 } function _IBSetE( state ) { var t=3Dthis GetObj( t.mBorderId ).style.visibility=3D"visible" if( state !=3D t.mIsOn ) { t.mIsOn=3Dstate if( state ) t.SetInactive() else t.SetDisabled() } } function _IBP() { var t=3Dthis if( t.mIsOn ) { if( t.UserAction !=3D null ) t.UserAction() if( t.ChangeIcon ) { obj=3DGetObj(t.mObjId) if( t.ChangeIcon() ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-4)*t.mWidth else obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-0)*t.mWidth } t.SetActive() } =20 } function _IBUI( clr1,clr2,nextState ) { var t=3Dthis SetBorder( GetObj( t.mBorderId ),clr1,clr2 ) obj=3DGetObj( t.mObjId ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-nextState)*t.mWidth-obj= .style.posTop t.mCurState=3DnextState return obj } //----------------------------------------- function TxtBtn( oId,oeId,action,chkState ) //----------------------------------------- { var t=3Dthis t.Perform =3D _TBP t.SetActive =3D _TBSetA t.SetInactive=3D _TBSetI t.SetPressed =3D _TBSetP t.SetDisabled=3D _TBSetD t.SetEnabled =3D _TBSetE t.GetState =3D chkState t.UserAction =3D action t.ChgState =3D _TBUI t.mObjId =3D oId t.m_elementsId=3D oeId t.mIsOn =3D 1 } function _TBSetA() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gHiliteClr,gShadowClr,0,0 ) } function _TBSetI() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) } function _TBSetP() { if( this.mIsOn ) this.ChgState( gShadowClr,gHiliteClr,1,1 ) } function _TBSetD() { =20 this.ChgState( gFaceClr,gFaceClr,0,0 ) this.mIsOn =3D 0 } function _TBSetE() { var t=3Dthis if( !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) else t.ChgState( gShadowClr,gHiliteClr,1,1 ) t.mIsOn =3D 1 } function _TBP() { var t=3Dthis if( t.mIsOn ) {=20 if( t.UserAction !=3D null ) t.UserAction() if( !t.GetState ) return if( t.GetState() ) t.SetPressed() else t.SetActive() } =20 } function _TBUI( clr1,clr2,lOffset,tOffset ) { SetBorder( GetObj( this.mObjId ),clr1,clr2 ) Offset( GetObj( this.m_elementsId ),lOffset,tOffset ) } function Offset( obj, top, left ){ obj.style.top=3Dtop; obj.style.left=3Dle= ft } function SetBorder( obj, upperLeft, lowerRight ) { s=3Dobj.style; s.borderStyle =3D "solid" s.borderWidth =3D 1=20 s.borderLeftColor =3D s.borderTopColor =3D upperLeft s.borderBottomColor=3D s.borderRightColor =3D lowerRight } function GetBtnObj(){ return gBtnArr[window.event.srcElement.id] } function BtnOnOver(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetActive() } function BtnOnDown(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetPressed() } function BtnOnOut(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetInactive() } function BtnOnUp() { b=3DGetBtnObj() if( b !=3D null ) b.Perform() else Upd() } function GetNtsState(){ return parent.gNtsOpen } function GetOtlState(){ return parent.gOtlOpen } function GetOtlTxtState(){ return parent.gOtlTxtExp } function NtsBtnSetFlag( fVal ) { s=3Ddocument.all.item( this.m_flagId ).style s.display=3D"none" if( fVal ) s.display=3D"" else s.display=3D"none" } function _BSetA_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etActive() } function _BSetI_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etInactive() } function _BSetP_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etPressed() } function _BSetA_BorderImg() {=20 b =3D gBtnArr[this.mBorderId]=20 if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _BSetI_BorderImg() {=20 b =3D gBtnArr[this.mBorderId] if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0 } } var gHiliteClr=3D"THREEDHIGHLIGHT",gShadowClr=3D"THREEDSHADOW",gFaceClr=3D"= THREEDFACE" var gBtnArr =3D new Array() gBtnArr["nb_otl"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOtlPan= e,GetOtlState ) gBtnArr["nb_otlElem"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOt= lPane,GetOtlState ) gBtnArr["nb_nts"] =3D new ImgBtn( "nb_nts","nb_ntsBorder",10,parent.ToggleN= tsPane ) gBtnArr["nb_nts"].SetActive =3D _BSetA_BorderImg; gBtnArr["nb_nts"].SetInactive =3D _BSetI_BorderImg; gBtnArr["nb_ntsBorder"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.= ToggleNtsPane,GetNtsState ) gBtnArr["nb_ntsElem"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.To= ggleNtsPane,GetNtsState ) gBtnArr["nb_prevBorder"] =3D gBtnArr["nb_prev"]=3D new ImgBtn( "nb_prev","n= b_prevBorder",30,parent.GoToPrevSld ) gBtnArr["nb_nextBorder"] =3D gBtnArr["nb_next"]=3D new ImgBtn( "nb_next","n= b_nextBorder",30,parent.GoToNextSld ) gBtnArr["nb_sldshw"]=3D new ImgBtn( "nb_sldshw","nb_sldshwBorder",18,parent= .FullScreen ) gBtnArr["nb_sldshwBorder"] =3D new TxtBtn( "nb_sldshw","nb_sldshwBorder",pa= rent.FullScreen,null ) gBtnArr["nb_sldshwBorder"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwBorder"].SetInactive =3D _BSetI_Border; gBtnArr["nb_sldshwText"] =3D new TxtBtn( "nb_sldshw","nb_sldshwText",parent= .FullScreen,null ) gBtnArr["nb_sldshwText"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwText"].SetInactive =3D _BSetI_Border; gBtnArr["nb_voice"] =3D gBtnArr["nb_voiceBorder"] =3D new ImgBtn( "nb_voice= ","nb_voiceBorder",18,parent.ToggleVNarration ) gBtnArr["nb_otlTxtBorder"] =3D gBtnArr["nb_otlTxt"]=3D new ImgBtn( "nb_otlT= xt","nb_otlTxtBorder",23,parent.ToggleOtlText ) gBtnArr["nb_ntsBorder"].m_flagId=3D "nb_nts" gBtnArr["nb_ntsBorder"].SetFlag =3D NtsBtnSetFlag gBtnArr["nb_otlTxt"].ChangeIcon=3D GetOtlTxtState /********************************************* Context menu implementation _CM() is the function that's hooked up to the oncontextmenu event. Once we're asked to show the menu, we first build it by creating DIVs on-the-fly. Then we position it=20 within the screen area so it doesn't get clipped. Creating the DIVs using createElement() means we don't have to write out any extra HTML into the slide HTML files. **********************************************/ var sNext=3D"Siguiente",sPrev=3D"Anterior",sEnd=3D"Fin de la presentaci&oac= ute;n",sFont=3D"Arial",sArrow=3D"Flecha",sFreeform=3D"Forma libre",sRect=3D= "Rectángulo",sOval=3D"Óvalo" function ShowMenu() { BuildMenu(); var doc=3DPPTSld.document.body,x=3DPPTSld.event.clientX+doc.scrollLeft,y= =3DPPTSld.event.clientY+doc.scrollTop m =3D PPTSld.document.all.item("ctxtmenu") m.style.pixelLeft=3Dx if( (x+m.scrollWidth > doc.clientWidth)&&(x-m.scrollWidth > 0) ) m.style.pixelLeft=3Dx-m.scrollWidth m.style.pixelTop=3Dy if( (y+m.scrollHeight > doc.clientHeight)&&(y-m.scrollHeight > 0) ) m.style.pixelTop=3Dy-m.scrollHeight m.style.display=3D"" } function _CM() { if( !parent.IsFullScrMode() ) return; if(!PPTSld.event.ctrlKey) { ShowMenu() return false } else HideMenu() } function BuildMenu() { if( PPTSld.document.all.item("ctxtmenu") ) return var mObj=3DCreateItem( PPTSld.document.body ) mObj.id=3D"ctxtmenu" mObj.style.visibility=3D"hidden" var s=3DmObj.style s.position=3D"absolute" s.cursor=3D"default" s.width=3D"120px" SetCMBorder(mObj,"menu","black") var iObj=3DCreateItem( mObj ) SetCMBorder( iObj, "threedhighlight","threedshadow" ) iObj.style.padding=3D2 CreateMenuItem( iObj,sNext,M_GoNextSld,M_True ) CreateMenuItem( iObj,sPrev,M_GoPrevSld,M_HasPrevSld ) =09 CreateSeparator( iObj ) CreateMenuItem( iObj,sEnd,M_End,M_True ) mObj.style.visibility=3D"visible" } function Cancel() { window.event.cancelBubble=3Dtrue; window.event.returnVa= lue=3Dfalse } function Highlight() { ChangeClr("activecaption","threedhighlight") } function Deselect() { ChangeClr("threedface","menutext") } function Perform() { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) e.Action() else PPTSld.event.cancelBubble=3Dtrue } function ChangeClr( bg,clr ) { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) { e.style.backgroundColor=3Dbg e.style.color=3Dclr } } function M_HasPrevSld() { return( parent.HasPrevSld() ) } function M_GoNextSld() { if( gIsEndShow ) M_End(); else GoToNextSld() } function M_GoPrevSld() { if( gIsEndShow ) { gIsEndShow=3D0; history.back();= PPTSld.event.cancelBubble=3Dtrue; } else GoToPrevSld() } function M_True() { return true } function M_End() { window.close( self ) } function CreateMenuItem( node,text,action,eval ) { var e=3DCreateItem( node ) e.type=3D"menuitem" e.Action=3Daction e.IsActive=3Deval e.innerHTML=3Dtext if( !e.IsActive() ) e.style.color=3D"threedshadow" e.onclick=3DPerform e.onmouseover=3DHighlight e.onmouseout=3DDeselect s=3De.style; 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charset="us-ascii" Trombosis. Fármacos Antitrombóticos. ------=_NextPart_01C7842C.6DCF0620 Content-Location: file:///C:/E31BBA37/sangre2-2006-07_archivos/outline.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii"
 No= tas
Presentac= ión
Esquema
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