MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01C7842B.A1942810" Este documento es una página Web de un solo archivo, también conocido como archivo de almacenamiento Web. Si está viendo este mensaje, su explorador o editor no admite archivos de almacenamiento Web. Descargue un explorador que admita este tipo de archivos, como Microsoft Internet Explorer. ------=_NextPart_01C7842B.A1942810 Content-Location: file:///C:/E31BBA37/sangre1-2006-07.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Hemostasia. Farmacos Antihemorrágicos

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=
=
=
OBJETIVOS DEL TEMA
1.-= según = su mecanismo de accion.=
2.- Valorar el p= apel de la Vitamina K en caso de <= span style=3D'position:absolute;top:56.95%;left:4.02%;width:90.99%;height:4.5%'= >.
3.- Valorar la eficacia de los diferentes tipos de Heparinas.
4.- Describir la farmacocinetica de la Heparina.
FARMACOLOGIA DE LA SANGRE
HEMOST= ASIA, HEMORRAGIA, TROMBOSIS
3D"VOLVER
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•C= ONCEPTO: MECANISMOS DE HEMOSTASIA &= #13;
•<= b>CONTROLABLES FARMACOLOGICAMENTE:
•1= . AGREGACION PLAQUETARIA:
•<= span style=3D'mso-spacerun:yes'>   - TROMBO PLAQUETARIO. <= /span>
•<= span style=3D'mso-spacerun:yes'>   - HEMORRAGIA POR DEFICIT DE PLAQ.:
•<= span style=3D'mso-spacerun:yes'>     CONCENTRADOS DE PLAQUETAS.
•<= span style=3D'mso-spacerun:yes'>   - TROMBOSIS ARTERIAL (TROMBO
•<= span style=3D'mso-spacerun:yes'>      BLANCO): = ANTIAGREGANTES PLAQ.
•2= . COAGULACION SANGUINEA= :
•<= span style=3D'mso-spacerun:yes'>   - TAPON HEMOSTATICO.
•<= span style=3D'mso-spacerun:yes'>   - HEMORRAGIA POR DEFICIT DE FACT.
•<= span style=3D'mso-spacerun:yes'>     DE LA COAGULACI= ON: CONCENTRADOS
•     DE FACTORES COA= GUL. O FARMACOS
•     PROCOAGULANTES.=
•<= span style=3D'mso-spacerun:yes'>   - TROMBOSIS VENOSA (TROMBO ROJO):
•<= span style=3D'mso-spacerun:yes'>     FARMACOS ANTICOAGULANTES.
•3= . FIBRINOLISIS: DISOLUCION DEL TROMBO =
•<= span style=3D'mso-spacerun:yes'>        = ;   - HEMORRAGIA POR EXCESO:
•<= span style=3D'mso-spacerun:yes'>        = ;      FARMACOS ANTIFIBRINOLITICOS.
•        = ;   - TROMBOSIS POR DEFECTO:
•<= span style=3D'mso-spacerun:yes'>        = ;      FARMACOS FIBRINOLIT= ICOS.
=
FARMACOLOGIA DE LA SA= NGRE
 HEMOSTASIA, HEMORRAGIA, TROMBOSIS
<= area href=3D"http://www.ugr.es/~rsaucedo/temas/temas.htm" target=3D"_parent" onclick=3D"window.event.cancelBubble=3Dtrue;" shape=3Drect coords=3D"0, 0, 41, 40">3D"VOLVER
Hemostasia:

La Hemostasia en sentido amplio, es el conjunto de mecanismos fisiológicos que se encargan, tanto de impedir la salida de la san= gre al exterior de los vasos sanguíneos, fenómeno que conocemos= con el nombre de Hemorragia, como de impedir el desarrollo indefinido de trom= bos en el interior de los vasos, fenómeno que conocemos con el nombre = de Trombosis.

Las alteraciones patológicas de cualquiera de dichos mecanismos de la Hemostasia, tanto en el sentido de potenciarlos como de inhibirlos, darán lugar a fenómenos hemorrágicos o trombóticos que podremos controlar farmacológicamente.
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•1= . F. ANTIHEMORRAGICOS:
•-= F. PROCOAGULANTES.
•-= F. ANTIFIBRINOLITICOS.
•2= . F. ANTITROMBOTICOS= :
•-= F. ANTICOAGULANTES(TROMBOSTATICOS)
•-= F. FIBRINOLITICOS(TROMBOLITICOS)
•-= F. ANTIAGREGANTES PLAQUETARIOS
FARMACOLOGIA DE LA SANGRE
 FARMACOS. CLASIFICACION&= #13;
<= area href=3D"http://www.ugr.es/~rsaucedo/temas/temas.htm" target=3D"_parent" onclick=3D"window.event.cancelBubble=3Dtrue;" shape=3Drect coords=3D"0, 0, 41, 40">3D"VOLVER
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=
FARMACOS A= NTIHEMORRAGICOS
PROCOA= GULANTES
•VITAM= INA K:
•T= IPOS:  - K1 (FITOMENADIONA).
•<= span style=3D'mso-spacerun:yes'>       - K3 (MENADIONA).
•<= span style=3D'mso-tab-count:1;width:14.32%'>     - K4 (MENADIOL).
•V= IAS DE ADMINISTRACION:
•-= VIA ORAL:
•  + SON VITAMINAS LIPOSOLUBLES.
•<= span style=3D'mso-spacerun:yes'>  + NECESARIAS PARA SU ABSORCION= 3;
•<= span style=3D'mso-spacerun:yes'>     BILIS Y LIPASA PANCREATICA.
•-= VIA PARENTERAL: i.m. e i.v.
•A= CCIONES FARMACOLOGICAS:
•- INDISPENSABLE PARA LA SINTESIS
•<= span style=3D'mso-spacerun:yes'>  HEPATICA DE LOS  FACTORES II,VII,I= X,X.
•- EFECTO RETARDADO (12 HORAS).
•-= ES EL ANTIDOTO EN CASO DE INTOXICA-
•<= span style=3D'mso-spacerun:yes'>  CION POR ANTICOAGULANTES ORALES.&= #13;
•-= ANEMIA HEMOLITICA DEFICIT G-6-PDH.
3D"VOLVER
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•V= ITAMINA K:
•
•<= b>FACTOR COAG.        = ;         FACTOR CO= AG.
•<= b>NO EFICAZ        = ;            &n= bsp;     EFICAZ= 3;
•
•A= .GLUTAMICO        = ;      A.G.CARBOXILADO
•<= span style=3D'mso-spacerun:yes'>        = ;            &n= bsp;            = ;            &n= bsp;            SANGRE
•
•
•V= IT. K        = ;            &n= bsp;            = ;      VIT. K
•(= HIDROQUINONA)        = ;         (EPOXIDO)
•
•
•V= IT. K        = ;            &n= bsp;            = ;             VIT. K
•R= EDUCTASA       VIT. K        = ;    REDUCTASA
•<= span style=3D'mso-spacerun:yes'>        = ;            &n= bsp;    (QUINONA)
•
•<= span style=3D'mso-spacerun:yes'>        = ;            &n= bsp;          HIGADO
•<= span style=3D'mso-spacerun:yes'>        = ;            &n= bsp;     
=
FARMACOS P= ROCOAGULANTES
MECANI= SMO DE ACCION
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•S. HEMORRAGICOS CON FIBRINOLISIS
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Farmacos Antihemorrágicos
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FARMACOS ANTIFIBRINOLITICOS
MECANI= SMO DE ACCION
<= span style=3D'font-family:Arial;color:#0012FF'>FACTORES
COAGULACION
PLASMINOGENO
PLASMINA
FIBRINA
FIBRINOLISIS
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FARMACOS
ANTIFIBRINOLITICOS:

ANTAGONISTAS COMPETITI-
VOS DE LOS ACTIVADORES
FISIOLOGICOS DEL PLASMI-
NOGENO.
INHIBIDORES
NATURALES
SE FORMA EL COMPLEJO:
ANTIFIBRINOLITICO-PLASMINOGENO
A DOSIS ALTAS: INHIBIDORES DE PLASMINA
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ACTIVADOR
TISULAR
ENDOTELIO
SISTEMA FIBRINOLITICO:
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R0lGODlhKQApAHcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAAAAQAo ACgAggAAAJkAAM0AAP8AAP8yMv9mZgECAwECAwPNWLTc/jCyoqS9L9CKewza5o0NGIqkZ55oaq1s 62bwZhdDru98v8Og28ZHLA6AsaFxqUMKKcyo8xllToXVXIB4vWVNvq6tCuuJlUsk7wxtgtdveI3q BpnjP+ATV9/K/X8me3l2f2F6dFp4ioWBQYlHi5GNhCuDlYZ3c1iVgGWalpCTSJSdj5ymn6CCooxA RWx8XKWHm15ZsIiouKunt7y9SW3AjsKyxH2sNwLMzc7P0NC6G9HV1s+2Bdfb16EU3ODVyuHk0iHl 6M4a6ezMCQA7 ------=_NextPart_01C7842B.A1942810 Content-Location: file:///C:/E31BBA37/sangre1-2006-07_archivos/slide0018.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Hemostasia. Farmacos Antihemorrágicos
•- CLASIFICACION:
•<= span style=3D'mso-spacerun:yes'>   + HEPARINA  NO FRACCIONADA (HNF) .
•<= span style=3D'mso-spacerun:yes'>   + HEPARINAS BAJO PESO MOLECULAR
•      (HBPM):       * ENOXAPARINA.
•        = ;            &n= bsp;      * DALTEPARINA.
FARMACOS ANTITROMBOTICOS<= br>  ANTICOAGULANTES
•- CONCEPTO.
=
•   + ANTICOAGULANTES = ORALES.
•H= EPARINA:
•+ SE EXTRAE DE TEJIDOS ANIMALES.
•+ POLISACARIDO RICO EN RADICALES SO4
•+ CARACTER FUERTEMENTE ACIDO.
<= area href=3D"http://www.ugr.es/~rsaucedo/temas/temas.htm" target=3D"_parent" onclick=3D"window.event.cancelBubble=3Dtrue;" shape=3Drect coords=3D"0, 0, 41, 40">3D"VOLVER
Fármacos antitromboticos: Son aquellos que impiden el desarrollo indefinido de tro= mbos en el interior de los vasos y/o promueven su desaparición.<= br>

Farmacos anticoagulantes son aquellos que previenen la formacion de fibrina patológica o impiden que se siga formando.
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PLAQUETAS
AGREGADAS
* ANTITROMBINA III
“IN VITRO”
FACTOR HISTICO
“TF”
VII
XII      XIIa<= /span>
XI       XIa=
IX       IXa=         = ;  Ca++
VIII       VIIIa         PF3
X         Xa        Ca++
V        = ;  Va         PF3
TROMBINA
II
XIIIa      XIII<= /span>
FIBRINA I       FS<= span style=3D'mso-spacerun:yes'>      FIBRINOGE= NO
*
*
*
*
*
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PROTROMBINASA
Ca++        “IN VIVO”
TF-VIIa
*
COAGULACION SANGUINEA
Fisiologicamente la molecula encargada de frenar la coagulación es la Anti-trombina= -III que  representa el 90% de la actividad total anticoagulante, siendo el 10% restante para el Cofactor I= I de la heparina y otras moleculas de la sangre. La ATIII inactiva los factore= s de la coagulación que se van formando en cantidades fisológicas incluida la trombina. Si el estímulo patológico es mayor, la ATIII se vé superada y se forman cantidades de factor Xa que gener= an trombina que a su vez genera cantidades patologicas de fibrina y por tanto favorece el desarrollo del trombo. En este momento es cuando el uso de ciertos anticoagulantes han de ser usados en clínica.
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Farmacos Antihemorrágicos
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Farmacos Antihemorrágicos
<= /v:shape>
•ACCION ANTICOAGULANTE:=
• (TROMBOSTATICA)
• - DISMINUYE LA CAPAC= IDAD DE LA
•   SANGRE PARA COAGULAR.
• - TANTO “IN VIVO” COMO “IN VITRO”. =
• - COMPLEJO HEPARINA-ANTITROMBINA III:
•   1º.- EFECTO ANTITROMBINICO DIRECTO:
•      &n= bsp; INACTIVACION FACTOR IIa (TROMBINA).<= /div>
= =
FARMACOS ANTICOAGULANTES
HEPARINA: ACCIONES FARMACOLOGICAS
•  2º.- EFECTO ANTITROMBINICO INDIRECTO:
•    + INACTIVACI= ON FACTORES:
•        = ;            &n= bsp;    VIIa, IXa, Xa, XIa, XIIa
•    + FACTOR Xa MUY SENSIBLE HEPARINA
•       DOSIS BAJAS. (PROFILAXIS)
<= area href=3D"http://www.ugr.es/~rsaucedo/temas/temas.htm" target=3D"_parent" onclick=3D"window.event.cancelBubble=3Dtrue;" shape=3Drect coords=3D"0, 0, 41, 40">3D"VOLVER
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F= ARMACOS ANTICOAGULANTES
HEPARINA. FARMACOCINETICA
•A= BSORCION:
•- VIA ORAL Y SUBLINGUAL:
•    + INEFICAZ.<= span style=3D'mso-spacerun:yes'>  FUERTE POLARIDAD.
•    + PASA MAL MEMBRANAS.
•- VIA I.M. : HEMATOMAS LOCALES.
•- VIA S.C. PROFUNDA: HEPARINA CALCICA
•- VIA I.V. (BOLO, INFUSION CONTINUA):
•        = ;            &n= bsp;   HEPARINA SODICA= .
•E= XCRECION:
•- HEPARINASA HEPATICA.  S.R.E.
•- PARCIALMENTE SIN ALTERAR EN ORINA
•- LA VIDA MEDIA ES DOSIS-DEPENDIENTE
•      (MINUTOS-5 HORAS) (HNF) .
- IMPOSIBLE DOSIFICAR EN FUNCION DE =
  DICHO PARAMETRO.
•- ALARGADA EN INSUF. HEPATICA O
•      = RENAL TERMINAL.
3D"VOLVER
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=
=
=
RESUMEN:
1.- LA VITAMINA K ES DE EFECTO <= /b>RETARDADO SEA CUAL SEA LA VIA= DE ADMINIATRACION .
2.- LOS ANTIFIBRINOLITICOS <= /span>PREDISPONEN A LA TROMBOSIS.&#= 13;
3.- LA HEPARINA TIENE UNA MAYOR = ACTIVIDAD INTRINSECA QUE LAS = HEPARINAS FRACCIONADAS. <= /b>
4.- LA HEPARINA TIENE UNA CINETI= CA COMPLEJA QUE EXPLICA SU <= /span>COMPORTAMIENTO CLINICO. <= /b>
FARMACOLOGIA DE LA SANGRE
HEMORRAGIA Y TROMBOS= IS
3D"VOLVER
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BIBLIOGRAFIA:
1.- J.Flóre= z
Farmacologia Humana
4ª Edicion 2003.
FARMACOLOGIA DE LA SANGRE
HEMORRAGIA Y TROMBOS= IS
3D"VOLVER
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Hemostasia:
La Hemostasia en sentido amplio, es el conjunto de mecanismos fisiológicos que se encargan, tanto de impedir la salida= de la sangre al exterior de los vasos sanguíneos, fenómeno que conocemos con el nombre de Hemorragia, como de impedir el desarrollo indefinido de trombos en el interior de los = vasos, fenómeno que conocemos con el nombre de Trombosis.
Las alteraciones patológicas de cualqui= era de dichos mecanismos de la Hemostasia, tanto en el sentido de potenciarlos co= mo de inhibirlos, darán lugar a fenómenos hemorrágicos o trombóticos que podremos controlar farmacológicamente.
Fármacos antitromboticos: = Son aquellos que impiden el desarrollo indefinido de trombos en el interior de= los vasos y/o promueven su desaparición.
Farmacos anticoagulantes son aquellos que previenen la formacion de fibrin= a patológica o impiden que se siga formando.
Fisiologicamente la molecula enca= rgada de frenar la coagulación es la Anti-trombina-III que  representa el 90% de la actividad= total anticoagulante, siendo el 10% restante para el Cofactor II de la heparina y otras moleculas de la sangre. La ATIII inactiva los factores de la coagulación que se van formando en cantidades fisológicas incluida la trombina. Si el estímulo patológico es mayor, la ATIII se vé superada y se forman cantidades de factor Xa que generan trombina que a su vez genera cantidades patologicas de fibrina y por tanto favorece el desarrollo del trombo. En este momento es cuando el uso de cie= rtos anticoagulantes han de ser usados en clínica.
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------=_NextPart_01C7842B.A1942810 Content-Location: file:///C:/E31BBA37/sangre1-2006-07_archivos/script.js Content-Transfer-Encoding: quoted-printable Content-Type: application/javascript; charset="us-ascii" function LoadSld() { var sld=3DGetObj("SlideObj") if( !g_supportsPPTHTML ) { =09 sld.style.visibility=3D"visible" return } if( MakeNotesVis() ) return runAnimations =3D _InitAnimations(); =09 if( IsWin("PPTSld") ) parent.SldUpdated(GetSldId()) g_origSz=3DparseInt(SlideObj.style.fontSize) g_origH=3Dsld.style.posHeight g_origW=3Dsld.style.posWidth g_scaleHyperlinks=3D(document.all.tags("AREA").length>0) if( g_scaleHyperlinks ) InitHLinkArray() if( g_scaleInFrame||(IsWin("PPTSld") && parent.IsFullScrMode() ) ) document.body.scroll=3D"no" _RSW() if( IsWin("PPTSld") && parent.IsFullScrMode() ) FullScrInit(); =09 MakeSldVis(); ChkAutoAdv() if( runAnimations ) { if( document.all("NSPlay") ) document.all("NSPlay").autoStart =3D false; if( sld.filters && sld.filters.revealtrans ) setTimeout( "document.body.start()", sld.filters.revealtrans.duration * = 1000 ); else document.body.start(); } } function MakeSldVis()=20 { var fTrans=3Dg_showAnimation && SldHasTrans() if( fTrans )=09 { if( g_bgSound ) { idx=3Dg_bgSound.indexOf(","); pptSound.src=3Dg_bgSound.substr( 0, idx ); pptSound.loop=3D -(parseInt(g_bgSound.substr(idx+1))); } SlideObj.filters.revealtrans.Apply()=09 } SlideObj.style.visibility=3D"visible" if( fTrans ) SlideObj.filters.revealtrans.Play() } function MakeNotesVis()=20 { if( !IsNts() ) return false=20 SlideObj.style.display=3D"none" nObj =3D document.all.item("NotesObj") parent.SetHasNts(0) if( nObj ) {=20 nObj.style.display=3D"" parent.SetHasNts(1) } return 1 } function ChkAutoAdv() { if(SldHasTrans()) SlideObj.onfilterchange=3DAutoAdv else AutoAdv() } function AutoAdv() { if(!IsWin("PPTSld") || !gUseSldTimings )return var sld=3DGetCurSld() if( (sld.mAdvDelay>0) && !parent.IsFramesMode() ) setTimeout("parent.GoToNextSld()",sld.mAdvDelay) } function GetObj(id) { if(g_supportsPPTHTML) return document.all(id); else return document.getElementById(id); } function SldHasTrans() { return SlideObj.style.filter !=3D ""; } function GetSldId() { return sId=3Dlocation.href.substring(location.href.la= stIndexOf('/')+1) } function HideMenu() { if( frames["PPTSld"] && PPTSld.document.all.item("ctx= tmenu") && PPTSld.ctxtmenu.style.display!=3D"none" ) { PPTSld.ctxtmenu.styl= e.display=3D'none'; return true } return false } function IsWin( name ) { return window.name =3D=3D name } function IsNts() { return IsWin("PPTNts") } function IsSldOrNts() { return( IsWin("PPTSld")||IsWin("PPTNts") ) } function SupportsPPTAnimation() { return( navigator.platform =3D=3D "Win32"= && navigator.appVersion.indexOf("Windows")>0 ) } function SupportsPPTHTML() { var appVer=3Dnavigator.appVersion, msie=3DappVer.indexOf("MSIE "), ver=3D0 if( msie >=3D 0 ) ver=3DparseFloat( appVer.substring( msie+5, appVer.indexOf(";",msie) ) ) else ver=3DparseInt(appVer) return( ver >=3D 4 && msie >=3D 0 ) } function _RSW() { if( !g_supportsPPTHTML || IsNts() || ( !g_scaleInFrame && (!IsWin("PPTSld") || !parent.IsFullScrMode()) ) ) return var padding=3D0; if( IsWin("PPTSld") && parent.IsFramesMode() ) padding=3D6 cltWidth=3Ddocument.body.clientWidth-padding cltHeight=3Ddocument.body.clientHeight-padding factor=3D(1.0*cltWidth)/g_origW if( cltHeight < g_origH*factor ) factor=3D(1.0*cltHeight)/g_origH newSize =3D g_origSz * factor if( newSize < 1 ) newSize=3D1 s=3DSlideObj.style s.fontSize=3DnewSize+"px" s.posWidth=3Dg_origW*factor s.posHeight=3Dg_origH*factor s.posLeft=3D(cltWidth-s.posWidth+padding)/2 s.posTop=3D(cltHeight-s.posHeight+padding)/2 if( g_scaleHyperlinks ) ScaleHyperlinks( factor ) } function _InitAnimations() { animRuntimeInstalled =3D ''+document.body.localTime !=3D 'undefined'; isFullScreen =3D (window.name =3D=3D "PPTSld") && !parent.IsFramesMode(); g_animUseRuntime =3D g_showAnimation && animRuntimeInstalled && !(isFullSc= reen && parent.IsSldVisited()); if( g_animUseRuntime ) { collSeq =3D document.all.tags("seq"); if( collSeq !=3D null ) { for(ii=3D0;ii numSlds ) gSldJumpIdx =3D numSlds; if ( gSldJumpIdx >=3D 0 ) { if ( gSldJumpIdx =3D=3D 0 ) gSldJumpIdx =3D 1; var jumpTo =3D parseInt(gSldJumpIdx); gSldJump =3D 0; gSldJumpIdx =3D ""; win.GoToSld( parent.GetSldList().mList[jumpTo-1].mSldHref ) } } } function _KDH() { if( event.keyCode =3D=3D 8 ) { event.returnValue =3D 0; parent.GoToPrevSld(); } } var g_HLinkArray =3D new Array(); =20 function IMapAreaObj( areaObj, coords ) { this.areaObj =3D areaObj; this.coords =3D coords; } function InitHLinkArray() { var appVer =3D navigator.appVersion; var msie =3D appVer.indexOf ( "MSIE " ) var ver =3D 0; if ( msie >=3D 0 ) ver =3D parseInt ( appVer.substring( msie+5 ) ); linkNum =3D 0; for (i=3D0; i 4 ) ) g_HLinkArray[linkNum++] =3D new IMapAreaObj( areaObj, ParseCoords( ar= eaObj.coords ) ); } } function ScaleHyperlinks( factor ) { =20 for ( ii=3D0; ii< g_HLinkArray.length; ii++) { coordsStr=3D""; imaObj =3D g_HLinkArray[ii]; for ( jj=3D0; jj < imaObj.coords.length-1; jj++ ) coordsStr +=3D (imaObj.coords[jj]*factor) + ","; coordsStr +=3D (imaObj.coords[jj]*factor); imaObj.areaObj.coords =3D coordsStr; } } function ParseCoords( coordsStr ) { var numArray =3D new Array(); var i =3D curPos =3D commaPos =3D 0; while ( ( commaPos =3D coordsStr.indexOf(",", curPos) ) !=3D -1 ) {=20 numArray[i++] =3D parseInt( coordsStr.substr( curPos, commaPos ) ); curPos =3D commaPos + 1; } numArray[i] =3D parseInt( coordsStr.substr( curPos ) ); return numArray; } function DocumentOnClick() { if( IsNts() || parent.HideMenu() ) return; if( ( g_allowAdvOnClick && (window.name=3D=3D"PPTSld") && !parent.IsFrames= Mode() ) || (event && event.keyCode=3D=3D32) ) { =09 if( g_animUseRuntime && g_animMainSequence && g_animMainSequence.cangonex= t ) return; parent.GoToNextSld(); } } var g_supportsPPTHTML =3D SupportsPPTHTML(), g_scaleInFrame =3D 1, gId=3D""= , g_bgSound=3D"", g_scaleHyperlinks =3D false, g_allowAdvOnClick =3D 1, g_showInBrowser = =3D 1, gLoopCont =3D 0, gUseSldTimings =3D 0; var g_showAnimation =3D g_supportsPPTHTML && SupportsPPTAnimation() && ( (w= indow.name=3D=3D"PPTSld" && !parent.IsFramesMode()) || g_showInBrowser );va= r g_animManager =3D null; var g_animUseRuntime =3D false; var g_animItemsToHide, g_animInteractiveItems, g_animSlideTime; var g_animMainSequence =3D null; var ENDSHOW_MESG=3D"Fin de la presentación, haga clic para salir.", = SCREEN_MODE=3D"Frames", gIsEndShow=3D0, NUM_VIS_SLDS=3D14, SCRIPT_HREF=3D"s= cript.js", FULLSCR_HREF=3D"fullscreen.htm"; var gCurSld =3D gPrevSld =3D 1, g_offset =3D 0, gNtsOpen =3D gHasNts =3D gO= tlTxtExp =3D 0, gHasNarration =3D 0, gOtlOpen =3D true window.gPPTHTML=3DSupportsPPTHTML() var gMainDoc=3Dnew Array(new hrefList("slide0042.htm",1,-1,1),new hrefList(= "slide0001.htm",1,-1,1),new hrefList("slide0045.htm",1,-1,1),new hrefList("= slide0010.htm",1,-1,1),new hrefList("slide0017.htm",1,-1,1),new hrefList("s= lide0011.htm",1,-1,1),new hrefList("slide0014.htm",1,-1,1),new hrefList("sl= ide0018.htm",1,-1,1),new hrefList("slide0021.htm",1,-1,1),new hrefList("sli= de0039.htm",1,-1,1),new hrefList("slide0019.htm",1,-1,1),new hrefList("slid= e0025.htm",1,-1,1),new hrefList("slide0043.htm",1,-1,1),new hrefList("slide= 0044.htm",1,-1,1)); /********************************************* Frameset functions These functions control slide navigation and state of the frameset. **********************************************/ function FullScrInit() { g_allowAdvOnClick =3D GetCurSld().mAdvOnClk document.body.style.backgroundColor=3D"black" document.oncontextmenu=3Dparent._CM; document.onkeydown =3D _KDH; document.ondragstart=3DCancel document.onselectstart=3DCancel self.focus() } function Redirect( frmId ) {=09 var str=3Ddocument.location.hash,idx=3Dstr.indexOf('#'), sId=3DGetSldId() if(idx>=3D0) str=3Dstr.substr(1); if( window.name !=3D frmId && ( sId !=3D str) ) { obj =3D GetObj("Main-File") window.location.href=3Dobj.href+"#"+sId return 1 } return 0 } var MHTMLPrefix =3D CalculateMHTMLPrefix();=20 function CalculateMHTMLPrefix() { if ( document.location.protocol =3D=3D 'mhtml:') {=20 href=3Dnew String(document.location.href)=20 Start=3Dhref.indexOf('!')+1=20 End=3Dhref.lastIndexOf('/')+1=20 if (End < Start)=20 return href.substring(0, Start)=20 else=20 return href.substring(0, End)=20 } return ''; } function GetTags(base,tag) { if(g_supportsPPTHTML) return base.all.tags(tag); else return base.getElementsByTagName(tag); } function UpdNtsPane(){ if(frames["PPTNts"]) PPTNts.location.replace( MHTMLP= refix+GetHrefObj( gCurSld ).mNtsHref ) } function UpdNavPane( sldIndex ){ if(gNavLoaded) PPTNav.UpdNav() } function UpdOtNavPane(){ if(gOtlNavLoaded) PPTOtlNav.UpdOtlNav() } function UpdOtlPane(){ if(gOtlLoaded) PPTOtl.UpdOtl() } function SetHasNts( fVal ) { if( gHasNts !=3D fVal ) { gHasNts=3DfVal UpdNavPane() } } function ToggleOtlText() { gOtlTxtExp=3D!gOtlTxtExp UpdOtlPane() } function ClearMedia() { // Clear any sounds playing before launching another browser window. Other= wise, // in fullscreen mode, you'll continue to hear the sound in the frames mod= e. if (PPTSld.pptSound) PPTSld.pptSound.loop =3D 0; } function FullScreen() {=20 if ( PPTSld.g_animUseRuntime ) PPTSld.document.body.pause(); ClearMedia(); var href =3D ( document.location.protocol =3D=3D 'mhtml:') ? FULLSCR_HREF = : FULLSCR_HREF+"#"+GetHrefObj(gCurSld).mSldHref; if(PPTNav.event.ctrlKey) { var w =3D (window.screen.availWidth * 1.0) / 2.0 var h =3D w * (PPTSld.g_origH * 1.0) / PPTSld.g_origW win =3D window.open( MHTMLPrefix+href,null,"toolbar=3D0,resizable=3D1,top= =3D0,left=3D0," + "width=3D"+ w + ",height=3D" + h ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } else { win =3D window.open( MHTMLPrefix+href,null,"fullscreen=3Dyes" ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } } function ToggleVNarration() { rObj=3DPPTSld.document.all("NSPlay") if( rObj && !PPTSld.g_animUseRuntime ) { if( (rObj.playState =3D=3D 1)||(rObj.playState =3D=3D 0) ) rObj.Play() else if( rObj.playState =3D=3D 2 ) rObj.Pause() else return; } else if( PPTSld.g_animUseRuntime ) { narObj =3D PPTSld.document.all("narrationID") if( narObj ) narObj.togglePause() } } function GetCurSldNum() { =20 obj=3DGetHrefObj(gCurSld) if( obj.mOrigVis =3D=3D 1 ) return obj.mSldIdx else =20 return gCurSld } function GetNumSlds() { =20 if( GetHrefObj(gCurSld).mOrigVis =3D=3D 1 ) return GetSldList().mNumVisSlds; else return GetSldList().mList.length } function GetSldNum( href ) { for(ii=3D0; ii 1 ) PopSldList(); else if( !IsFramesMode() ) { if( gLoopCont ) GoToFirst() else EndShow() } } function GoToPrevSld() { ii=3DgCurSld-1 if( ii > 0 ) { obj=3DGetHrefObj(ii) while ( obj && ( obj.mVis =3D=3D 0 ) && ( ii>0 ) ) obj=3DGetHrefObj(--ii) if( ii =3D=3D 0 ) ii=3D1 GoToSldNum(ii) } } function GoToFirst(){ GoToSld( GetHrefObj(1).mSldHref ) } function GoToLast() { ii=3DGetSldList().mList.length if( ii !=3D gCurSld ) GoToSld( GetHrefObj(ii).mSldHref ) } function GoToSldNum( num ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue obj =3D GetHrefObj( num ) obj.mVis=3D1 gPrevSld=3DgCurSld gCurSld =3D num; PPTSld.location.replace(MHTMLPrefix+obj.mSldHref) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function GoToSld( href ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue GetHrefObj( GetSldNum(href) ).mVis=3D1 PPTSld.location.replace(MHTMLPrefix+href) } function SldUpdated( id ) { if( id =3D=3D GetHrefObj(gCurSld).mSldHref ) return gPrevSld=3DgCurSld gCurSld=3DGetSldNum(id) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function PrevSldViewed(){ GoToSld( GetHrefObj(gPrevSld).mSldHref ) } function HasPrevSld() { return ( gIsEndShow || ( gCurSld !=3D 1 && GetHrefO= bj( gCurSld-1 ).mVis =3D=3D 1 )||( GetCurSldNum() > 1 ) ) } function HasNextSld() { return (GetCurSldNum() !=3D GetNumSlds()) } function CloseWindow() { if( HideMenu() ) return; =09 var event =3D PPTSld.event; if( !IsFramesMode() && event && (event.keyCode=3D=3D27 || event.keyCode=3D= =3D32 || event.type=3D=3D"click" ) ) window.close( self ); CatchNumKeys( self, event ); } function Unload() { gIsEndShow=3D0; } function SetupEndShow() { gIsEndShow=3D1; PPTSld.document.body.scroll=3D"no"; PPTSld.document.onkeypress=3DCloseWindow; PPTSld.document.onclick=3DCloseWindow; PPTSld.document.oncontextmenu=3D_CM; } function EndShow() { if( IsFramesMode() ) return if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue doc=3DPPTSld.document var dir =3D doc.body.dir if( dir !=3D "rtl" ) dir =3D "ltr"; doc.open() doc.writeln('


' + ENDSHOW_MESG + '

') doc.close() } function SetSldVisited(){ GetSldList().mList[gCurSld-1].mVisited=3Dtrue } function IsSldVisited(){ return GetSldList().mList[gCurSld-1].mVisited } function hrefList( sldHref, visible, advDelay, advClk ) { this.mSldHref=3D this.mNtsHref =3D sldHref this.mOrigVis=3D this.mVis =3D visible this.mVisited=3D false this.mAdvDelay=3D advDelay this.mAdvOnClk=3D advClk } function SldList(arr,curSld,fEnd) { this.mCurSld =3D curSld; this.mList =3D new Array(); var idx =3D 1; for(ii=3D0;ii 0) { PushSldList(sldList,fEnd); gCurSld =3D 1; } else if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue } function PushSldList(arr,fEnd) { var ii =3D gSldStack.length; gSldStack[ii] =3D new SldList(arr,gCurSld,fEnd); GoToSld( gSldStack[ii].mList[0].mSldHref ); } function PopSldList() { if (gSldStack[gSldStack.length-1].fEndShow) EndShow() else { gCurSld =3D gSldStack[gSldStack.length-1].mCurSld; gSldStack[gSldStack.length-1] =3D null; gSldStack.length--; var sldList =3D gSldStack[gSldStack.length-1]; GoToSld( sldList.mList[gCurSld - 1].mSldHref ); } } var custShowList=3Dnew Array(); /********************************************* Navigation button implementation There are 2 types of buttons: ImgBtn, TxtBtn implemented as function objects. They share a similiar interface so the event handlers can call SetActive, for example, on a button=20 object without needing to know exactly=20 what type of button it is. **********************************************/ //---------------------------------- function ImgBtn( oId,bId,w,action ) //---------------------------------- { var t=3Dthis t.Perform =3D _IBP t.SetActive =3D _IBSetA t.SetInactive=3D _IBSetI t.SetPressed =3D _IBSetP t.SetDisabled=3D _IBSetD t.Enabled =3D _IBSetE t.ChangeIcon =3D null t.UserAction =3D action t.ChgState =3D _IBUI t.mObjId =3D oId t.mBorderId=3D bId t.mWidth =3D w t.mIsOn =3D t.mCurState =3D 0 } function _IBSetA() { if( this.mIsOn ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _IBSetI() { if( this.mIsOn ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0=20 } } function _IBSetP() { if( this.mIsOn ) { obj=3Dthis.ChgState( gShadowClr,gHiliteClr,2 ) obj.style.posLeft+=3D1; obj.style.posTop+=3D1 } } function _IBSetD() { =20 obj=3Dthis.ChgState( gFaceClr,gFaceClr,0 ) obj.style.posTop=3D0=20 } function _IBSetE( state ) { var t=3Dthis GetObj( t.mBorderId ).style.visibility=3D"visible" if( state !=3D t.mIsOn ) { t.mIsOn=3Dstate if( state ) t.SetInactive() else t.SetDisabled() } } function _IBP() { var t=3Dthis if( t.mIsOn ) { if( t.UserAction !=3D null ) t.UserAction() if( t.ChangeIcon ) { obj=3DGetObj(t.mObjId) if( t.ChangeIcon() ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-4)*t.mWidth else obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-0)*t.mWidth } t.SetActive() } =20 } function _IBUI( clr1,clr2,nextState ) { var t=3Dthis SetBorder( GetObj( t.mBorderId ),clr1,clr2 ) obj=3DGetObj( t.mObjId ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-nextState)*t.mWidth-obj= .style.posTop t.mCurState=3DnextState return obj } //----------------------------------------- function TxtBtn( oId,oeId,action,chkState ) //----------------------------------------- { var t=3Dthis t.Perform =3D _TBP t.SetActive =3D _TBSetA t.SetInactive=3D _TBSetI t.SetPressed =3D _TBSetP t.SetDisabled=3D _TBSetD t.SetEnabled =3D _TBSetE t.GetState =3D chkState t.UserAction =3D action t.ChgState =3D _TBUI t.mObjId =3D oId t.m_elementsId=3D oeId t.mIsOn =3D 1 } function _TBSetA() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gHiliteClr,gShadowClr,0,0 ) } function _TBSetI() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) } function _TBSetP() { if( this.mIsOn ) this.ChgState( gShadowClr,gHiliteClr,1,1 ) } function _TBSetD() { =20 this.ChgState( gFaceClr,gFaceClr,0,0 ) this.mIsOn =3D 0 } function _TBSetE() { var t=3Dthis if( !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) else t.ChgState( gShadowClr,gHiliteClr,1,1 ) t.mIsOn =3D 1 } function _TBP() { var t=3Dthis if( t.mIsOn ) {=20 if( t.UserAction !=3D null ) t.UserAction() if( !t.GetState ) return if( t.GetState() ) t.SetPressed() else t.SetActive() } =20 } function _TBUI( clr1,clr2,lOffset,tOffset ) { SetBorder( GetObj( this.mObjId ),clr1,clr2 ) Offset( GetObj( this.m_elementsId ),lOffset,tOffset ) } function Offset( obj, top, left ){ obj.style.top=3Dtop; obj.style.left=3Dle= ft } function SetBorder( obj, upperLeft, lowerRight ) { s=3Dobj.style; s.borderStyle =3D "solid" s.borderWidth =3D 1=20 s.borderLeftColor =3D s.borderTopColor =3D upperLeft s.borderBottomColor=3D s.borderRightColor =3D lowerRight } function GetBtnObj(){ return gBtnArr[window.event.srcElement.id] } function BtnOnOver(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetActive() } function BtnOnDown(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetPressed() } function BtnOnOut(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetInactive() } function BtnOnUp() { b=3DGetBtnObj() if( b !=3D null ) b.Perform() else Upd() } function GetNtsState(){ return parent.gNtsOpen } function GetOtlState(){ return parent.gOtlOpen } function GetOtlTxtState(){ return parent.gOtlTxtExp } function NtsBtnSetFlag( fVal ) { s=3Ddocument.all.item( this.m_flagId ).style s.display=3D"none" if( fVal ) s.display=3D"" else s.display=3D"none" } function _BSetA_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etActive() } function _BSetI_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etInactive() } function _BSetP_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etPressed() } function _BSetA_BorderImg() {=20 b =3D gBtnArr[this.mBorderId]=20 if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _BSetI_BorderImg() {=20 b =3D gBtnArr[this.mBorderId] if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0 } } var gHiliteClr=3D"THREEDHIGHLIGHT",gShadowClr=3D"THREEDSHADOW",gFaceClr=3D"= THREEDFACE" var gBtnArr =3D new Array() gBtnArr["nb_otl"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOtlPan= e,GetOtlState ) gBtnArr["nb_otlElem"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOt= lPane,GetOtlState ) gBtnArr["nb_nts"] =3D new ImgBtn( "nb_nts","nb_ntsBorder",10,parent.ToggleN= tsPane ) gBtnArr["nb_nts"].SetActive =3D _BSetA_BorderImg; gBtnArr["nb_nts"].SetInactive =3D _BSetI_BorderImg; gBtnArr["nb_ntsBorder"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.= ToggleNtsPane,GetNtsState ) gBtnArr["nb_ntsElem"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.To= ggleNtsPane,GetNtsState ) gBtnArr["nb_prevBorder"] =3D gBtnArr["nb_prev"]=3D new ImgBtn( "nb_prev","n= b_prevBorder",30,parent.GoToPrevSld ) gBtnArr["nb_nextBorder"] =3D gBtnArr["nb_next"]=3D new ImgBtn( "nb_next","n= b_nextBorder",30,parent.GoToNextSld ) gBtnArr["nb_sldshw"]=3D new ImgBtn( "nb_sldshw","nb_sldshwBorder",18,parent= .FullScreen ) gBtnArr["nb_sldshwBorder"] =3D new TxtBtn( "nb_sldshw","nb_sldshwBorder",pa= rent.FullScreen,null ) gBtnArr["nb_sldshwBorder"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwBorder"].SetInactive =3D _BSetI_Border; gBtnArr["nb_sldshwText"] =3D new TxtBtn( "nb_sldshw","nb_sldshwText",parent= .FullScreen,null ) gBtnArr["nb_sldshwText"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwText"].SetInactive =3D _BSetI_Border; gBtnArr["nb_voice"] =3D gBtnArr["nb_voiceBorder"] =3D new ImgBtn( "nb_voice= ","nb_voiceBorder",18,parent.ToggleVNarration ) gBtnArr["nb_otlTxtBorder"] =3D gBtnArr["nb_otlTxt"]=3D new ImgBtn( "nb_otlT= xt","nb_otlTxtBorder",23,parent.ToggleOtlText ) gBtnArr["nb_ntsBorder"].m_flagId=3D "nb_nts" gBtnArr["nb_ntsBorder"].SetFlag =3D NtsBtnSetFlag gBtnArr["nb_otlTxt"].ChangeIcon=3D GetOtlTxtState /********************************************* Context menu implementation _CM() is the function that's hooked up to the oncontextmenu event. Once we're asked to show the menu, we first build it by creating DIVs on-the-fly. Then we position it=20 within the screen area so it doesn't get clipped. Creating the DIVs using createElement() means we don't have to write out any extra HTML into the slide HTML files. **********************************************/ var sNext=3D"Siguiente",sPrev=3D"Anterior",sEnd=3D"Fin de la presentaci&oac= ute;n",sFont=3D"Arial",sArrow=3D"Flecha",sFreeform=3D"Forma libre",sRect=3D= "Rectángulo",sOval=3D"Óvalo" function ShowMenu() { BuildMenu(); var doc=3DPPTSld.document.body,x=3DPPTSld.event.clientX+doc.scrollLeft,y= =3DPPTSld.event.clientY+doc.scrollTop m =3D PPTSld.document.all.item("ctxtmenu") m.style.pixelLeft=3Dx if( (x+m.scrollWidth > doc.clientWidth)&&(x-m.scrollWidth > 0) ) m.style.pixelLeft=3Dx-m.scrollWidth m.style.pixelTop=3Dy if( (y+m.scrollHeight > doc.clientHeight)&&(y-m.scrollHeight > 0) ) m.style.pixelTop=3Dy-m.scrollHeight m.style.display=3D"" } function _CM() { if( !parent.IsFullScrMode() ) return; if(!PPTSld.event.ctrlKey) { ShowMenu() return false } else HideMenu() } function BuildMenu() { if( PPTSld.document.all.item("ctxtmenu") ) return var mObj=3DCreateItem( PPTSld.document.body ) mObj.id=3D"ctxtmenu" mObj.style.visibility=3D"hidden" var s=3DmObj.style s.position=3D"absolute" s.cursor=3D"default" s.width=3D"120px" SetCMBorder(mObj,"menu","black") var iObj=3DCreateItem( mObj ) SetCMBorder( iObj, "threedhighlight","threedshadow" ) iObj.style.padding=3D2 CreateMenuItem( iObj,sNext,M_GoNextSld,M_True ) CreateMenuItem( iObj,sPrev,M_GoPrevSld,M_HasPrevSld ) =09 CreateSeparator( iObj ) CreateMenuItem( iObj,sEnd,M_End,M_True ) mObj.style.visibility=3D"visible" } function Cancel() { window.event.cancelBubble=3Dtrue; window.event.returnVa= lue=3Dfalse } function Highlight() { ChangeClr("activecaption","threedhighlight") } function Deselect() { ChangeClr("threedface","menutext") } function Perform() { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) e.Action() else PPTSld.event.cancelBubble=3Dtrue } function ChangeClr( bg,clr ) { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) { e.style.backgroundColor=3Dbg e.style.color=3Dclr } } function M_HasPrevSld() { return( parent.HasPrevSld() ) } function M_GoNextSld() { if( gIsEndShow ) M_End(); else GoToNextSld() } function M_GoPrevSld() { if( gIsEndShow ) { gIsEndShow=3D0; history.back();= PPTSld.event.cancelBubble=3Dtrue; } else GoToPrevSld() } function M_True() { return true } function M_End() { window.close( self ) } function CreateMenuItem( node,text,action,eval ) { var e=3DCreateItem( node ) e.type=3D"menuitem" e.Action=3Daction e.IsActive=3Deval e.innerHTML=3Dtext if( !e.IsActive() ) e.style.color=3D"threedshadow" e.onclick=3DPerform e.onmouseover=3DHighlight e.onmouseout=3DDeselect s=3De.style; 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charset="us-ascii" Hemostasia. Farmacos Antihemorrágicos ------=_NextPart_01C7842B.A1942810 Content-Location: file:///C:/E31BBA37/sangre1-2006-07_archivos/outline.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii"
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