DEPARTAMENTO DE QUÍMICA FARMACÉUTICA Y ORGÁNICA

Universidad de Granada |
DEPARTAMENTO DE QUÍMICA FARMACÉUTICA Y ORGÁNICADEPARTAMENTO DE QUÍMICA FARMACÉUTICA Y ORGÁNICA
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Investigación y desarrollo de fármacos (Drug design and development). Grupo CTS 130

Director: Joaquín María Campos Rosa.

Investigadores:

  • Joaquín María Campos Rosa.
  • Antonio Jose Entrena Guadix.
  • María Encarnación Camacho Quesada.
  • María José Pineda de las Infantas y Villatoro.
  • Ana Conejo García.
  • María Dora Carrión Peregrina.
  • Olga Cruz López.
  • Luisa Carlota López Cara.
  • José Manuel Espejo Román.
  • Álvaro Lorente Macías.

Líneas de Investigación:

  • a. Diseño y síntesis de fármacos neuroprotectores.

    b. Diseño y síntesis de nuevos inhibidores de colina quinasa con actividad antitumoral

    c. Diseño y síntesis de compuestos antitumorales y/o antivirales con estructura aciclo- y nucleosídica.

    d. Diseño y síntesis de compuestos quirales con actividad antitumoral.

Proyectos de investigación :

  • 1. Título: Sintesis de kinurenaminas con actividad neuroprotectora frente al daño mitocondrial inducido por el sistema NOS/NO. Entidad Financiadora: Instituto de Salud Carlos 111. PI021181

    2. Título: Evaluación de kinurenaminas sinteticas como neuroprotectores frente al daño mitocondrial inducido por el sistema NOS/NO en parkinson experimental. Entidad Financiadora: CICYT (SAF2002-01688)

    3. Título: Diseño, síntesis y evaluación biológica de nuevos inhibidores selectivos de mtNOS e iNOS. Entidad Financiadora: CICYT (SAF2005-07991-C02-02)

    4. Título: Anillos benzofusionados O,N-acetálicos de siete y ocho miembros, obtenidos mediante síntesis en fase sólida, con actividad anticancerosa. Entidad Financiadora: Junta de Andalucía (Código del Proyecto: 00636, Proyecto de Excelencia)

    5. Título: Design, synthesis and biological studies of novel 1,4-benzoxazepines as antitumour compounds; Entidad Financiadora: Unión Europea

    6. Título: Convocatoria de infraestructura científico-tecnológica (2005-2006) Entidad Financiadora: Ministerio de Educación y Ciencia y FEDER

    7. Título: Nuevos derivados antitumorales, benzo o pirido fusionados a heterociclos de siete miembros O,N-acetálicos unidos a bases pirimidínicas y púricas, y compuestos relacionables. Entidad financiadora: Instituto Carlos 111, FIS PI030225

    8. Título: Nuevos fármacos gemelos anticancerosos O,N-acetálicos tetrahidrobenzoxazepínicos con bases pirimidínicas o púricas. Entidad financiadora: Instituto Carlos III, FIS PI041206

    9. Título: Diseño, síntesis y evaluación biológica de nuevos inhibidores selectivos de mtNOS e iNOS. Entidad financiadora: Junta de Andalucía. (P06-CTS-01941)

    10. Título: Nuevos heterociclos homoquirales de alto valor añadido obtenidos a partir de bencenos disustituidos en posición orto: binomio estereoquímica-actividad antitumoral. Entidad financiadora: Instituto Carlos 111, FIS PI070227

    11. Título: Choline Kinase: an important target for cancer, malaria and filariasis. Entidad financiadora: Ministerio de Ciencia e Innovación. (HD2008-0028)

    12. Título: Diseño de fármacos con actividad antiproliferativa: nuevos inhibidores mejorados de colina quinasa Entidad financiadora: Junta de Andalucía (P07-CTS-032190).

    13. Título: Diseño y síntesis de nuevos inhibidores mejorados de colina quinasa como potenciales fármacos con actividad antiproliferativa Entidad financiadora: Ministerio de Ciencia e Innovación (SAF2009-11955).

    14. Título: Diseño y síntesis de nuevos heterociclos oxigenados de siete y ocho miembros benzofusionados como fármacos con actividad antiproliferativa frente a cáncer de mama. Entidad financiadora: Ministerio de Ciencia e Innovación (SAF2010-18263).

    . Título: nuevos heterociclos homoquirales de alto valor añadido obtenidos a partir de bencenos disustituídos en posición orto: binomio estereoquímica-actividad antitumoral. Instituto Carlos III, FIS PI070227.

    16.- TITULO: CHOLINE KINASE: AN IMPORTANT TARGET FOR CANCER, MALARIA AND FILARIASIS. ACCIONES INTEGRADAS HISPANO-ALEMANAS, CONVOCATORIA 2008. MINISTERIO DE CIENCIA E INNOVACIÓN. Código del Proyecto: HD2008-0028.

    17.- TITULO: IX JORNADAS DE LA SOCIEDAD ESPAÑOLA DE QUÍMICA TERAPÉUTICA. ACCIONES COMPLEMENTARIAS DENTRO DEL SUBPROGRAMA DE ACCIONES COMPLEMENTARIAS A PROYECTOS DE INVESTIGACIÓN FUNDAMENTAL NO ORIENTADA. CONVOCATORIA 2010. MINISTERIO DE CIENCIA E INNOVACIÓN. Referencia: SAF2010-08941-E (subprograma).

    18.- TITULO: INNOVADORES O,N-ACETALES ACÍCLICOS DE 5-FLUOROURACILO Y DERIVADOS PURÍNICOS DI- Y TRI-SUSTITUIDOS COMO HERRAMIENTAS FARMACOLÓGICAS PARA EL TRATAMIENTO DE CÉLULAS MADRE CANCEROSAS. INSTITUTO CARLOS III, FIS PI10/00592.

    19.- TITULO: IX JORNADAS DE LA SOCIEDAD ESPAÑOLA DE QUÍMICA TERAPÉUTICA. ACTIVIDAD CIENTÍFICA DE LA JUNTA DE ANDALUCÍA (La Resolución corresponde a la Secretaría General de Universidades, Investigación y Tecnología de 10 de marzo de 2011 (BOJA de 5 de abril de 2011). Referencia: fecha 5 de abril de 2011 y referencia /905/11 del Vicerrectorado de Política Científica e Investigación, Servicio de Gestión de Investigación.

    20.- TITULO: PROGRAMA CIÉNCIA SEM FRONTEIRAS – BOLSAS NO PAÍS MODALIDADE. PESQUISADOR VISITANTE ESPECIAL – PVE. CHAMADA DE PROJETOS Nº 03/2014. COVERED AREA: Drugs. MEC/MCTI/CAPES/CNPq/FAPs (Brasil).

    21.- TITULO: Desarrollo de fármacos frente a células madre tumorales (CSCs) mediante cribado de librerías sintéticas utilizando GPCRs, quinasas y la interacción calcineurina-NFAT como dianas. SECRETARÍA DE ESTADO DE INVESTIGACIÓN, DESARROLLO E INNOVACIÓN SECRETARÍA GENERAL DE CIENCIA, TECNOLOGÍA E INNOVACIÓN DIRECCIÓN GENERAL DE INNOVACIÓN Y COMPETITIVIDAD SUBDIRECCIÓN GENERAL DE COLABORACIÓN PÚBLICO-PRIVADA. ( RTC-2015-3386-1).

    22.- TITULO: Mejora de la actividad anticancerosa del bozepinib, bozinib y derivados, mediante la introducción del grupo trifluorometilo . Junta de Andalucía . (CS2016.1).

    23.- TITULO: Small molecules with anti-angiogenic effect. The Granada Research of Excellence Initiative on BioHealth (GREIB)_START-UP PROJECTS FOR YOUNG RESEARCHERS. the Campus of International Excellence of the Ministry of Science and Innovation (Class B, R+D+I – Top ResearchAreas) GREIB.PYR_2011_15. (2011 HASTA 2012)

    24.- TITULO: “Búsqueda de nuevos fármacos antimaláricos: Diseño, Síntesis y Evaluación Biológica de nuevos compuestos como potenciales inhibidores de la colina quinasa en Plasmodium falciparum”. CEI-Biotic UGR-Granada(22/05/ 2013 HASTA 31/12/2013).

    25.- TITULO: Pequeñas moléculas con actividad antiprolifertiva y antiangiogénica . Consejería de Innovación Ciencia y Empleo de la Junta de Andalucía Proyectos de Excelencia. (2014 HASTA /2017).

Patentes:

  • 1. Autores: Juan Carlos Lacal; Joaquín María Campos Rosa; Miguel Ángel Gallo Mezo; Antonio Espinosa Úbeda; Título: Derivados de piridinio y quinolinio. Patente solicitud nº: P200400072 (14/01/2004)

    2. Autores: Juan Carlos Lacal; Joaquín María Campos Rosa; Miguel Ángel Gallo Mezo; Antonio Espinosa Úbeda; Título: Derivados de piridinio y quinolinio. Patente solicitud nº: W0506842A 1 (28/07/2005)

    3. Autores: Antonio Espinosa Úbeda; Darío Acuña Castroviejo; Miguel Ángel Gallo Mezo; Antonio José Entrena Guadix; Encarnación Camacho Quesada; Germaine Escames Rosa; María Dora Carrión Peregrina; Luisa Carlota López Cara: Título: Inhibidores de la óxido nítrico sintasa (NOS) con actividad neuroprotectora. Patente solicitud nº: P200601917 (07/07/2006)

    4. Autores: Antonio Espinosa Ubeda; Darío Acuña Castroviejo; Miguel Ángel Gallo Mezo; Antonio José Entrena Guadix; Encarnación Camacho Quesada; Germaine Escames Rosa; María Dora Carrión Peregrina; Luisa Carlota López Cara: Título: 3-Benzoilpirazoles inhibidores de la óxido nítrico sintasa (NOS) con actividad neuroprotectora. Patente solicitud nº: P200702478 (07/07/2006)

    5. Autores: Joaquín María Campos Rosa; Antonio Espinosa Ubeda; Miguel Ángel Gallo Mezo; José Antonio Gómez Vidal; María Del Carmen Núñez Carretero; Antonia Aránega Jiménez; Título: (2,3-Dihidro-5H-1 ,4-benzodiheteroepin-3-il)purinas con actividad antitumoral; Patente solicitud nº: P0601538 (24/05/2006)

    6. Autores: Ana Conejo García; Luisa Carlota López Cara; Juan Antonio Marchal Corrales; Fernando Rodríguez Serrano; Miguel Ángel Gallo Mezo; Houria Boulaiz ; Antonio Espinosa Úbeda; Joaquín María Campos Rosa; Antonia Aránega Jiménez; Título: Nuevas (RS)-7- ó 9-(1 ,2,3,5-tetrahidro-4, 1-benzoxazepin-3-il)-7H ó 9H-purinas con actividad antitumoral; Patente solicitud nº: P200802431 (07/08/2008).

    7. Autores: Marchal Corrales, Juan Antonio; Aránega Jiménez, Antonia; Conejo García, Ana; García Chaves, María Ángeles; Cruz López, Olga; Boulaiz, Houria; Rodríguez Serrano, Fernando; Cativiela Marín, Carlos; Perán Quesada, Macarena; Jiménez Sanz, Ana Isabel; García Ruiz, Juan Manuel; Choquesillo Lazarte, Duane; Campos Rosa, Joaquín María. TITULO: Enantiómeros de derivados benzoheteroepínicos y su uso como agentes anticancerígenos. Patente solicitud nº: P201030415, (22/03/2010).

    8.- AUTORES: Gamarro Conde, Francisco; Campos Rosa, Joaquín María; Castanys Cuello, Santiago; Gómez Pérez, Verónica; García Hernández, Raquel; Manzano González, José Ignacio. TITULO: Derivados ciclofánicos de bis-piridinio como fármacos antiprotozoarios. Nº DE REGISTRO: P201231534, 5 de octubre de 2012.

    9.- AUTORES: Campos Rosa, Joaquín M.; Conejo García, Ana; Marchal Corrales, Juan Antonio; Morales Marín, Fátima; Morata Tarifa, Cynthia; Ramírez Rivera, Alberto. TÍTULO: Sulfonamidas derivadas de aminas secundarias con grupos 1,3-dioxolanilalquílicos y fenilmetilpurínicos, y su utilización como agentes anticancerígenos. Nº DE REGISTRO: P201430048, 20 de enero de 2014.

    10.- AUTORES: Campos Rosa, Joaquín M; Marchal Corrales, Juan A., García Rubiño, Mª Eugenia, Morata Tarifa, Cynthia, Ramírez Rivera, Alberto. TÍTULO: BENZO-HETEROCICLOS DE SEIS MIEMBROS CON ÁTOMOS DE OXÍGENO Y NITRÓGENO CON ACTIVIDAD ANTITUMORAL. P201630714. 31/05/2016.

Publicaciones (seleccionadas):

    1. A. Unciti-Broceta, M. J. Pineda de las Infantas, J. J. Díaz-Mochón, R. Romagnoli, P. G. Baraldi, M. A. Gallo, A. Espinosa. Regioselective one-pot synthesis of 9-alkyl-6 chloropyrido[3,2-e][1 ,2,4]triazolo[4,3-a]pyrazines. Reactivity of aliphatic and aromatic hydrazides. J. Org. Chem., 2005, 70, 2878-2880.

    2. G. Costantino, A. Entrena Guadix, A. Macchiarulo, A. Gioiello, R. Pellicciari; Molecular Dynamics Simulation of the Ligand Binding of Farnesoid X Receptor. Insights into Helix-12 Stability and Coactivator Peptide Stabilization in Response to Agonist Binding. J. Med. Chem., 2005, 48, 3251-3259.

    3. R. Sánchez-Martín, J. M. Campos, A. Conejo-García, O. Cruz-López, M. Báñez-Coronel, A. Rodríguez-González, M. A. Gallo, J. C. Lacal, A. Espinosa. Symmetrical Bis-Quinolinium Compounds: New Human Choline Kinase Inhibitors with Antiproliferative Activity against the HT-29 Cell Line. J. Med. Chem., 2005, 48, 3354-3363

    4. J. M. Campos, E. Saniger, J. A. Marchal, S. Aiello, 1. Suárez, H. Boulaiz, M. A. Gallo, A. Espinosa; New Medium Oxacyclic O,N-Acetals and Related Open Analogues: Biological Activities. Curr. Med. Chem., 2005, 12, 1423-1438

    5. A. Conejo-García, J. Campos, C. Eder, M. A. Gallo, A. Espinosa: Synthesis and NMR Studies on a C3-Symmetrical Triquinolina Triscationic Bicyclophane. J. Org. Chem., 2005, 70, 5748-5751

    6. A. Entrena, M. E. Camacho, M. D. Carrión, L. C. López Cara, G. Velasco, J. León, G. Escames, D. Acuña-Castroviejo, V. Tapias, M. A. Gallo, A. Vivó, A. Espinosa. Kynurenamines as Neural Nitric Oxide Synthase Inhibitors. J. Med. Chem., 2005, 48, 8174-8181

    7. J. M. Campos, R. M. Sánchez-Martín, A. Conejo-García, A. Entrena, M. A. Gallo, A. Espinosa. (Q)SAR Studies to Design New Human Choline Kinase Inhibitors as Antiproliferative Drugs. Curr. Med. Chem., 2006, 13, 1231-1248

    8. L. Milanese, A. Espinosa, J. M. Campos, M. A. Gallo, A. Entrena. Insight into the Inhibition of Choline Kinase by Ca2+ Ion: Homology Modeling and Molecular Dynamics Simulations. Chem. Med. Chem., 2006, 1, 1216-1228

    9. R. Pellicciari, A, Gioiello, G. Costantino, B. M. Sadeghpour, G. Rizzo, U. Meyer, D. J. Parks, A. Entrena-Guadix, S. Fiorucci. Back Door Modulation of the Farnesoid X Receptor (FXR): Design, Synthesis and Biological Evaluation of a Series of Side Chain-Modified Chenodeoxycholic Acid Derivatives. J. Med. Chem., 2006, 49, 4208-4215

    10. L. C. López-Cara, M. E. Camacho, M. D. Carrión, M. A. Gallo, A. Espinosa, A. Entrena; An unexpected aromatization during the N-alkylation reaction of 3,4-dihydro-1H-pyrazole derivatives: Insight into the reaction mechanism. Tetrahedron Lett., 2006, 47, 6239-6242.

    11. J. León, G. Escames, M. 1. Rodríguez, L. C. López, V. Tapias, A. Entrena, M. E Camacho, M. D. Carrión, M.A. Gallo, A. Espinosa, D. X. Tan, R. J. Reiter, D. Acuña-Castroviejo. Inhibition of neuronal nitric oxide synthase activity by N1-acetyl-5-methoxykynurenamine, a brain metabolite of melatonin. J. Neurochem., 2006, 98, 2023-2033

    12. R. Romagnolli, P. G. Baraldi, V. Remusat, M. D. Carrión, L. C. López Cara, L. C.; et al. Synthesis and biological evaluation of 2-(3,4,5-trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors. J. Med. Chem., 2006, 49, 6425-6428

    13. O. Cruz-López, J. J. Díaz-Mochón, J. M. Campos, A. Entrena, M. T. Núñez, L. Labeaga, A. Orjales, M. A. Gallo, A. Espinosa. Design, Syntheses, Biological Evaluation, and Docking Studies of 2-Substituted 5-Methylsulfonyl-1-Phenyl-1H-Indoles: Potent and Selective in vitro Cyclooxygenase-2 Inhibitors. Chem. Med. Chem., 2007, 2, 88-100

    14. P. G. Baraldi, D. Preti, M. A. Tabrizi, F. Fruttarolo, R. Romagnoli, M. D. Carrión, L. C. López, et al. Synthesis and Biological Evaluation of Novel 1-Deoxy-1-[6-(hetero)arylcarbonyl)hydrazino]-9H-purin-9-yl]-N-ethyl-beta-D-ribofuranuronamide Derivatives as Useful Templates for the Development of A2B Adenosine Receptor Agonists. J. Med. Chem., 2007, 50, 374-380

    15. J. A. Marchal, M. C. Núñez, Suárez, M. Díaz-Gavilán, H. Boulaiz, F. Rodríguez- Serrano, A. Aránega, M. A. Gallo, A. Espinosa, J. M. Campos. A synthetic uracil derivative with antitumor activity through decreasing cyclin D1 and Cdk1, and increasing p21 and p27 in MCF-7 cells. Breast Cancer Research and Treatment, 2007, 105, 237-246.

    16. M. C. Núñez, A. Conejo-García, R. M. Sánchez-Martín, M. A. Gallo, A. Espinosa, J. M. Campos. QSAR as a Tool for the Development of Potent Antiproliferative Agents by Inhibition of Choline Kinase. Current Computer-Aided Drug Design, 2007, 3, 297-312.

    17. A. García-Navarro, C. González-Puga, G. Escames, L. C. López, A. López, M. López-Cantarero, E. Camacho, A. Espinosa, M. A. Gallo, D. Acuña-Castroviejo. Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture. J. Pineal Res., 2007, 43,195-205.

    18. A. Unciti-Broceta, M. J. Pineda de las Infantas, M. A. Gallo, A. Espinosa. Reduction of different electron-poor N-heteroarylhydrazines in strong basic conditions. Chemistry- A European Journal, 2007, 13, 1754-1762.

    19. M. D. Carrión, L. C. López Cara, M. E. Camacho, V. Tapias, G. Escames, D. Acuña- Castroviejo, A. Espinosa, M. A. Gallo, A. Entrena. Pyrazoles and pyrazolines as Neural and Inducible Nitric Oxide Synthase (nNOS and iNOS) Potential lnhibitors (III). Eur. J. Med. Chem., 2008, 43, 2579-2591

    20. J. A. Marchal, F. Rodríguez-Serrano, O. Caba, A. Aránega, M. A. Gallo, A. Espinosa, J. M. Campos. Antiproliferative Activity, Cell Cycle Dysregulation and Cellular Differentiation of Salicyl- and Catechol-Derived Acyclic 5-Fluorouracil O,N-Acetals Against Breast Cancer Cells. Chem. Med. Chem., 2008, 2, 1814-1821.

    21. M. Díaz-Gavilán, A. Conejo-García, O. Cruz-López, M. C. Núñez, D. Choquesillo- Lazarte, J. M. González-Pérez, F. Rodríguez-Serrano, J. A. Marchal, A. Aránega, M. A. Gallo, A. Espinosa, J. M. Campos. "Synthesis and Anticancer Activity of (RS)-9-(2,3-Dihydro-1,4-Benzoxathiin-3-ylmethyl)-9H-Purines". Chem. Med. Chem., 2008, 3, 127-135.

    22. A. Conejo-García, M. C. Núñez, J. A. Marchal, F. Rodríguez-Serrano, A. Aránega, M. A. Gallo, A. Espinosa, J. M. Campos. Regioespecific Microwave-Assisted Synthesis and Cytotoxic Activity against Human Breast Cancer Cells of (RS)-6-Substituted-7- or 9-(2,3-Dihydro-5H-1 ,4-Benzodioxepin-3-yl)-7H- or -9H-Purines". Eur. J. Med. Chem., 2008, 43, 1742-1748.

    23. A. Conejo-García, M. A. Gallo, A. Espinosa, J. M. Campos. Latest advances on Regioespecific Microwave-Assisted Synthesis of Novel Purine Derivatives as Antitumour Agents. Expert Opinion Ther. Patents, 2008, 12, 212-222.

    24. A. Conejo-García, J. M. Campos. Bis-Quinolinium Cyclophanes: Highly Potent and Selective Non-Peptidic Blockers of the Apamin-Sensitive Ca2+-Activated K+ Channel. Curr. Med. Chem., 2008, 15, 1305-1315.

    25. M. A. Gallo, A. Espinosa, J. M. Campos. Thermal N-9' → N-7' Isomerization of (6'- Substituted)-9-(2,3-Dihydro-5H-1 ,4-Benzodioxepin-3-yl)-9H-Purines in Solution: Mechanistic Aspects. Mini-Reviews in Organic Chemistry, 2008, 5, 128-133.

    26. M. C. Núñez, M. Díaz-Gavilán, A. Conejo-García, O. Cruz-López, M. A. Gallo, A. Espinosa, J. M. Campos. Design, Synthesis and Anticancer Activity against the MCF-7 Cell Une of Benzo-Fused 1,4-Dihetero Seven- and Six-Membered Tethered Pyrimidines and Purines. Curr. Med. Chem., 2008, 15, 2614-2631.

    27. J. A. Marchal, M. C. Núñez, A. Aránega, M. A. Gallo, A. Espinosa, J. M. Campos. Acyclonucleosides, Modified Seco-Nucleosides, and Salicyl- or Catechol-Derived Acyclic 5-Fluorouracil O,N-Acetals: Antiproliferative Activities, Cellular Differentiation and Apoptosis. Curr. Med. Chem., 2009, 16, 1166-1183

    28. M. C. Núñez, M. E. García-Rubiño, A. Conejo-García, O. Cruz-López, M. Kimatrai, M. A. Gallo, A. Espinosa, J. M. Campos. Homochiral Drugs: a Demanding Tendency of the Pharmaceutical Industry. Curr. Med. Chem., 2009, 16, 2064-2074

    29. L. C. López-Cara; M. E. Camacho, M. D. Carrión, V. Tapias, M. A. Gallo, G Escames, D. Acuña-Castroviejo, A. Espinosa, A. Entrena. Phenylpyrrole derivatives as neural and inducible nitric oxide synthase (nNOS and iNOS) inhibitors. European Journal of Medicinal Chemistry, 2009, 44, 2655-2666

    30. V. Tapias, G. Escames, L. López, A. López, E. Camacho, A. Entrena, M. D. Carrión, M. A. Gallo, A. Espinosa, D. Acuña-Castroviejo. Melatonin and its brain metabolite N1- acetyl-5-methoxykynurenamine prevents mitochondrial nitric oxide synthase induction in Parkinsonian mice. Journal of Neuroscience Research, 2009, 87, 3002-3010

    31. A. Bruno, A. Entrena, G. Costantino. Dynamics Simulation of the Heterodimeric mGluR2/5HT 2A Complex. An Atomistic Resolution Study of a Potential New Target in Psychiatric Conditions. J. Chem. Inf. Model., 2009, 49 (6), 1602-1616

    32. R. Romagnoli , P.G. Baraldi , O.M. Cruz López, L.C. Lopez Cara and D. Preti , Alfa-Halogenoacrylic derivatives of antitumor agents. Mini-Reviews in Medicinal Chemistry, 2009, 9, 81-94.

    33. A. Entrena Guadix and G. Costantino, Synthesis and biological evaluation of 4,5-Diphenyloxazolone derivatives on route towards selective COX-2 inhibitors, European Journal of Medicinal Chemistry, 2009, 44, 1830-1837.

    34. R. Romagnoli , P.G. Baraldi , M.D. Carrión Peregrina, O.M. Cruz López, L.C. López Cara, J. Balzarini , E. Hamel and R. Gambari , "Hybrid alpha-Bromoacryloylamido chalcones. Design, synthesis and biological evaluation", Bioorganic & Medicinal Chemistry Letters, vol.19, 2022-2024, 2009.

    35. R. Romagnoli , P.G. Baraldi , M.D. Carrión Peregrina, O.M. Cruz López, L.C. López Cara, J. Balzarini , E. Hamel and R. Gambari , Discovery of 8-Methoxypyrazino[1,2-A]indole as a new potent antiproliferative agent against human leukemia k562 cells. A structure-Activity relationship study, Letters in Drug Design and Discovery, 2009, 5, 214-220.

    36. V. Tapias , G. Escames Rosa, L.C. López García, A. López Ramírez, E. Camacho Quesada, M.D. Carrión Peregrina, A. Entrena Guadix, M.A. Gallo Mezo, A. Espinosa Ubeda and D. Acuña Castroviejo, Melatonin and its brain metabolite n(1)-Acetyl-5-Methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice, Journal of Neuroscience Research, 2009, 87, 3002-3010.

    37. R. Romagnoli , P.G. Baraldi , M.D. Carrión Peregrina, O.M. Cruz López, L.C. López Cara, J. Balzarini and E. Hamel. "Alfa-Arylamino-4-Amino-5-Aroylthiazoles. One-Pot" Synthesis and Biological Evaluation of a New Class of Inhibitors of Tubulin Polymerization. Journal of Medicinal Chemistry, 2009, 52, 5551-5555.

    38. L. C. López Cara, M.J. Pineda De Las Infantas Villatoro, M.D. Carrión Peregrina, E. Camacho Quesada, M.A. Gallo Mezo, A. Espinosa úbeda and A.J. Entrena Guadix. NMR and Conformational Studies of New 5-Phenylpyrrole-Carboxamide Derivatives. Magnetic Resonance in Chemistry, 2009, 47, 1101-1107.

    39. M. C. Núñez Carretero, M.E. Garcia Rubiño, A. Conejo García, O.M. Cruz López, M. Kimatrai Salvador, M.A. Gallo Mezo, A. Espinosa Ubeda and J.M. Campos Rosa. Design, Synthesis and Anticancer Activity against the MCF-7 Cell Line of Benzo-Fused 1,4-Dihetero Seven- and Six-Membered Tethered Pyrimidines and Purines. Current Medicinal Chemistry, 2009, 16, 1166-1183.

    40. G. Eren, S. Ünlü, M. T. Nuñez, L. Labeaga, F. Ledo, A. Entrena, E. Banoglu, G. Costantino, M. F. Sahin. Synthesis, biological evaluation, and docking studies of novel heterocyclic diaryl compounds as selective COX-2 inhibitors. Bioorganic & Medicinal Chemistry, 2010, 18, 6367–6376.

    41. M. Kimatrai, O. Cruz-López, M. E. García-Rubiño, F. Morales, V. Gómez-Pérez, J. M. Campos. Neighbouring-Group Participation Involving the Oxygen Atom of the O,O- or O,N-Acetal Functional Groups. Curr. Org. Chem., 2010, 14, 1461-1477.

    42. A. Unciti-Broceta, M. J. Pineda-de-las-Infantas, M. Á. Gallo, A. Espinosa. Synthesis of 9-alkyl-6-amino[1,2,4]triazolo[3,4-c]-5-azaquinoxalines. Mild and effective SNAr amination of highly electron-poor heterocycles. Tetrahedron Letters, 2010, 51 2262–2264.

    43.- A. Conejo-García, O. Cruz-López, V. Gómez-Pérez, F. Morales, M. E. García-Rubiño, M. Kimatrai, M. C. Núñez, J. M. Campos. Synthesis of Purine Derivatives as Scaffolds for a Diversity of Biological Activities. Curr. Org. Chem., 2010, 14, 2463-2482.

    44.- Olga Cruz-López, Ana Conejo-García, María C. Núñez, María Kimatrai, M. Eugenia García-Rubiño, Fátima Morales, Verónica Gómez-Pérez, Joaquín M. Campos. Novel Substituted Quinazolines for Potent EGFR Tyrosine Kinase Inhibitors. Curr. Med. Chem., 2011, 18, 943-963.

    45.- Olga Cruz-López, María C. Núñez, Ana Conejo-García, María Kimatrai, Joaquín M. Campos. Syntheses of 2,3-Dihydro-1,4-Benzodioxins and Bioisosteres as Structural Motifs for Biologically Active Compounds. Curr. Org. Chem., 2011, 15, 869-887.

    46.- Luisa C. López-Cara, Ana Conejo-García, Juan A. Marchal, Giuseppe Macchione, Olga Cruz-López, Houria Boulaiz, María A. García, Fernando Rodríguez-Serrano, Alberto Ramírez, Carlos Cativiela, Ana I. Jiménez, Juan M. García-Ruiz, Duane Choquesillo-Lasarte, Antonia Aránega, Joaquín M. Campos. New (RS)-Benzoxazepin-Purines with Antitumor Activity: The Chiral Switch from (RS)-2,6-Dichloro-9-[1-(p-Nitrobenzenesulfonyl)-1,2,3,5-Tetrahydro-4,1-Benzoxazepin-3-yl]-9H-Purine. Eur. J. Med. Chem., 2011, 46, 249-258.

    47.- García M.A., Carrasco E, Aguilera M, Alvarez P, Rivas C, Campos J.M., Prados, J.C., Calleja M.A., Esteban M, Marchal J.A., Aránega A. The chemotherapeutic drug 5-fluorouracil promotes PKR-mediated apoptosis in a p53-independent manner in colon and breast cancer cells. PLoS ONE, 2011, 6, e23887.

    48.- Ana Conejo-García, Leonardo Pisani, Maria del Carmen Núñez, Marco Catto, Orazio Nicolotti, Francesco Leonetti, Joaquín M. Campos, Miguel A. Gallo, Antonio Espinosa, Angelo Carotti. Homo- and Hetero-dimeric bis-Quaternary Heterocyclic Ammonium Salts as Potent Acetyl- and Butyryl-cholinesterase Inhibitors: A Systematic Investigation of the Influence of Linker and Cationic Heads over Affinity and Selectivity. J. Med. Chem., 2011, 54, 2627-2645.

    49.- Octavio Caba, Mónica Díaz-Gavilán, Fernando Rodríguez-Serrano, Houria Boulaiz, Antonia Aránega, Miguel A. Gallo, Juan A. Marchal, Joaquín M. Campos. Anticancer Activity and cDNA Microarray Studies of (RS)-1,2,3,5-Tetrahydro-4,1-Benzoxazepine-3-yl]-6-Chloro-9H-Purines, and Acyclic (RS)-O,N-Acetalic 6-Chloro-7H-Purines. Eur. J. Med. Chem., 2011, 46, 3802-3809.

    50.- Ana Conejo-García, M. Eugenia García-Rubiño, Juan A. Marchal, M. Carmen Núñez, Alberto Ramírez, Sandro Cimino, M. Ángel García, Antonia Aránega, Miguel A. Gallo, Joaquín M. Campos. Synthesis and Anticancer Activity of (RS)-9-(2,3-Dihydro-1,4-Benzoxa-heteroin-2-ylmethyl)-9H-Purines. Eur. J. Med. Chem., 2011, 46, 3795-3801.

    51.- María Kimatrai, Ana Conejo-García, Alberto Ramírez, Elena Andreolli, María Ángel García, Antonia Aránega, Juan A. Marchal, Joaquín M. Campos. Synthesis and Anticancer Activity of the (R,S)-Benzofused 1,5-Oxathiepine Moiety Tethered to Purines through Alkylidenoxy Linkers. ChemMedChem, 2011, 6, 1854-1859.

    52.- M. Eugenia García-Rubiño, Duane Choquesillo-Lazarte, M.C. Nuñez and Joaquín M. Campos. Two tautomeric polymorphs of 2,6-dichloropurine. Acta Crystallographica Section C, 2011, C67, o484-o486.

    53.- O. Caba, F. Rodríguez-Serrano, Mónica Díaz-Gavilán, A. Conejo-García, P. Álvarez, R. Ortiz, A. Martínez-Amat, J. M. Campos, M. A. Gallo, J. A. Marchal, A. Aránega. The Selective Cytotoxic Activity in Breast Cancer Cells by an Anthranilic Alcohol-Derived Acyclic 5-Fluorouracil O,N-Acetal is Mediated by Endoplasmic Reticulum Stress-induced Apoptosis. Eur. J. Med. Chem., 2012, 50, 376-382.

    54.- Gómez-Perez, Veronica; McSorley, Theresa; See Too, Wei Cun; Konrad, Manfred; Campos, Joaquin M. Novel 4-Amino Bis-Pyridinium and Bis-Quinolinium compounds as Choline Kinase Inhibitors with Antiproliferative Activity against the SKBR-3 Cell Line. ChemMedChem, 2012, 7, 663-669.

    55.- M. Eugenia García-Rubiño, María C. Núñez, Miguel A. Gallo, Joaquín M. Campos. Synthesis, unambiguous chemical characterization, and reactivity of 2,3,4,5-tetrahydro-1,5-benzoxazepines-3-ol. RSC Adv., 2012, 2, 12631-12635.

    56.- Benedetto Natalini, Roccaldo Sardella, Federica Ianni, María Eugenia García-Rubiño, Ana Conejo-García, María del Carmen Núñez, Miguel Angel Gallo, Joaquín María Campos. Chromatographic Enantioresolution of Six Purine Derivatives Endowed with Anti-Human Breast Cancer Activity. Chromatographia, 2013, 76 (9-10), 475-482.

    57.- Juan Antonio Marchal, Esther Carrasco, Alberto Ramírez, Gema Jiménez, Carmen Olmedo, Macarena Perán, Amad Agil, Ana Conejo-García, Olga Cruz-López, Joaquín María Campos, María Ángel García. Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα, triggering apoptosis, autophagy and senescence. Drug Design, Development and Therapy, 2013, 7, 1301-1313.

    58.- M. Eugenia García-Rubiño, Ana Conejo-García, María C. Núñez, Esther Carrasco, María A. García, Duane Choquesillo-Lazarte, Juan M. García-Ruiz, Miguel A. Gallo, Juan A. Marchal, Joaquín M. Campos. Enantiospecific Synthesis of Heterocycles Linked to Purines: Different Apoptosis Modulation of Enantiomers in Breast Cancer Cells. Curr. Med. Chem., 2013, 20, 4923-4934.

    59.- Sahún-Roncero, María; Rubio-Ruiz, Belén; Saladino, Giorgio; Conejo-García, Ana; Espinosa, Antonio; Velázquez-Campoy, Adrián; Gervasio, Francesco Luigi; Entrena, Antonio; Hurtado-Guerrero, Ramón. The Mechanism of Allosteric Coupling in Choline Kinase α1 Revealed by the Action of a Rationally Designed Inhibitor. Angewandte Chemie, International Edition, 2013, 52(17), 4582-4586.

    60.- Fátima Morales, Alberto Ramírez, Ana Conejo-García, Cynthia Morata, Juan A. Marchal, Joaquín M. Campos. Anti-proliferative Activity of 2,6-Dichloro-9- or 7-(Ethoxycarbonylmethyl)-9H- or 7H-Purines against Several Human Solid Tumour Cell Lines. Eur. J. Med. Chem., 2014, 76, 118-124.

    61.- M. Eugenia García-Rubiño, Nawal Mahfoudh, Joaquín M. Campos. Structural Elucidation Errors in Organic Chemistry. Curr. Org. Chem., 2014, 18(11), 1513-1519.

    62.- Verónica Gómez-Perez, José Ignacio Manzano, Raquel García-Hernández, Santiago Castanys, Joaquín Mª Campos, Francisco Gamarro. 4-Amino bis-pyridinium derivatives as novel antileishmanial agents. Antimicrob. Agents Chemother., 2014, 58(7), 4103-4112.

    63.- Alberto Ramírez, Houria Boulaiz, Cynthia Morata-Tarifa, Macarena Perán, Gema Jiménez, Manuel Picón-Ruiz, Ahmad Agil, Olga Cruz-López, Ana Conejo-García, Joaquín M. Campos, Ana Sánchez, María A. García, Juan A. Marchal. HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib. Oncotarget, 2014, 5(11), 3590-3606.

    64.- M. E. García-Rubiño, M. C. Núñez-Carretero, D. Choquesillo-Lazarte, J. M. García-Ruiz, Yolanda Madrid, J. M. Campos. Stereospecific Alkylation of Substituted Adenines by the Mitsunobu Coupling Reaction under Microwave-Assisted Conditions. RSC Adv., 2014, 4, 22425-22433.

    65.- Verónica Gómez-Pérez, José Ignacio Manzano, Raquel García-Hernández, Santiago Castanys, Francisco Gamarro, Joaquín M. Campos. Design, synthesis and anti-leishmanial activity of novel symmetrical bispyridinium cyclophanes. Eur. J. Med. Chem., 2015, 89, 362-369.

    66.- Fernando C. Torres, M. Eugenia García-Rubiño, César Lozano, Joaquín M. Campos. Imidazoles and benzimidazoles as tubulin-binding anti-tumour agents. Curr. Med. Chem., 2015, 22(11), 1312-1323.

    67.- Juan Carlos Lacal, Joaquín Campos. Preclinical characterization of RSM-932A, a novel anticancer drug targeting the human choline kinase alpha, an enzyme involved in increased lipid metabolism of cancer cells. Mol. Cancer Ther., 2015, 14(1), 31-39.

    68.- Fátima Morales, Ana Conejo-García, Alberto Ramírez, Cynthia Morata, Juan Antonio Marchal and Joaquín M. Campos. p-Nitrobenzenesulfonamides and their fluorescent dansylsulfonamides derived from N-alkylated o-(purine-methyl)anilines as novel antitumour agents. RSC Adv., 2015, 5, 76615-76619.

    69.- María E. García-Rubiño, César Lozano-López and Joaquín M. Campos. Inhibitors of Cancer Stem Cells. Anti-Cancer Agents in Medicinal Chemistry, 2016, 16(10), 1230-1239.

    70.- Fátima Morales, Joaquín M. Campos, Ana Conejo-García. 1H and 13C NMR spectral data of p-nitrobenzenesulfonamides and dansylsulfonamides derived from N-alkylated o-(purinemethyl)anilines. Magn. Reson. Chem. 2016, 54(9), 760-770.

    71.- Evelyn Mirella Lopes Pina Diniz, Carlos Henrique Tomich de Paula da Silva, Verónica Gómez-Perez, Leonardo Bruno Federico & Joaquín María Campos Rosa. GRIND2-based 3D-QSAR and prediction of activity spectra for symmetrical bis-pyridinium salts with promastigote antileishmanial activity. Journal of Biomolecular Structure and Dynamics, 2016, 35(11), 2430-2440.

    72.- Fátima Morales, Alberto Ramírez, Cynthia Morata-Tarifa, Saúl A. Navarro, Juan A. Marchal, Joaquín M. Campos and Ana Conejo-García. Anti-tumoural Activity of 1,2-Diaminocyclohexane Derivatives in Breast, Colon and Skin Human Cancer Cells. Future Med. Chem., 2017, 9(3), 293-302.

    73.- Olga Cruz-López, Alberto Ramírez, Saúl A. Navarro, Juan A. Marchal, Joaquín M. Campos and Ana Conejo-García. 1-(Benzenesulfonyl)-1,5-dihydro-4,1-benzoxazepine as a new scaffold for the design of antitumour compounds. Future Med. Chem., 2017, 9(11):1129-1140.

    74.- Pernomian, Larissa; Preto Gomes, Mayara; da Silva, Carlos Henrique; Campos, Joaquín. Reverse Induced Fit-Driven MAS-Downstream Transduction: Looking for Metabotropic Agonists. Curr. Med. Chem., 2017, 24, 1-8.

    75.- Pernomian, Larissa; Preto Gomes, Mayara; da Silva, Carlos Henrique; Campos, Joaquín. Reverse Induced Fit -Driven MAS -Downstream Transduction: Looking for Metabotropic Agonists. Curr. Med. Chem., 2017, 24, 1-8.

    76.- Leonardo B. Federico, Cleydson B. R. dos Santos, Cleison C. Lobato, Jaquelinne S. Gomes, Joaquín M. Campos Rosa and Carlos H. T. P. da Silva. Ligand- and structure-based drug design of novel calcium channel blockers. J. Comput. Theor. Nanosci., 2017, 14(7), July 2017, 3489-3502.

    77.- Gino Del Ponte, Fernando C. Archanjo, Lilian Y. Watanabe, Paulo M. Donate, Joaquín M. Campos. Syntheses of Non-Aromatic Medium and Large Rings Synthesized via Phenylnitrenium Ions. Arabian J. Chem., 2018, 11, 415-425.

    78.- Nawal Mahfoudh, Nagore I. Marín-Ramos, Ana M. Gil, Ana I. Jiménez, Duane Choquesillo-Lazarte, Daniel F. Kawano, Joaquín M. Campos, Carlos Cativiela. Cysteine-Based 3-Substituted 1,5-Benzoxathiepin Derivatives: Two New Classes of Anti-proliferative Agents. Arabian J. Chem., 2018, 11, 426-441.

    79.- Federico LB, Alcântara LM, Moraes CB, Freitas LH, Rosa JMC, Carlos HTP Silva (2018). Discovery of Novel Leishmanicidal Drugs with Potential L-type Calcium Channel Blockage, Designed by Similarity-Based Virtual Screening Approaches. POJ Pharma Sci., 2018, 1(1), 1-6

    80.- A Carrión, M.D.; López-Cara, L.C.; Camacho, M.E.; Entrena, A.; Gallo, M.A.; Espinosa, A. Structural elucidation of new Δ-2-pyrazoline derivatives using 1H and 13C NMR spectroscopy. Magnetic Resonance in Chemistry 2005, (43), 1063-1065

    Romagnoli,R.; Baraldi,P.G.; Pavani, M.G.; Tabrizi, M.A.; Iaconinoto, M.A.; Carrión, M.D.; Lopez-Cara, L.C.; Shryock, J. C.; Leung, E.; Moorman, A.R.; Gessi, S.; Merighi, S.; Borea, P.A. Synthesis and biological evaluation of allosteric A1-adenosine receptor modulators structurally related to (2-amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(4-chloro-phenyl)-methanone, a potent compound useful to reduce neuropathic pain Medicinal Chemistry Research, 2005, (14),3, 125-142

    Baraldi, P.G.; Zaid, A.N.; Preti, D.; Fruttarolo, F.; Trabizi, M.A.; Iaconinoto, A.; Pavani, M.G.; Carrión, M.D.; López Cara, C.; Romagnoli, R Hybrid molecules based on distmycin A as potential antitumor agents. Arkivoc 2006, (7), 20-34.

    Romeo Romagnoli, Pier Giovanni Baraldi, Allan R-Moornan, Maria Antonietta Iaconinoto, Maria Dora Carrion, Carlota Lopez Cara, Mojgan Aghazadeh Tabrizi, Delia Preti, Francesca Frutarollo, Stephen P. Baker, Katia Varani, Pier Andrea Borea. Microwave-Assisted Synthesis of Thieno[2,3-c]pyridine Derivatives as New Potential Series of Allosteric Enhancers at A1-Adenosine Receptor. Bioorganic and Medicinal Chemistry Letters 2006, (16), 5530-5533

    Pier Giovanni Baraldi, Delia Preti, Mojgan Aghazadeh Tabrizi, Francesca Fruttarolo, Romeo Romagnoli, Maria Dora Carriona, Luisa Carlota López Cara, Allan R. Moorman, Katia Varani, Pier Andrea Borea. Synthesis and Biological Evaluation of Novel 1-Deoxy-1-[6-[((hetero)aryl-carbonyl)-hydrazino]-9H-purin-9-yl]-N-ethyl--D-ribofuranuronamide Derivatives as Useful Template for the Development of A2B Adenosine Receptor Agonists. Journal of Medicinal Chemistry 2007, (50), 374-380

    Romeo Romagnoli, Pier Giovanni Baraldi, Maria Dora Carrion, Carlota Lopez Cara, Delia Preti, Francesca Fruttarolo, Maria Giovanna Pavani, Mojgan Aghazadeh Tabrizi, Manlio Tolomeo, Stefania Grimaudo, Antonella Di Cristina, Jan Balzarini, John A. Hadfield, Andrea Brancale and Ernest Hamel. Synthesis and Biological Evaluation of 2-and 3-Amino Benzo[b]Thiophene Derivatives as Antimitotic Agents and Inhibitors of Tubulin Polymerization. Journal of Medicinal Chemistry 2007, (50), 2273-2277

    Baraldi, P.G.; Iaconinoto, M.A.; Moorman, A.R.; Carrion, M.D.; Lopez Cara, C.; Preti, D.; Fruttarolo, F.; Trabizi, M.A.; Romagnoli, R. Allosteric enhancers for A1 adenosine receptor Mini-Reviews in Medicinal Chemistry 2007, (7), 559-569

    Romagnoli, Romeo; Baraldi, Pier Giovanni; Carrion, Maria Dora; Cara, Carlota Lopez; Preti, Delia; Cruz-Lopez, Olga; Tabrizi, Mojgan Aghazadeh; Moorman, Allan R.; Gessi, Stefania; Fogli, Eleonora; Sacchetto, Valeria; Borea, Pier Andrea From Tyrosine to Glycine: Synthesis and Biological Activity of Potent Antagonists of the Purinergic P2X7 Receptor Journal of Medicinal Chemistry 2007, (50), 3706-3715

    Romagnoli,R.; Baraldi, P.G.; Remusat, V.; Carrión, M.D.; Lopez Cara, C.;Cruz Lopez, O.; Preti, D.; Fruttarolo, F.; Trabizi, M.A.; Balzarini, J.;Hamel, E Synthesis and biological evaluation of 2-amino-3-(3´,4´,5´- trimethoxyphenylsulfonyl)-5-aryl thiophenes as a new class of Antitubulin Agents. Medicinal Chemistry 2007, (3), 507- 512

    Romagnoli, R.; Baraldi, P.G.; Lopez Cruz, O.; Carrion, M.D.; Lopez Cara,C.; Preti, D.; Trabizi, M.A.; Balzarini, J. Microwave-assisted synthesis of substituted 2,4-diarylthiazoles and their evaluation as anticancer agents. Letters in Drug Design and Dicovery 2007, (4), 464- 466

    Romagnoli R, Baraldi PG, Sarkar T, Carrion MD, Cara CL, Cruz-Lopez O, Preti D, Tabrizi MA, Tolomeo M, Grimaudo S, Di Cristina A, Zonta N, Balzarini J, Brancale A, Hsieh HP, Hamel E. Synthesis and Biological Evaluation of 1-Methyl-2-(3',4',5'-trimethoxybenzoyl)-3-aminoindoles as a New Class of Antimitotic Agents and Tubulin Inhibitors. Journal of Medicinal Chemistry, 2008, (51) 1464-1468.

    Romeo Romagnoli, Pier Giovanni Baraldi, Olga Cruz Lopez, Maria Dora Carrion, Carlota Lopez Cara, Jan Balzarini, Enrica Fabbri, Robero Gambari. Synthesis and biological evaluation of a series of 2-(3,4,5-trimethoxybenzoyl)-indol-3-yl acetic acid derivatives as potential agents against human leukemia K562 cells. Letters in Drug Design and amp; Dicovery, 2008, 5(3), 214-220

    Luisa C. López-Cara, M. Dora Carrión, M. Encarnación Camacho, Miguel A. Gallo, Antonio Espinosa, Duane Choquesillo-Lazarte, Josefa M. Gonzalez-Pérez and Antonio Entrena Guadix.1H, 13C NMR, X-ray and conformational studies of new 1-alkyl-3-benzoyl-pyrazole and 1-alkyl-3-benzoyl-pyrazoline derivatives. Magnetic Resonance in Chemistry, 2008, 46(9), 878-885

    Romagnoli, Romeo; Baraldi, Pier Giovanni; Carrion, Maria Dora; Cara, Carlota Lopez; Cruz-Lopez, Olga; Preti, Delia; Tolomeo, Manlio; Grimaudo, Stefania; Di Cristina, Antonella; Zonta, Nicola; Balzarini, Jan; Brancale, Andrea; Sarkar, Taradas; Hamel, Ernest. Design, synthesis, and biological evaluation of thiophene analogues of chalcones Bioorganic & Medicinal Chemistry, 2008, 16(10), 5367-5376

    Romagnoli, Romeo; Baraldi, Pier Giovanni; Cruz-Lopez, Olga; Lopez-Cara, Carlota; Preti, Delia; Borea, Pier Andrea; Gessi, Stefania The P2X7 receptor as a therapeutic target. Expert Opinion on Therapeutic Targets, 2008, 12(5), 647-661

    Romeo Romagnoli, Pier Giovanni Baraldi, Taradas Sarkar, Carlota Lopez Cara, Olga Cruz Lopez, Maria Dora Carrion, Delia Preti, Manlio Tolomeo, Jan Balzarini, Ernest Hamel. Synthesis and biological evaluation of 2-aroyl-4-phenyl-5-hydroxybenzofurans as a new class antitubulin agents. Medicinal Chemistry, 2008, (4), 558-564

    Romeo Romagnoli, Pier Giovanni Baraldi, Taradas Sarkar, Maria Dora Carrion, Olga Cruz-Lopez Carlota Lopez-Cara, Manlio Tolomeo, Stefania Grimaudo, Antonella Di Cristina, Maria Rosaria Pipitone, Jan Balzarini, Roberto Gambari, Lampronti Ilaria, Roberto Saletti, Andrea Brancale, Ernest Hamel. Synthesis and Biological Evaluation of 2-(3’,4’,5’-Trimethoxybenzoyl)-3-N,N-Dimethylamino Benzo[b]furan Derivatives as Inhibitors of Tubulin Polymerization. Bioorganic & Medicinal Chemistry, 2008, 16(18), 8419-26

    Romeo Romagnoli, Pier Giovanni Baraldi, Maria Dora Carrion, Olga Cruz-Lopez, Carlota Lopez-Cara, Manlio Tolomeo, Stefania Grimaudo, Antonella Di Cristina, Maria Rosaria Pipitone, Jan Balzarini, Sahara Kandile, Andrea Brancale, Taradas Sarkar and Ernest Hamel. Synthesis and Biological Evaluation of 2-Amino-3-(3’,4’,5’-Trimethoxybenzoyl)-6 Substituted-4,5,6,7-Tetrahydrothieno[2,3-c]pyridine Derivatives as Antimitotic Agents and Inhibitors of Tubulin Polymerization. Bioorganic & Medicinal Chemistry Letters, 2008, 18(18), 5041-5

    Romeo Romagnoli, Pier Giovanni Baraldi, Maria Dora Carrion, Carlota Lopez Cara, Olga Cruz-Lopez, Maria Antonietta Iaconinoto, Delia Preti, John C. Shryock, Allan R. Moorman, Fabrizio Vincenzi, Katia Varani, and Pier Andrea Borea. Synthesis and Biological Evaluation of 2-Amino-3-(4-Chlorobenzoyl)-4-[N-(Substituted) Piperazin-1-yl]Thiophenes as Potent Allosteric Enhancers of the A1 Adenosine Receptor. Journal of Medicinal Chemistry, 2008, 51(18), 5875-5879

    Karen S. MacMillan, James P. Lajiness, Carlota Lopez Cara, Romeo Romagnoli, William M. Robertson, Inkyu Hwang, Pier Giovanni Baraldi, Dale L. Boger. Synthesis and evaluation of a thio analogue of duocarmycin SA. Bioorganic & Medicinal Chemistry Letters, 2009, 19, 6962–6965

    Romagnoli, Romeo; Baraldi, Pier Giovanni; Carrion, Maria Dora; Cara, Carlota Lopez; Cruz-Lopez, Olga; Tolomeo, Manlio; Grimaudo, Stefania; Di Cristina, Antonietta; Pipitone, Maria Rosaria; Balzarini, Jan; Zonta, Nicola; Brancale, Andrea; Hamel, Ernest. Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization. Bioorganic & Medicinal Chemistry, 2009 17(19), 6862-6871

    Romeo Romagnoli, Pier Giovanni Baraldi, Olga Cruz-Lopez, Carlota Lopez Cara, Maria Dora Carrion, Jan Balzarini, Ernest Hamel, Giuseppe Basso, Roberta Bortolozzi, Giampietro Viola. Symmetrical α-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation. Bioorganic & Medicinal Chemistry Letters, 2010, 20(9), 2733-2739

    R. Romagnoli, P. G. Baraldi, O. Cruz-Lopez, L. C. Lopez-Cara, M. D. Carrion, A. Brancale, H. Hamel, C. Longchuan, G. Basso, G. Viola Synthesis and Antitumor Activity of 1,5-Disubstituted 1,2,4-Triazoles as cis-Restricted Combretastatin Analogues Journal of Medicinal Chemistry, 2010, 53(10), 4248-4258

    Romeo Romagnoli, Pier Giovanni Baraldi, Maria Dora Carrion,Carlota Lopez Cara, Alberto Casolari, Ernest Hamel, Enrica Fabbri and Roberto Gambari Bromoacryloyl and Nitrooxyacetyl Benzo[b]furan and Benzo[b]thiophene Derivatives as Potent Antiproliferative Agents Against Leukemia L1210 and K562 Cells Letters in Drug Design & Discovery, 2010, 7(4), 476- 486

    Romeo Romagnoli, Pier Giovanni Baraldi, Carlota Lopez Cara, Ernest Hamel, Giuseppe Basso, Ronberta Bortolozzi, Gianpietro Viola Synthesis and Biological of 2-(3’,4’,5’-Trimethoxybenzoyl)-3-Aryl/ArylAminoBenzo[b]Thiophene Derivatives as Novel Class of Antiproliferative Agents European Journal of Medicinal Chemistry, 2010, 5781-5791

    Romeo Romagnoli, Pier Giovanni Baraldi, Carlota Lopez Cara, Olga Cruz-Lopez, Maria Dora Carrion, Maria Kimatrai Salvador, Jaime Bermejo, Sara Estévez, Francisco Estévez, Jan Balzarini, Andrea Brancale, Antonio Ricci,Longchuan Chen, Jae Gwan Kim, Ernest Hamel Synthesis and Antitumor Molecular Mechanism of Agents Based on Amino on Amino 2-(3’,4’,5’-Trimethoxybenzoyl)- benzo[b]furan: Inhibition of Tubulin and Induction of Apoptosis ChemMedChem.2011,6, 1841-1853,

    Romeo Romagnoli, Pier Giovanni Baraldi, Carlota Lopez Cara, Maria Kimatrai Salvador, Roberta Bortolozzi, Giuseppe Basso, Giampietro Viola, Jan Balzarini,Andrea Brancale, Xian-Hua Fu, Jun Li, Su-Zhan Zhang, Ernest Hamel One-Pot Synthesis and Biological Evaluation of 2-Pyrrolidinyl-4-Amino-5-(3’,4’,5’-Trimethoxybenzoyl)Thiazole: a Unique, Highly Active Antimicrotubule Agents. European Journal of Medicinal Chemistry, 2011, 6015-6024

    Romeo Romagnoli, Pier Giovanni Baraldi, Maria Dora Carrion, Carlota Lopez Cara, Olga Cruz-Lopez, Maria Kimatrai Salvador, Delia Preti, Mojgan Aghazadeh Tabrizi, John C. Shryock, Allan R. Moorman, Fabrizio Vincenzi, Katia Varani, Pier Andrea Borea Structure–activity relationships of 2-amino-3-aroyl-4-[(4-arylpiperazin-1-yl)methyl]thiophenes. Part 2: Probing the influence of diverse substituents at the phenyl of the arylpiperazine moiety on allosteric enhancer activity at the A1 adenosine receptor Bioorg. & Med. Chem., 2012 20, 996–1007.

    Luisa C. López Cara, M. Dora Carrión, Antonio Entrena, Miguel A. Gallo, Antonio Espinosa, Ana López, Germaine Escames, Darío Acuña-Castroviejo, M. Encarnación Camacho1,3,4-Thiadiazole Derivatives as Selective Inhibitors of iNOS versus nNOS European Journal of Medicinal Chemistry, 2012, 50, 129-139

    M. Encarnación Camacho, M. Dora Carrión, L. Carlota López-Cara, Antonio Entrena, M. A. Gallo, Antonio Espinosa, Germaine Escames, Darío Acuña-Castroviejo Melatonin Analogs as Nitric Oxide Synthase Mini Reviews in Medicinal Chemistry, 2012, 18, 600-617.

    M. Dora Carrión, Luisa C. López-Cara, Mariem Chayah, Duane Chosquesillo-Lazarte, Miguel A. Gallo, Antonio Entrena, Antonio Espinosa, and M. Encarnación Camacho Spectroscopy Characterization by NMR Studies of New 2,3-Dihydro-1,3,4-Thiadiazole Derivatives. Magnetic Resonance in Chemistry, 2012, 50(7), 515-522.

    Romeo Romagnoli, Pier Giovanni Baraldi, Maria Dora Carrion, Carlota Lopez Cara, Olga Cruz-Lopez, Maria Kimatrai Salvador, Delia Preti, Mojgan Aghazadeh Tabrizi, Allan R. Moorman, Fabrizio Vincenzi, Pier Andrea Borea, and Katia Varani Synthesis and Biological Evaluation of 2-Amino-3-(4-chlorobenzoyl)-4-[(4-arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. Effect of the 5-Modification on Allosteric Enhancer Activity at the A1 Adenosine Receptor Journal of Medicinal Chemistry, 2012, 13;55 (17):7719-35.

    Santiago Schiaffino-Ortega, Luisa Carlota López-Cara, Maria Kimatrai Salvador In silico pharmacology for a multidisciplinary drug discovery process Drug Metabolism and Drug Interactions 2012, 27, 4 199-207

    Romeo Romagnoli, Pier Giovanni Baraldi, Maria Dora Carrion, Carlota Lopez Cara, Maria Kimatrai Salvador, Delia Preti, Mojgan Aghazadeh Tabrizi, Allan R. Moorman, Fabrizio Vincenzi, Pier Andrea Borea, Katia Varani Synthesis and Biological Effects of Novel 2-Amino-3-(4-Chlorobenzoyl)-4-Substituted Thiophenes as Allosteric Enhancers of the A1 Adenosine Receptor European Journal of Medicinal Chemistry, 2013, 67, 409-427

    Romagnoli, Romeo; Baraldi, Pier Giovanni; Lopez Cara, Carlota; Delia, Preti; Aghazadeh Tabrizi, Mojgan; Balzarini, Jan; Brancale, Andrea; Bassetto, Marcella; Fu, Xian-Hua; Gao, Yang; Li, Jun; Zhang, Su-Zhan; Hamel, Ernest; Basso, Giuseppe; Bortolozzi, Roberta; Viola, Giampietro Concise Synthesis and Biological Evaluation of 2-Aroyl-5-Amino Benzo[b]thiophene Derivatives As a Novel Class of Potent Antimitotic Agents Journal of Medicinal Chemistry, 2013, 56, 9296-9309,

    Santiago Schiaffino-Ortega, Luisa Carlota López-Cara, Pablo Ríos-Marco, Maria Paz Carrasco-Jimenez, Carmen Marco, Miguel A. Gallo, Antonio Espinosa, Antonio Entrena. New non-symmetrical choline kinase inhibitors Bioorg. & Med. Chem. 2013, 21, 7146–7154

    Romagnoli, Romeo; Baraldi, Pier Giovanni; Carrion, Maria Dora; Cruz-Lopez, Olga; Lopez-Cara, Carlota; Saponaro, Giulia; Preti, Delia; Aghazadeh Tabrizi, Mojgan; Baraldi, Stefania; Moorman, Allan; Borea, Pier Andrea; Vincenzi, Fabrizio; Varani, Katia Synthesis and Biological Evaluation of Novel 2-Amino-3-Aroyl-4-Neopentyl-5-Substituted Thiophene Derivatives as Allosteric Enhancers of the A1 Adenosine Receptor Bioorg. & Med. Chem., 2014, 22, 148-166

    Romeo Romagnoli, Pier Giovanni Baraldi, Carlota Lopez-Cara, Maria Kimatrai Salvador, Delia Preti, Mojgan Aghazadeh Tabrizi, Jan Balzarini, Peter Nussbaumer, Marcella Bassetto, Andrea Brancale, Xian-Hua Fu, Yang-Gao, Jun Li, Su-Zhan Zhang, Ernest Hamel, Roberta Bortolozzi, Giuseppe Basso and Giampietro Viola Design, Synthesis and Biological Evaluation of 3,5-Disubstituted 2-Amino Thiophene Derivatives As a Novel Class of Antitumor Agents Bioorg. & Med. Chem., 2014, 22, 5097- 5109.

    Santiago Schiaffino-Ortega, Miguel A. Gallo, Antonio Espinosa, Luisa Carlota López-Cara*, Antonio Entrena. 1H, 13C NMR studies of new 3-aminophenol isomers linked to pyridinium salts Magnetic Resonance in Chemistry, 2014, 52, 40-46

    Romagnoli, Romeo; Baraldi, Piergiovanni; IJzerman, Adriaan; Massink, Arnault; Cruz-Lopez, Olga; Lopez-Cara, Carlota; Saponaro, Giulia; Preti, Delia; Aghazadeh Tabrizi, Mojgan; Baraldi, Stefania; Moorman, Allan; Vincenzi, Fabrizio; Borea, Pier Andrea; Varani, Katia Synthesis and Biological Evaluation of Novel Allosteric Enhancers of the A1 Adenosine Receptor Based on 2-Amino-3-(4’-Chlorobenzoyl)-4-Substituted-5-Arylethynyl Thiophene Journal of Medicinal Chemistry, 2014, 57, 7673−7686

    Serran-Aguilera L, Nuti R, López-Cara LC, Ríos-Marco P, Carrasco MP, Marco C, Entrena A, Macchiarulo A, Hurtado-Guerrero R. Choline Kinase Active Site Provides Features for Designing Versatile Inhibitors Current Topic In Medicinal Chemistry, 14(23), 2684-2693, 2014

    Francisco Fermin Castro-Navas, Santiago Schiaffino-Ortega, Maria Paz Carrasco-Jimenez, Pablo Ríos-Marco, Carmen Marco, Antonio Espinosa, Miguel Angel Gallo, Giuseppe Basso, Roberta Borolozzi, Giampietro Viola, Antonio Entrena, Luisa Carlota López-Cara*. New more polar symmetrical bipyridinic compounds: new strategy for the inhibition of choline kinase α1 Future of Medicinal Chemistry, 2015 (7/(58) Vol. 7, No. 4, Pages 417-436.

    Lucía Serrán-Aguilera, Roberto Nuti, Luisa C. López-Cara, Miguel Á. Gallo Mezo, Antonio Macchiarulo, Antonio Entrena, and Ramón Hurtado-Guerrero Pharmacophore-based virtual screening to discover new active compounds for human choline kinase α1 Molecular Informatics, 2015, 34, 458-466.

    Romagnoli, Romeo; Baraldi, Pier Giovanni; Salvador, Maria; Prencipe, Filippo; Lopez-Cara, Luisa; Schiaffino, Santiago; Brancale, Andrea; Hamel, Ernest; Castagliuolo, Ignazio; Mitola, Stefania; Ronca, Roberto; Bortolozzi, Roberta; Porcù, Elena; Basso, Giuseppe; Viola, Giampietro Design, Synthesis, in Vitro and in Vivo Anticancer and Antiangiogenic Activity of Novel 3-Arylamino Benzofuran Derivatives Targeting the Colchicine Site on Tubulin Journal of Medicinal Chemistry, 2015, 5, 58, 3209−3222

    Romagnoli, Romeo; Baraldi, Pier Giovanni; Lopez-Cara, Luisa; Cruz-López, Olga; Moorman, Allan R .; Massink, Arnault; IJzerman, Adriaan; Vincenzi, Fabrizio; Borea, Pier Andrea; Varani, Katia Synthesis and Biological Evaluation of a New Series of 2-Amino-3-Aroyl Thiophene Derivatives as Agonist Allosteric Modulators of the A1 Adenosine Receptor. A Position-Dependent Effect Study European Journal of Medicinal Chemistry, 2015, 101, 185–204

    Santiago Schiaffino-Ortega, Eleonora Baglioni,, Elena Mariotto, Roberta Bortolozzi, Lucía Serrán-Aguilera, Pablo Ríos-Marco, M. Paz Carrasco-Jimenez, Miguel A. Gallo, Ramon Hurtado-Guerrero, Carmen Marco, Giuseppe Basso Giampietro Viola* Antonio Entrena,* Luisa Carlota López-Cara* Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1 Sci. Rep. 6, 23793; doi: 10.1038/srep23793 (2016).

    Romeo Romagnoli* , Pier Giovanni Baraldi , Filippo Prencipe, Carlota Lopez-Cara, Riccardo Rondanin, Daniele Simoni, Ernest Hamel, Stefania Grimaudo, Rosaria Maria Pipitone, Maria Meli, Manlio Tolomeo Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation European Journal of Medicinal Chemistry, 108 (2016), 39-52

    Romeo Romagnoli* Pier Giovanni Baraldi, Filippo Prencipe, Paola Oliva, Stefania Baraldi, Mojgan Aghazadeh Tabrizi, Carlota Lopez-Cara* , Salvatore Ferla, Andrea Brancale , Ernest Hamel , Roberto Ronca, Roberta Bortolozzi, Elena Mariotto, Giuseppe Basso and Giampietro Viola* Design and Synthesis of Potent in Vitro and in Vivo Anticancer Agents Based on 1-(3’,4’,5’-Trimethoxyphenyl)-2-Aryl-1H-Imidazole Sientific Reports, 2016, 6:26602 | DOI: 10.1038/srep26602

    M. José Pineda de las Infantas, M. Dora Carrión, Mariem Chayah, Luisa C. López-Cara , Miguel A. Gallo, Darío Acuña-Castroviejo, M. Encarnación Camacho Synthesis of oxadiazoline and quinazolinone derivatives and their biological evaluation as nitric oxide synthase inhibitors Medicinal Chemistry Research, 2016, 25,6, 1260-1273

    Giampietro Viola, Elena Mariotto, Roberta Bortolozzi, Roberto Ronca, Luisa Carlota Lopez Cara, Antonio Entrena and Giuseppe Basso. Potent in vitro and in vivo effects of EB-3D, a novel choline-kinase inhibitor in breast cancer The FASEB Journal, 2016, 30, 1 Supplements, 937.2-937.2

    Elena Mariotto, Roberta Bortolozzi, Roberto Ronca, Luisa C López-Cara, Benedetta Accordi, Valentina Serafin, Giuseppe Basso, Giampietro Viola In vitro and in vivo pharmacological study of EB-3D: a novel choline kinase inhibitor for breast cancer treatment Cancer Research 76, 14 Supplement Páginas 1233-1233, 2016

    Santiago Schiaffino-Ortega, María Kimatrai Salvador, Eleonora Baglioni, Miguel Angel Gallo, Antonio Entrena*, Luisa Carlota Lopez-Cara* 1H and 13C NMR spectral assignments of 1,1'-(((ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))-bispyridinium and –bisquinolinium bromide derivatives. Magnetic Resonance in Chemistry, 2016, Volume 54, Issue 11, Pages 905–911

    Romeo Romagnoli*, Pier Giovanni Baraldi, Filippo Prencipe, Paola Oliva, Stefania Baraldi, Mojgan Aghazadeh Tabrizi, Maria Kimatrai-Salvador, Luisa Carlota Lopez-Cara*, Andrea Brancale, Roberto Ronca, Roberta Bortolozzi Elena Mariotto, Giuseppe Bassoand Giampietro Viola* Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Tubulin Polymerization Inhibitors Scientific Reports,2017 7:46356

    Romeo Romagnoli*, Pier Giovanni Baraldi, Filippo Prencipe, Paola Oliva, Stefania Baraldi, Maria Kimatrai Salvador, Luisa Carlota Lopez-Cara, Roberta Bortolozzi, Elena Mattiuzzo, Giuseppe Basso and Giampietro Viola* Design, Synthesis and Biological Evaluation of 3-Substituted-2-Oxoindole Hybrid Derivatives as Novel Anticancer Agents European Journal of Medicinal Chemistry, 2017, 134, 258-270

    Romeo Romagnoli, Maria Kimatrai Salvador, Santiago Schiaffino Ortega, Pier Giovanni Baraldi, Paola Oliva, Stefania Baraldi, Luisa Carlota Lopez-Cara, Andrea Brancale, Salvatore Ferla, Ernest Hamel, Jan Balzarini, Sandra Liekens, Elena Mattiuzzo, Giuseppe Basso, Giampietro Viola 2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition European Journal of Medicinal Chemistry, 2018, 143, 683-698.

    F. Prencipe, L. C. Lopez-Cara, P. Oliva, S. Baraldi, P.G. Baraldi, F.Estévez-Sarmiento, J. Quintana, F. Estévez, Synthesis and Biological Evaluation of alpha-Bromoacryloylamido Indolyl Pyridinyl Propenones as Potent Apoptotic Inducers in Human Leukemia Cells. Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, 33, 1, 727–742.

Publicaciones (libros y capítulos de libros) :

    1.- La inhibición del enzima colina quinasa como una nueva terapia antiproliferativa, en “Avances en oncología básica y aplicada”. J. Campos, M. C. Núñez, Juan J. Díaz, Miguel A. Gallo, Antonio Espinosa. 2006, 561-582. Universidad de Granada, 683 páginas. Depósito Legal: GR/1507-2006. ISBN: 84-338-3907-1.

    2.- Synthesis and reactivity of 5-alkoxy-1,4-diheteroepanes and of medium acetalic benzo-fused oxacycles: Preparation of cyclic and acyclic uracil hemiaminals with notable biological activities. en “Modern Approaches to the synthesis of O- and N-Heterocycles” Editores: T. S. Kaufman y E. L. Larghi. Joaquín M. Campos, Mónica Díaz-Gavilán, Mª del Carmen Núñez, Miguel. A. Gallo, Antonio Espinosa. 2007, 99-127. Research Signpost, T. C. 37/661(2), Fort Post Office, Trivandrum - 695023, Kerala, India. ISBN: 978-81-308-0165-0.

    3.- Cyclophanes and bicyclophanes: Fascinating molecules in Organic Chemistry en “Targets in Heterocyclic Systems – Chemistry and Properties”; Vol 11. (Editores: Orazio A. Attanasi & Domenico Spinelli). Joaquín Campos, Ana Conejo-García, Antonio Entrena, Miguel A. Gallo, Antonio Espinosa. 2007, 431-448. Società Chimica Italiana. ISBN: 978-88-86208-52-9. ISSN: 1724-9449.

    4.- Therapeutic potential of differentiation in cancer and normal stem cells. en “New Cell Differentiation Research Trends”. Editor: Hitoshi Saitama. J. A. Marchal, H. Boulaiz, M. Perán, J. C. Prados, J. Campos, F. J. González, F. Rodríguez-Serrano, C. Melguizo, C. Vélez, E. Carrillo, F. Hita, R. Ortiz, A. Martínez-Amat, O. Caba, C. Ventura, A. Aránega. 2008, 7-77. Nova Science Publishers, Inc., 400 Oser Avenue, Suite 1600, Hauppauge, NY 11788, EE UU. ISBN 1-60021-937-3.

    5.- Química Fina Farmacéutica. Encarnación Camacho Quesada y Joaquín M. Campos Rosa. 2008, 1-209. Editorial Universidad de Granada. Depósito Legal: GR./99-2008. ISBN: 978-84-338-4800-0.

    6.- Synthetic Routes and Pharmacology of Top drugs en “Current Methods in Medicinal Chemistry and Biological Physics, vol. 2”, Capítulo 11 (Editores: Carlton A. Taft & Carlos H. T. P. Silva). Joaquín M. Campos, M. Encarnación Camacho. 2008, 215-247. Research Signpost, T. C. 37/661(2), Fort Post Office, Trivandrum - 695023, Kerala, India. ISBN: 978-81-308-0292-3.

    7.- Therapeutic Potential of Differentiation in Cancer and Normal Stem Cells. Authors / Editors: J. A. Marchal, H. Boulaiz, M. Perán, J. C. Prados, J. Campos, F. J. González, F. Rodríguez-Serrano, C. Melguizo, C. Vélez, E. Carrillo, F. Hita, R. Ortiz, A. Martínez-Amat, O. Caba, C. Ventura, A. Aránega. 2008, 7-77. Binding: Softcover. Nova Science Publishers, Inc., 400 Oser Avenue, Suite 1600, Hauppauge, NY 11788, EE UU. ISBN 978-1-60692-917-9.

    8.- Therapeutic Potential of Differentiation in Cancer and Normal Stem Cells. Authors / Editors: J. A. Marchal, H. Boulaiz, M. Perán, J. C. Prados, J. Campos, F. J. González, F. Rodríguez-Serrano, C. Melguizo, C. Vélez, E. Carrillo, F. Hita, R. Ortiz, A. Martínez-Amat, O. Caba, C. Ventura, A. Aránega. 2008. Binding: e-Book. Nova Science Publishers, Inc., 400 Oser Avenue, Suite 1600, Hauppauge, NY 11788, EE UU. ISBN 978-1-60741-391-2.

    9.- “2D-QSAR: The Mathematics behind the Drug Design Methodology, vol. 1, Capítulo 4” en "New Developments in Medicinal Chemistry". (Editores: Carlton A. Taft & Carlos H. T. P. Silva). Ana Conejo-García, Miguel A. Gallo, Antonio Espinosa, Joaquín María Campos. 2010, 79-94. Bentham eBooks. eISBN: 978-1-60805-127-4, 2010.

    10.- “Rapid Development of Chiral Drugs in the Pharmaceutical Industry, vol. 1, Capítulo 5” en "New Developments in Medicinal Chemistry". (Editores: Carlton A. Taft & Carlos H. T. P. Silva). María del Carmen Núñez, Miguel Ángel Gallo, Antonio Espinosa, Joaquín María Campos. 2010, 95-113. Bentham eBooks. eISBN: 978-1-60805-127-4.

    11.- "Benzo-fused seven- and six-membered derivatives linked to pyrimidines or purines induce apoptosis of human metastatic breast cancer MCF-7 cells in vitro" en “Breast Cancer- Current and Alternative Therapeutic Modalities". (Editors: Esra Gunduz and Mehmet Gunduz). Joaquín M. Campos, María C. Núñez, Ana Conejo-García, Olga Cruz-López. 2011, 115-132. InTech. Open Access Publisher, Capítulo 6. ISBN: 978-953-307-776-5.

    12.- La investigación como herramienta potenciadora de la docencia universitaria en "Excelencia Docente II, Reconocimientos en Educación Superior". Joaquín María Campos Rosa. 2011, 47-53. Editor "Universidad de Granada", Dirección Colección: Isidro López-Aparicio. ISBN: 978-84-338-5210-6.

    13.- "Apoptosis as a Therapeutic Target in Cancer and Cancer Stem Cells: Novel Strategies and Futures Perspectives" en “Apoptosis and Medicine". (Editor: Tobias M. Ntuli). María A. García, Macarena Perán, Esther Carrasco, Alberto Ramírez, Gema Jiménez, Elena López-Ruiz, Manuel Picón, Joaquín Campos, Juan Antonio Marchal. Capítulo 5. 2012, 111-154. InTech. Open Access Publisher. ISBN: 980-953-307-491-2.

    14.- "Acyclic 5-Fluorouracil O,N-Acetals: Antiproliferative Activities, Cell-Cycle Regulation, Apoptosis and Cellular Differentiation" en “Fluorouracil: Synthesis, Health Effects and Role in Chemotherapy". pp 1-38; (Editors: Alberto C. Dário and Sebastiao E. Britto Dobreiro). Nawal Mahfoudh, Angélica Luque, Cayetana Ferrer, Esther Hernández, Joaquín M. Campos. 2012, 1-38. NOVA Publishers. Binding: Hardcover. Series: Pharmacology- Research, Safety, Testing and Regulation Cancer Etiology, Diagnosis and Treatments. ISBN: 978-1-62081-970-8.

    15.- Química Farmacéutica I. Joaquín M. Campos Rosa y Encarnación Camacho Quesada. 2013. Editorial Universidad de Granada. Depósito Legal: GR./145-2013. ISBN: 978-84-338-5491-9 (vol. I). ISBN: 978-84-338-5490-2 (obra completa).

    16.- Química Farmacéutica II. Joaquín M. Campos Rosa y Encarnación Camacho Quesada. 2013. Editorial Universidad de Granada. Depósito Legal: GR./145-2013. ISBN: 978-84-338-5491-9 (vol. II). ISBN: 978-84-338-5490-2 (obra completa).

    17.- “Enantiomerically Pure Substituted Benzo-Fused Heterocycles: A New Class of Anti-Breast Cancer Agents” en “Breast Cancer", (Editor: Mehmet Gunduz). Joaquín M. Campos, M. Eugenia García-Rubiño, Nawal Mahfoudh, César Lozano-López. 2015. InTech d.o.o, Janeza Trdine 9,51000 Rijeka, Croatia. ISBN 978-953-51-4177-8.

    18.- “Symmetrical Pyridinium-Phanes and –Cyclophanes: Promising Heterocyclic Scaffolds for the Development of Anti-Leishmanial Agents en “Scope of Novel Heterocycles from Organic and Pharmaceutical Perspective, (Editor: Dr. Ravi Varala). Joaquín M. Campos, Verónica Gómez-Pérez, Santiago Castanys, Francisco Gamarro. 2016. InTech d.o.o, Janeza Trdine 9,51000 Rijeka, Croatia. ISBN 978-953-51-4632-2.

    19.- “Pharmaceutical Chemistry. Volume 1: Drug design and action”. Joaquín María Campos Rosa, María Encarnación Camacho Quesada. 2017. De Gruiter, Berlín (Alemania). ISBN 978-3-11-052836-7, e-ISBN 978-3-11-052848-0.

    20.- Pharmaceutical Chemistry. Volume 2: Drugs and their biological targets. Joaquín María Campos Rosa, María Encarnación Camacho Quesada. 2017. De Gruiter, Berlín (Alemania). ISBN 978-3-11-05285107-011. e-ISBN (PDF) 978-3-11-052852-7. e-ISBN (EPUB) 978-3-11-052860-2.