N Concordance 1 Only four of these patients had grossly multicentric disease noted clinically be 2 ns in patients with gross multifocal or multicentric disease indicates that a su 3 l management in extensive metastatic or multicentric disease is less rigidly def 4 ignancy in the breast, while pathologic multicentric disease is defined as two o 5 le on recurrence rates in patients with multicentric disease treated with conser 6 le effective at eradicating microscopic multicentric disease, does not prevent t 7 ogically, breast cancer is frequently a multicentric disease. However, clinical