N Concordance 1 ministered with the uroprotectant agent mesna. Ifosfamide also requires hepatic 2 cognized the efficacy of ifosfamide and mesna in the treatment of patients with 3 xicity following intrathecal MTX and/or mesna before and after cyclophosphamide 4 his complication. Upon renal excretion, mesna (mercaptoethane sulfonate) is hydr 5 latin; the combinations of ifosfamide, mesna, and etoposide [6,7] and of cispla 6 consisting of alternating courses of mesna, ifosfamide, mitoxantrone, and et 7 onship between and urinary excretion of mesna and dimesna also was examined by c 8 t difference in the pharmacokinetics of mesna between patients who developed hem 9 osfamide with the urothelial protectant mesna induced a 20 percent response rate 10 2 oral cyclophosphamide), allergies to mesna (2). None of the women at risk had