N Concordance 1 estern blot, lymphoproliferation assay, cytotoxic T-cell lysis, CD8-depleted co- 2 er strains of mice and develop a weaker cytotoxic T-cell response upon challenge 3 ting Epstein-Barr virus (EBV)-specific cytotoxic T-cell lines from patients wit 4 BACKGROUND: Recipient antidonor cytotoxic T-cell activity has been assoc 5 e activation. The vigorous polyspecific cytotoxic T-cell (CTL) response directed 6 Gene transfer was applied to the murine cytotoxic T-cell line cl96. All recombin 7 also capable of inducing a strong CD8+ cytotoxic T-cell (CTL) response in immun 8 tricted peptide representing a dominant cytotoxic T-cell epitope, in patients w 9 o patients. In both cases, several CD4+ cytotoxic T-cell (CTL) clones were estab 10 tural-killer-cell-stimulatory factor or cytotoxic-T-cell-maturation factor. Thes 11 r burden. In this model, tumor-specific cytotoxic T-cells (CTL) could also be in 12 of DCs. Also, IL-12 blocks apoptosis of cytotoxic T-cells and DCs. Other potent 13 es of splenic B and T lymphocytes or of cytotoxic T-cells. Neither did they chan