Dr. Juan Manuel Cuerva
Carvajal
Juan M. Cuerva nació en Granada en
1969. Se licenció en Ciencias Químicas por la
Universidad de Granada (1992) y obtuvo el
titulo de Doctor en la Universidad Autónoma de
Madrid (1997) dirigido por el Prof. A.
Echavarren,
becado por la Comunidad Autónoma
de Madrid. En 1997 fue contratado como
Profesor Asociado en el Departamento de
Química Orgánica de la Universidad Autónoma de
Madrid. En 1998 obtuvo una plaza de
Profesor Ayudante en la Universidad de Granada,
y finalmente promocionó a Profesor Titular en
Química Orgánica en 2003.
Desde Enero de 2010 dirige el grupo de
investigación FQM-013 "Química Organometálica
y Electrónica Molecular". El Prof. Cuerva ha
sido científico invitado en la Universidad de Bonn.
Lista de Publicaciones:
-Two sesquilignans from the woods of Abies
marocana. Phytochemistry 1996,
41, 609.
-Palladium-catalyzed reductive coupling of
acid chlorides with b-stannyl enones. J. Org. Chem.
1994, 59, 4179.
-Design and synthetic applications of new
heteromethallacycles. Bull. Soc.
Chim. Belg. 1994, 103, 549.
-A concise synthesis of Monomorine I by way
of palladium-catalyzed reductive coupling.
Tetrahedron Lett. 1994, 35, 7435.
-Michael reaction of stabilized carbon
nucleophiles catalized by RuH2(PPh3)4.
J. Am. Chem. Soc. 1996,
118, 8553.
-Cationic intermediates in the
intramolecular insertion of alkenes into (h3-allyl)palladium(II)
complexes. Angew. Chem., Int. Ed.
Engl. 1996, 36, 767.
-Synthesis of heterocyclic quinones by aza-Diels-Alder
reaction of 4-stannyl-1-azadiene. Synlett
1997, 173.
-Synthesis of 10-epi-elemol by a highly
stereoselective intramolecular palladium-catalyzed
coupling of an allylstannane with an allyl
acetate. J. Org. Chem. 1997, 62,
7540.
-Direct synthesis of N-aryl quinone imine
acetals and quinol imines from acetals. Angew. Chem., Int. Ed. Engl.
1999, 38, 1449.
-New synthesis of pyridoacridines based on
an intramolecular aza-Diels-Alder reaction
followed by an unprecedented rearrangement. Chem. Commun.
1999, 1721.
-Preparation of bioactive podolactones via
a new Pd-catalysed bislactonizsation reaction.
Synthesis of oidiolactone C. Tetrahedron
Lett. 2000, 41, 5203.
-Synthetic applications of the thermal
rearrangement of azonides: First
enantiospecific synthesis of marine metabolite
Luffarin W. Synlett 2000, 1269.
-Approach to the synthesis of antitumor
quassinoids from labdane diterpenes: an
efficient synthesis of a picrasane-related
intermediate. Org. Lett. 2001,
3, 647.
-A New strategy for the synthesis of cyclic
terpenoids based on the radical opening of
acyclic epoxypolyenes. J. Org. Chem.
2001, 66, 4074.
-Intramolecular Michael-type addition of
azadienes to 1,4-naphtoquinones instead of aza-Diels-Alder
cycloaddition: a synthesis of ascididemine. J. Chem. Soc., Perkin Trans. 1
2002,
1360.
-Effects of solvent and water in Ti(III)-mediated
radical cyclization of epoxygermacrolidas.
Straightforward synthesis and absolute
stereochemistry of (+)-3ª-hydroxyreynosin and
related eudesmanolides. J. Org. Chem.
2002, 67, 2566.
-Intramolecular Coupling of allyl
carboxylates with allyl stannanes and allyl
silanes: a new type of reductive elimination
reaction?. Chem. Eur.
J. 2002, 8, 3620.
-First Synthesis of Achilleol A using
Titanium(III) chemistry. Tetrahedron
Lett. 2002, 43, 2793.
-Titanium-catalysed, selective reduction of
ketones in aqueous media. A safe, mild,
inexpensive procedure for the synthesis of
secundary alcohols via radical chemistry. Tetrahedron
Lett.
2003, 44, 1079.
-Unified synthesis of eudesmanolides
combining biomimetic strategics with
homogeneous catalysis and free-radical
chemistry. Org. Lett. 2003, 5, 1935.
-Titanocene Catalyzed cascade cyclization
of epoxypolyprenes: Straightforward síntesis
of terpenoids via free-radical chemistry. Chem. Eur. J.
2004, 10, 1778.
-Palladium mediated C-H activation in the
field of terpenoids: synthesis of rostratone.
Tetrahedron Lett. 2004, 45, 4293.
-General approach to polycyclic
meroterpenoids based on Stille couplings and
titanocene catalysis J. Org. Chem.
2004, 69, 5803.
-Unprecedented Barbier-type reactions
catalysed by titanocene(III). Chem.
Commun. 2004, 2628.
-Enantiospecific strategy towards oxygen-bridged
terpenoids. unprecedented tandem reaction
combining transannular cyclization and ring-contraction
processes. Angew. Chem. Int. Ed. 2005,
44, 322.
-Total synthesis of 3-hydroxy-drimanes
mediated by titanocene(III). Evaluation of
their antifeedant activity. Eur. J. Org. Chem.
2005, 712.
-Exploiting PdII and TiIII Chemistry to
Obtain γ-Dioxygenated Terpenoids: Synthesis of
Rostratone and Novel Approaches to Aphidicolin
and Pyripyropene A. J. Org. Chem. 2005,
70, 8265.
-Bassialone: an antimicrobial precursor of
cephalosporolides E and F from the
entomoparasitic fungus Beuveria Bassiana. Org.
Biomol. Chem. 2005, 3, 1772.
- Composition of the essential oils of Cistus
ladaniferus and c. monspeliensis from morocco.
J. Ess. Oil 2005, 17,
553.
-7-endo Radical Cyclizations Catalyzed by
Titanocene(III). Straightforward Synthesis of
Terpenoids with Seven-Membered Carbocycles.
J. Am. Chem. Soc. 2005, 17,
14911.
-Aromatic carbonyl compound reduction and
pinacol coupling processes mediated by
titanocene(III)/Zn in water. Synthesis
2005, 2619.
-The growing impact of titanocene(III)-mediated
radical epoxide opening on the synthesis of
natural products. Mini-Reviews in Organic
Chemistry 2006, 3, 23.
-An improved synthesis of Kagan's menthyl
substituted titanocene and zirconocene
dichloride, comparison of their crystal
structures, and preliminary catalyst
evaluation. J. Organomet. Chem. 2006,
691, 2327.
-Composition of the essential oil from the
seeds of Abies marocana. J. Ess. Oil 2006,
18, 260.
-Cp2TiCl in natural product
synthesis. Top. Curr. Chem. 2006,
264, 63.
-Water: the ideal hydrogen-atom source in
free-radical chemistry mediated by TiIII and
other single-electron-transfer metals?.
Angew. Chem. Int. Ed. 2006, 45,
5522.
-Granadaene: proposed structure of the group B
streptococcus polyenic pigment. Appl.
Environ. Microbiol. 2006, 72,
6367.
-Transition-metal-catalyzed allylic
substitution and titanocene-catalyzed
epoxypolyene cyclization as a powerful tool
for the preparation of terpenoids. Eur. J.
Org. Chem. 2006, 4115.
-Stereocontrolled Coupling between Aldehydes
and Conjugated Alkenals Mediated by TiIII/H2O.
Org. Lett. 2006, 8,
5433-5436.
-Unprecedented Hydrogen Transfer from Water
to Alkenes and Alkynes Mediated by Ti(III) and
Late Transition Metals. Org. Lett.
2007, 9, 2195-2198.
-Sodium Tetramethoxyborate: An Efficient
Catalyst for Michael Additions of Stabilized
Carbon Nucleophiles A. G. Campaña, N.
Fuentes, E. Gómez-Bengoa, C. Mateo, J. E.
Oltra, A. M. Echavarren, J. M. Cuerva J.
Org. Chem. 2007, 72,
8127-8130.
-Ti-Catalyzed
Reformatsky-Type Coupling between
 -Halo
Ketones and Aldehydes
R. E. Estévez, M.
Paradas, A. Millán, T. Jiménez, R. Robles, J.
M. Cuerva, J. E. Oltra J.
Org. Chem. 2008, 73,
1616-1619.
-"Titanium-Catalyzed Enantioselective
Synthesis of a-Ambrinol"
J. Justicia, A. G. Campaña, B. Bazdi, R.
Robles, J. M. Cuerva, J. E. Oltra Adv. Synth.
Catal. 2008, 350, 571-576.
-"Divergent Titanium-mediated
Allylations with Modulation by Nickel or
Palladium" A. G. Campaña, B. Bazdi, N.
Fuentes, R. Robles, J. M. Cuerva, J. E. Oltra,
S. Porcel, A. M. Echavarren Angew. Chem.
Int. Ed. 2008, 47,
7515-7519.
-"Ti-Catalyzed Barbier-type
Allylations and Related Reactions" R. E.
Estévez, J. Justicia, B. Bazdi, N. Fuentes, M.
Paradas, D. Choquesillo-Lazarte, J. M.
García-Ruiz, R. Robles, A. Gansäuer, J. M. Cuerva, J. E.
Oltra Chem.,
Eur. J. 2009,
15,
2774-2791.
-"Unexpected TiIII/Mn-Promoted
Pinacol Coupling of Ketones" M.
Paradas, A. G. Campaña, R. E. Estévez, L.
Älvarez de Cienfuegos, T. Jiménez, R. Robles, J. M. Cuerva, J. E.
Oltra J. Org.
Chem. 2009,
74,
3616-3619.
-"Efficient Propargylation of
Aldehydes and Ketones Catalyzed by
Titanocene(III)" J. Justicia, I. Sancho-Sanz,
E. Álvarez-Manzaneda, J. E. Oltra, J. M.
Cuerva Adv. Synth.
Catal. 2009,
351,
2295-2300.
-"Radical Reduction of
Epoxides Using a Titanocene(III)/Water System:
Synthesis of β-Deuterated Alcohols and Their
Use as Internal Standards in Food Analysis" T.
Jiménez, A. G. Campaña, B. Bazdi, M. Paradas,
D. Arráez-Román, A. Segura-Carretero, A-
Fernández-Gutiérrez, J. E. Oltra, R. Robles,
J. Justicia, J. M. Cuerva Eur. J. Org. Chem.
2010, 4288–4295.
-"Unprecedented H-Atom
Transfer from Water to Ketyl Radicals mediated
by Cp2TiCl" M. Paradas, A. G.
Campaña, M. L. Marcos, J. Justicia, A. Haidour,
R. Robles, D. J. Cárdenas, J. E. Oltra, J. M.
Cuerva Dalton Trans.,
2010,
39, 8796-8800.
-"Understanding
the Exceptional Hydrogen-Atom Donor
Characteristics of Water in TiIII-Mediated
Free-Radical Chemistry"
M. Paradas, A. G. Campaña, T. Jiménez, R.
Robles, J. E. Oltra, E. Buñuel, J. Justicia,
D. J. Cárdenas, J. M.
Cuerva J. Am. Chem. Soc.
2010, 132,
12748-12756.
-"Mn(0)-Mediated
Chemoselective Reduction of Aldehydes.
Application to the Synthesis of
a-Deuterioalcohols"
T. Jiménez, E. Barea, J. E. Oltra, J. M.
Cuerva, J. Justicia J. Org. Chem.
2010, 75, 7022-7025.
-"on/off
Electrochemical Switches
Based on
Quinone-Bisketals"
N. Fuentes, L. Álvarez de Cienfuegos,
A. Parra, D. Choquesillo-Lazarte, J. M.
García-Ruiz, M. L. Marcos, E. Buñuel, M.
Ribagorda, M. C. Carreño, D. J. Cárdenas, J.
M. Cuerva Chem. Commun. 2011,
47, 1586-1588. Este artículo ha recibido una
mención especial en la revista Chemicals&Engineering
News (ver
aqui).
-"Titanium/Palladium-Mediated
Regioselective
Propargylation of Ketones
Using Propargylic
Carbontates as
Pronucleophiles"
A. Millán, L. Álvarez
de Cienfuegos, A.
Martín-Lasanta, A. G.
Campaña, J. M. Cuerva
Adv. Synth.
Catal. 2011,
353,
73-78.
-"Ti/Pd
Bimetallic Systems for the Efficient
Allylation of Carbonyl Compounds and
Homocoupling reactions"
A. Millán, A. G.
Campaña, B. Bazdi, D. Miguel, L.
Álvarez
de Cienfuegos, A. M.
Echavarren, J. M. Cuerva
Chem.,
Eur. J. 2011,
17,
DOI: 10.1002/chem.201003315.
-"Titanocene(III)-Promoted
Barbier-type Crotilation of Carbonyl Compounds"
I. Sancho-Sanz, D. Miguel, A. Millán, R. E.
Estévez, J. L. Oller-López, E. Álvarez-Manzaneda,
R. Robles, J. M. Cuerva, J. Justicia J. Org. Chem.
2011, 76, 732-735.
-"Conductance
and Application of
Organic
Molecule Pairs as
Nanofuses" S.
Rodríguez-Bolívar, F.
M. Gómez-Camposa, L.
Álvarez de Cienfuegos,
N. Fuentes, D.
J. Cárdenas, E. Buñuel,
J. E. Carcellera, A.
Parra, J. M. Cuerva
Phys. Rev. B
2011, 83,
125424/1-125424/11.
-"Mild Method for the
Selective Esterification of Carboxylic Acids
Based on the Garegg-Samuelsson Reaction"
S. Morcillo, L. Álvarez de Cienfuegos, A. J.
Mota, J. Justicia, R. Robles J. Org. Chem.
2011, 76, 2277-2281.
-"Bioinspired
Terpene
Synthesis: a Radical
Approach"
J. Justicia, L. Álvarez de Cienfuegos, A. G.
Campaña, D. Miguel, V. Jakoby, A. Gänsauer, J.
M. Cuerva Chem. Soc. Rev. 2011,
40, 3525-3537.
-"Reduction Reactions in water,
supercritical CO2 and ionic liquids as green
solvents" L. Álvarez de Cienfuegos, R.
Robles, D. Miguel, J. Justicia, J. M. Cuerva
Chem. Sus. Chem. 2011,
ASAP.
-"Water-based Hydrogen-Atom
Wires as Mediators in Long-Range Proton-Coupled
Electron Transfer in Enzymes: a New
Twist on Water Reactivity" D. J.
Cárdenas, J. M. Cuerva, M. Alías, E.
Buñuel, A. G. Campaña Chem. Eur.
J. 2011,
17, 8318–8323.
-"Water-based Hydrogen-Atom
Wires as Mediators in Long-Range Proton-Coupled
Electron Transfer in Enzymes: a New
Twist on Water Reactivity" N.
Fuentes, A.
Martín-Lasanta, L.
Álvarez de Cienfuegos, M.
Ribagorda, A.
Parra, J. M. Cuerva
Nanoscale 2011,
aceptada.
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