Mecanismos de detoxificación hepática frente a compuestos organofosforados: papel de las organofosforo-hidrolasas (paraoxonasa)

 

Gil F , Pla A, Gonzalvo MC, Hernández AF, Villanueva E. Rat liver paraoxonase: subcellular distribution and characterization. Chemico-Biological Interactions 1993; 87: 149-154 [Medline]

Gil F , Pla A, Gonzalvo MC, Hernández AF , Villanueva E. Partial purification of paraoxonase from rat liver. Chemico-Biological Interactions 1993; 87: 69-75 [Medline]

Gil F , Gonzalvo MC, Hernández AF , Villanueva E, Pla A. Differences in the kinetic properties, effect of calcium and sensitivity to inhibitors of paraoxon hydrolase activity in rat plasma and microsomal fraction from rat liver.
Biochemical Pharmacology 1994; 48: 1559-1568 [Medline]

Rodrigo L, Gil F , Hernández AF, Marina A, Vázquez J, Pla A. Purification and characterization of paraoxon hydrolase from rat liver. Biochemical Journal 1997; 321: 595-601 [Medline]

Hernández AF, Gonzalvo MC, Gil F , Villanueva E, Pla A. Divergent effects of classical inducers on rat plasma and liver microsomal paraoxonase and arylesterase. Environmental Toxicology and Pharmacology 1997; 3: 83-86 [Medline]

Gonzalvo MC, Gil F , Hernández AF , Villanueva E, Pla A. Inhibition of paraoxonase activity in human liver microsomes by exposure to EDTA, metals and mercurials. Chemico-Biological Interactions 1997; 105: 169-179 [Medline]

Gonzalvo MC, Gil F , Hernández AF , Rodrigo L, Villanueva E, Pla A.
Human liver paraoxonase (PON1): Subcellular distribution and characterization. Journal of Biochemical and Molecular Toxicology 1998; 12: 61-69 [Medline]

Rodrigo L, Gil F , Hernández AF, Pla A. Identification of two rat liver proteins with paraoxonase activity: Biochemical evidence for the identity of paraoxonase and arylesterase. Chemico-Biological Interactions 1999; 119-120: 263-275 [Medline]

Rodrigo L, Hernández AF, López Caballero JJ, Gil F , Pla A. Immunohistochemical evidence for the expression and induction of paraoxonase in rat liver, kidney, lung and brain tissue. Implications for its physiological role. Chemico-Biological Interactions 2001; 137: 123-137 [Medline]

Rodrigo L, Gil F , Hernández AF , López O, Pla A. Identification of paraoxonase 3 in rat liver microsomes. Purification and bio chemical properties. Biochemical Journal 2003; 376: 261-68 [Medline]

  A Pla, Rodrigo L, Hernández AF, Gil F , López O. Effect of metal ions and calcium on purified PON1 and PON3 from rat liver. Chemico-Biological Interactions 2007; 167(1):63-70 [Medline]