New possibility for obtaining of 7-[2-(ethylsulfonyl)-ethy]-1,3-dimethylxanthine and 1-[2-(ethylilsulfonyl)-ethyl]-3,7-dimethylxanthine and kinetics assessment of the reaction
Peikov, P. y Zlatkov, Al.
Department of Pharmaceutical Chemistry. Faculty of Pharmacy. 2 Dunav Street. 1000 Sofia. Bulgaria
Ars Pharm.36;(2);215-21, (1995)
Key words: 1,3-dimethylxanthine, 3,7-dimethylxanthine, Acid catalyst, KineticsAbstract
A new possibility of obtaining of 7-[2-(ethylsulfonyl)-ethyl]-1,3-dimethylxanthine and 1-[2-(ethylsulfonyl)-ethyl]-3,7-dimethylxanthine derivatives with potential biologic activity is presented. With aim to obtain the title compounds in optimal yield and purity, the influence of the molar ratio of the reactants, reaction medium and role of acid catalyst on the progress of the reaction was investigated. The optimal reaction time was determined and the dependence of yield and reaction time was established.
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